1ORK
| TET REPRESSOR, CLASS D IN COMPLEX WITH 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEMETHYL-6-DEOXY-TETRACYCLINE | Descriptor: | 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEOXY-6-DEMETHYL-TETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR | Authors: | Orth, P, Schnappinger, D, Sum, P.-E, Ellestad, G.A, Hillen, W, Saenger, W, Hinrichs, W. | Deposit date: | 1998-05-21 | Release date: | 1999-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline. J.Mol.Biol., 285, 1999
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1A6I
| TET REPRESSOR, CLASS D VARIANT | Descriptor: | TETRACYCLINE REPRESSOR PROTEIN CLASS D | Authors: | Orth, P, Cordes, F, Schnappinger, D, Hillen, W, Saenger, W, Hinrichs, W. | Deposit date: | 1998-02-25 | Release date: | 1999-03-02 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Conformational changes of the Tet repressor induced by tetracycline trapping. J.Mol.Biol., 279, 1998
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1QPI
| CRYSTAL STRUCTURE OF TETRACYCLINE REPRESSOR/OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*CP*CP*TP*AP*TP*CP*AP*AP*TP*GP*AP*TP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*TP*CP*AP*TP*TP*GP*AP*TP*AP*GP*G)-3'), IMIDAZOLE, ... | Authors: | Orth, P, Schnappinger, D, Hillen, W, Saenger, W, Hinrichs, W. | Deposit date: | 1999-05-25 | Release date: | 2000-02-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system. Nat.Struct.Biol., 7, 2000
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1ZVV
| Crystal structure of a ccpa-crh-dna complex | Descriptor: | DNA recognition strand CRE, Glucose-resistance amylase regulator, HPr-like protein crh, ... | Authors: | Schumacher, M.A, Brennan, R.G, Hillen, W, Seidel, G. | Deposit date: | 2005-06-02 | Release date: | 2006-02-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. J.Biol.Chem., 281, 2006
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3FK7
| Crystal structure of TetR triple mutant (H64K, S135L, S138I) in complex with 4-ddma-atc | Descriptor: | (4aS,12aS)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide, MAGNESIUM ION, Tetracycline repressor protein class B from transposon Tn10, ... | Authors: | Klieber, M.A, Scholz, O, Lochner, S, Gmeiner, P, Hillen, W, Muller, Y.A. | Deposit date: | 2008-12-16 | Release date: | 2009-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair. Febs J., 276, 2009
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3FK6
| Crystal structure of TetR triple mutant (H64K, S135L, S138I) | Descriptor: | Tetracycline repressor protein class B from transposon Tn10, Tetracycline repressor protein class D | Authors: | Klieber, M.A, Scholz, O, Lochner, S, Gmeiner, P, Hillen, W, Muller, Y.A. | Deposit date: | 2008-12-16 | Release date: | 2009-10-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair. Febs J., 276, 2009
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3OQN
| Structure of ccpa-hpr-ser46-p-gntr-down cre | Descriptor: | 5'-D(*AP*TP*GP*GP*TP*AP*CP*CP*GP*CP*TP*TP*TP*CP*AP*A)-3', 5'-D(*TP*TP*GP*AP*AP*AP*GP*CP*GP*GP*TP*AP*CP*CP*AP*T)-3', Catabolite control protein A, ... | Authors: | Schumacher, M.A, Sprehe, M, Bartholomae, M, Hillen, W, Brennan, R.G. | Deposit date: | 2010-09-03 | Release date: | 2010-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. Nucleic Acids Res., 39, 2011
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3OQM
| structure of ccpa-hpr-ser46p-ackA2 complex | Descriptor: | 5'-D(*TP*TP*GP*AP*TP*AP*AP*CP*GP*CP*TP*TP*AP*CP*AP*A)-3', 5'-D(*TP*TP*GP*TP*AP*AP*GP*CP*GP*TP*TP*AP*TP*CP*AP*A)-3', Catabolite control protein A, ... | Authors: | Schumacher, M.A, Sprehe, M, Bartholomae, M, Hillen, W, Brennan, R.G. | Deposit date: | 2010-09-03 | Release date: | 2010-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. Nucleic Acids Res., 39, 2011
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3OQO
