2HZY

Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate

Summary for 2HZY

Entry DOI	10.2210/pdb2hzy/pdb
Related	1HYO 1QCN 1QCO 1QQJ
Descriptor	Fumarylacetoacetase, SODIUM ION, MANGANESE (II) ION, ... (7 entities in total)
Functional Keywords	transition-state mimicking complex, hydrolase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	93852.45
Authors	Hurley, T.D.,Timm, D.E. (deposition date: 2006-08-09, release date: 2006-08-22, Last modification date: 2023-08-30)
Primary citation	Bateman, R.L.,Ashworth, J.,Witte, J.F.,Baker, L.J.,Bhanumoorthy, P.,Timm, D.E.,Hurley, T.D.,Grompe, M.,McClard, R.W. Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics. Biochem.J., 402:251-260, 2007 Cited by PubMed: 17064256 DOI: 10.1042/BJ20060961 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation