1HDY
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1HDZ
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1HDX
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1O05
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1ZCU
| apo form of the 162S mutant of glycogenin | Descriptor: | Glycogenin-1 | Authors: | Hurley, T.D, Stout, S.L, Miner, E, Zhou, J, Roach, P.J. | Deposit date: | 2005-04-13 | Release date: | 2005-04-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Requirements for catalysis in mammalian glycogenin. J.Biol.Chem., 280, 2005
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1ZCV
| apo form of a mutant of glycogenin in which Asp159 is replaced by Asn | Descriptor: | Glycogenin-1, SULFATE ION | Authors: | Hurley, T.D, Stout, S.L, Miner, E, Zhou, J, Roach, P.J. | Deposit date: | 2005-04-13 | Release date: | 2005-04-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Requirements for catalysis in mammalian glycogenin. J.Biol.Chem., 280, 2005
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1ZCT
| structure of glycogenin truncated at residue 270 in a complex with UDP | Descriptor: | Glycogenin-1, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE | Authors: | Hurley, T.D, Stout, S.L, Miner, E, Zhou, J, Roach, P.J. | Deposit date: | 2005-04-13 | Release date: | 2005-04-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Requirements for catalysis in mammalian glycogenin. J.Biol.Chem., 280, 2005
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1ZDF
| Ser162 mutant of glycogenin complexed with UDP-glucose and manganese | Descriptor: | Glycogenin-1, MANGANESE (II) ION, SULFATE ION, ... | Authors: | Hurley, T.D, Stout, S.L, Miner, E, Zhou, J, Roach, P.J. | Deposit date: | 2005-04-14 | Release date: | 2005-04-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Requirements for catalysis in mammalian glycogenin. J.Biol.Chem., 280, 2005
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1ZCY
| apo form of a mutant of glycogenin in which Asp159 is replaced by Ser | Descriptor: | Glycogenin-1, SULFATE ION | Authors: | Hurley, T.D, Stout, S.L, Miner, E, Zhou, J, Roach, P.J. | Deposit date: | 2005-04-13 | Release date: | 2005-04-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Requirements for catalysis in mammalian glycogenin. J.Biol.Chem., 280, 2005
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1ZDG
| Ser159 mutant of glycogenin complexed with UDP-glucose and manganese | Descriptor: | Glycogenin-1, MANGANESE (II) ION, SULFATE ION, ... | Authors: | Hurley, T.D, Stout, S.L, Miner, E, Zhou, J, Roach, P.J. | Deposit date: | 2005-04-14 | Release date: | 2005-04-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Requirements for catalysis in mammalian glycogenin. J.Biol.Chem., 280, 2005
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3HUD
| THE STRUCTURE OF HUMAN BETA 1 BETA 1 ALCOHOL DEHYDROGENASE: CATALYTIC EFFECTS OF NON-ACTIVE-SITE SUBSTITUTIONS | Descriptor: | ALCOHOL DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION | Authors: | Hurley, T.D, Bosron, W.F, Hamilton, J.A, Amzel, L.M. | Deposit date: | 1993-01-04 | Release date: | 1994-01-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions. Proc.Natl.Acad.Sci.USA, 88, 1991
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2O8G
| Rat pp1c gamma complexed with mouse inhibitor-2 | Descriptor: | MANGANESE (II) ION, Protein phosphatase inhibitor 2, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | Authors: | Hurley, T.D. | Deposit date: | 2006-12-12 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J.Biol.Chem., 282, 2007
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2O8A
| rat PP1cgamma complexed with mouse inhibitor-2 | Descriptor: | Protein phosphatase inhibitor 2, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | Authors: | Hurley, T.D. | Deposit date: | 2006-12-12 | Release date: | 2007-07-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J.Biol.Chem., 282, 2007
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4V6B
| Crystal structure of human ferritin Phe167SerfsX26 mutant. | Descriptor: | CALCIUM ION, Ferritin | Authors: | Hurley, T.D, Vidal, R. | Deposit date: | 2009-06-19 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration J.Biol.Chem., 285, 2010
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1DEH
| CRYSTALLIZATION OF HUMAN BETA1 ALCOHOL DEHYDROGENASE (15 MG/ML) IN 50 MM SODIUM PHOSPHATE (PH 7.5), 2.0 MM NAD+ AND 1 MM 4-IODOPYRAZOLE AT 25 OC, 13% (W/V) PEG 8000 | Descriptor: | 4-IODOPYRAZOLE, CHLORIDE ION, HUMAN BETA1 ALCOHOL DEHYDROGENASE, ... | Authors: | Hurley, T.D, Davis, G.J. | Deposit date: | 1995-10-14 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | X-ray structure of human beta3beta3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding. J.Biol.Chem., 271, 1996
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4Y3U
| The structure of phospholamban bound to the calcium pump SERCA1a | Descriptor: | Cardiac phospholamban, POTASSIUM ION, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Authors: | Hurley, T.D. | Deposit date: | 2015-02-10 | Release date: | 2015-02-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum. J. Biol. Chem., 288, 2013
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8T0N
| Structure of Compound 4 bound to human ALDH1A1 | Descriptor: | 2-methoxy-6-{[(1-propyl-1H-benzimidazol-2-yl)amino]methyl}phenol, Aldehyde dehydrogenase 1A1, CHLORIDE ION, ... | Authors: | Hurley, T.D. | Deposit date: | 2023-06-01 | Release date: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes. Chem.Biol.Interact., 391, 2024
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8T0T
| Structure of Compound 4 bound to human ALDH1A1 | Descriptor: | 1-(4-{6-fluoro-3-[4-(methanesulfonyl)piperazine-1-carbonyl]quinolin-4-yl}phenyl)cyclopropane-1-carbonitrile, Aldehyde dehydrogenase 1A1, CHLORIDE ION, ... | Authors: | Hurley, T.D. | Deposit date: | 2023-06-01 | Release date: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes. Chem.Biol.Interact., 391, 2024
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1HTB
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5TEI
| Structure of human ALDH1A1 with inhibitor CM039 | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 6-{[(3-fluorophenyl)methyl]sulfanyl}-5-(2-methylphenyl)-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, CHLORIDE ION, ... | Authors: | Morgan, C.A, Hurley, T.D. | Deposit date: | 2016-09-21 | Release date: | 2017-09-27 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of human ALDH1A1 with inhibitor CM039 To Be Published
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5UW4
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7UM9
| Human ALDH1A1 with bound compound CM38 | Descriptor: | (4-methylfuro[3,2-c]quinolin-2-yl)(piperidin-1-yl)methanone, CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Hurley, T.D. | Deposit date: | 2022-04-06 | Release date: | 2023-04-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer. Cancers (Basel), 14, 2022
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2HZY
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4KYT
| The structure of superinhibitory phospholamban bound to the calcium pump SERCA1a | Descriptor: | Cardiac phospholamban, POTASSIUM ION, SERCA1a, ... | Authors: | Hurley, T.D, Akin, B.L, Jones, L.R. | Deposit date: | 2013-05-29 | Release date: | 2013-09-04 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.833 Å) | Cite: | The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum. J.Biol.Chem., 288, 2013
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4KWF
| Crystal Structure Analysis of ALDH2+ALDiB33 | Descriptor: | 1,2-ETHANEDIOL, 1-benzyl-1H-indole-2,3-dione, Aldehyde dehydrogenase, ... | Authors: | Hurley, T.D, Kimble-Hill, A.C. | Deposit date: | 2013-05-24 | Release date: | 2014-04-09 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. J.Med.Chem., 57, 2014
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