| Ccpa-hpr-ser46p-syn cre | Descriptor: | 5'-D(*CP*TP*GP*AP*AP*AP*GP*CP*GP*CP*TP*AP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*TP*AP*GP*CP*GP*CP*TP*TP*TP*CP*AP*G)-3', Catabolite control protein A, ... | Authors: | schumacher, M.A, Sprehe, M, Bartholomae, M, Hillen, W, Brennan, R.G. | Deposit date: | 2010-09-03 | Release date: | 2011-10-26 | Last modified: | 2014-04-09 | Method: | X-RAY DIFFRACTION (2.97 Å) | Cite: | Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. Nucleic Acids Res., 39, 2011
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1SXG
| Structural studies on the apo transcription factor form B. megaterium | Descriptor: | 2-PHENYLAMINO-ETHANESULFONIC ACID, Glucose-resistance amylase regulator | Authors: | Schumacher, M.A, Allen, G.S, Diel, M, Seidel, G, Hillen, W, Brennan, R.G. | Deposit date: | 2004-03-30 | Release date: | 2004-10-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural studies on the apo transcription factor form B. megaterium Cell(Cambridge,Mass.), 118, 2004
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1SXH
| apo structure of B. megaterium transcription regulator | Descriptor: | Glucose-resistance amylase regulator | Authors: | Schumacher, M.A, Allen, G.S, Diel, M, Seidel, G, Hillen, W, Brennan, R.G. | Deposit date: | 2004-03-30 | Release date: | 2004-10-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural studies on the apo transcription factor form B. megaterium Cell(Cambridge,Mass.), 118, 2004
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1SXI
| Structure of apo transcription regulator B. megaterium | Descriptor: | Glucose-resistance amylase regulator, MAGNESIUM ION | Authors: | Schumacher, M.A, Allen, G.S, Diel, M, Seidel, G, Hillen, W, Brennan, R.G. | Deposit date: | 2004-03-30 | Release date: | 2004-10-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural studies on the apo transcription factor form B. megaterium Cell(Cambridge,Mass.), 118, 2004
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2NZU
| Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors G6P and FBP | Descriptor: | 6-O-phosphono-beta-D-glucopyranose, Catabolite control protein, Phosphocarrier protein HPr, ... | Authors: | Schumacher, M.A, Hillen, W, Brennan, R.G. | Deposit date: | 2006-11-25 | Release date: | 2007-05-01 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Mechanism for the Fine-tuning of CcpA Function by The Small Molecule Effectors Glucose 6-Phosphate and Fructose 1,6-Bisphosphate. J.Mol.Biol., 368, 2007
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2NZV
| Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors G6P and FBP | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, Catabolite control protein, Phosphocarrier protein HPr, ... | Authors: | Schumacher, M.A, Hillen, W, Brennan, R.G. | Deposit date: | 2006-11-25 | Release date: | 2007-05-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Mechanism for the Fine-tuning of CcpA Function by The Small Molecule Effectors Glucose 6-Phosphate and Fructose 1,6-Bisphosphate. J.Mol.Biol., 368, 2007
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2NS8
| How an in vitro selected peptide mimics the antibiotic tetracycline to induce TET repressor | Descriptor: | 16 residue peptide Tip (Transcription inducing peptide), Tetracycline repressor protein | Authors: | Luckner, S.R, Klotzsche, M, Berens, C, Hillen, W, Muller, Y.A. | Deposit date: | 2006-11-03 | Release date: | 2007-07-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor J.Mol.Biol., 368, 2007
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2OEN
| Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose-6-phosphate and fructose-1,6-bisphosphate | Descriptor: | Catabolite control protein, Phosphocarrier protein HPr | Authors: | Schumacher, M.A, Seidel, G, Hillen, W, Brennan, R.G. | Deposit date: | 2006-12-30 | Release date: | 2007-05-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Structural Mechanism for the Fine-tuning of CcpA Function by The Small Molecule Effectors Glucose 6-Phosphate and Fructose 1,6-Bisphosphate. J.Mol.Biol., 368, 2007
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2NS7
| How an in vitro selected peptide mimics the antibiotic tetracycline to induce TET repressor | Descriptor: | Tetracycline repressor protein | Authors: | Luckner, S.R, Klotzsche, M, Berens, C, Hillen, W, Muller, Y.A. | Deposit date: | 2006-11-03 | Release date: | 2007-07-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor J.Mol.Biol., 368, 2007
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2VKV
| TetR (BD) variant L17G with reverse phenotype | Descriptor: | 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, ... | Authors: | Resch, M, Striegl, H, Henssler, E.M, Sevvana, M, Egerer-Sieber, C, Schiltz, E, Hillen, W, Muller, Y.A. | Deposit date: | 2008-01-02 | Release date: | 2008-07-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | A Protein Functional Leap: How a Single Mutation Reverses the Function of the Transcription Regulator Tetr. Nucleic Acids Res., 36, 2008
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3ZQF
| Structure of Tetracycline repressor in complex with antiinducer peptide-TAP1 | Descriptor: | ANTI-INDUCER PEPTIDE TAP1, TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, TETRACYCLINE REPRESSOR PROTEIN CLASS D | Authors: | Sevvana, M, Goeke, D, Stoeckle, C, Kaspar, D, Grubmueller, S, Goetz, C, Wimmer, C, Berens, C, Klotzsche, M, Muller, Y.A, Hillen, W. | Deposit date: | 2011-06-09 | Release date: | 2011-12-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | An Exclusive Alpha/Beta Code Directs Allostery in Tetr-Peptide Complexes. J.Mol.Biol., 416, 2012
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3ZQI
| Structure of Tetracycline repressor in complex with inducer peptide- TIP2 | Descriptor: | 1,2-ETHANEDIOL, INDUCER PEPTIDE TIP2, MAGNESIUM ION, ... | Authors: | Sevvana, M, Goeke, D, Stoeckle, C, Kaspar, D, Grubmueller, S, Goetz, C, Wimmer, C, Berens, C, Klotzsche, M, Muller, Y.A, Hillen, W. | Deposit date: | 2011-06-09 | Release date: | 2011-12-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | An Exclusive Alpha/Beta Code Directs Allostery in Tetr-Peptide Complexes. J.Mol.Biol., 416, 2012
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3ZQG
| Structure of Tetracycline repressor in complex with antiinducer peptide-TAP2 | Descriptor: | ANTI-INDUCER PEPTIDE TAP2, TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, TETRACYCLINE REPRESSOR PROTEIN CLASS D | Authors: | Sevvana, M, Goeke, D, Stoeckle, C, Kaspar, D, Grubmueller, S, Goetz, C, Wimmer, C, Berens, C, Klotzsche, M, Muller, Y.A, Hillen, W. | Deposit date: | 2011-06-09 | Release date: | 2011-12-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | An Exclusive Alpha/Beta Code Directs Allostery in Tetr-Peptide Complexes. J.Mol.Biol., 416, 2012
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3ZQH
| Structure of Tetracycline repressor in complex with inducer peptide- TIP3 | Descriptor: | 1,2-ETHANEDIOL, INDUCER PEPTIDE TIP3, TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, ... | Authors: | Sevvana, M, Goeke, D, Stoeckle, C, Kaspar, D, Grubmueller, S, Goetz, C, Wimmer, C, Berens, C, Klotzsche, M, Muller, Y.A, Hillen, W. | Deposit date: | 2011-06-09 | Release date: | 2011-12-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | An Exclusive Alpha/Beta Code Directs Allostery in Tetr-Peptide Complexes. J.Mol.Biol., 416, 2012
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2FJ1
| Crystal Structure Analysis of Tet Repressor (class D) in Complex with 7-Chlortetracycline-Nickel(II) | Descriptor: | 7-CHLOROTETRACYCLINE, CHLORIDE ION, NICKEL (II) ION, ... | Authors: | Orth, P, Saenger, W, Palm, G.J, Hinrichs, W. | Deposit date: | 2005-12-30 | Release date: | 2007-01-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex. J.Biol.Inorg.Chem., 13, 2008
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2TCT
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2XB5
| Tet repressor (class D) in complex with 7-Iodotetracycline | Descriptor: | 7-IODOTETRACYCLINE, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Kisker, C, Saenger, W, Hinrichs, W. | Deposit date: | 2010-04-05 | Release date: | 2010-10-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance. Science, 264, 1994
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