3LSW
| Aniracetam bound to the ligand binding domain of GluA3 | Descriptor: | 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, GLUTAMIC ACID, GluA2 S1S2 domain, ... | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2010-02-13 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.752 Å) | Cite: | Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors. J.Med.Chem., 53, 2010
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3DLN
| Crystal structure of the binding domain of the AMPA subunit GluR3 bound to glutamate | Descriptor: | GLUTAMIC ACID, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E. | Deposit date: | 2008-06-27 | Release date: | 2008-11-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structure of the S1S2 glutamate binding domain of GLuR3. Proteins, 75, 2008
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3DP4
| Crystal structure of the binding domain of the AMPA subunit GluR3 bound to AMPA | Descriptor: | (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E. | Deposit date: | 2008-07-07 | Release date: | 2008-11-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structure of the S1S2 glutamate binding domain of GLuR3. Proteins, 75, 2008
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3DP6
| Crystal structure of the binding domain of the AMPA subunit GluR2 bound to glutamate | Descriptor: | GLUTAMIC ACID, Glutamate receptor 2, ZINC ION | Authors: | Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E. | Deposit date: | 2008-07-07 | Release date: | 2008-11-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structure of the S1S2 glutamate binding domain of GLuR3. Proteins, 75, 2008
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3H03
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3H06
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3LSX
| Piracetam bound to the ligand binding domain of GluA3 | Descriptor: | 2-(2-oxopyrrolidin-1-yl)acetamide, GLUTAMIC ACID, GluA3 S1S2 domain, ... | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2010-02-13 | Release date: | 2011-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.006 Å) | Cite: | Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors. J.Med.Chem., 53, 2010
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3LSF
| Piracetam bound to the ligand binding domain of GluA2 | Descriptor: | 2-(2-oxopyrrolidin-1-yl)acetamide, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | Deposit date: | 2010-02-12 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.851 Å) | Cite: | Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors. J.Med.Chem., 53, 2010
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3LSL
| Piracetam bound to the ligand binding domain of GluA2 (flop form) | Descriptor: | 2-(2-oxopyrrolidin-1-yl)acetamide, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2010-02-12 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.122 Å) | Cite: | Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors. J.Med.Chem., 53, 2010
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3M3F
| PEPA bound to the ligand binding domain of GluA3 (flop form) | Descriptor: | 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide, GLUTAMIC ACID, Glutamate receptor 3, ... | Authors: | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | Deposit date: | 2010-03-09 | Release date: | 2010-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA. Biochemistry, 49, 2010
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3M3K
| Ligand binding domain (S1S2) of GluA3 (flop) | Descriptor: | GLUTAMIC ACID, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | Deposit date: | 2010-03-09 | Release date: | 2010-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.793 Å) | Cite: | Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA. Biochemistry, 49, 2010
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4GXS
| Ligand binding domain of GluA2 (AMPA/glutamate receptor) bound to (-)-kaitocephalin | Descriptor: | (5R)-2-[(1S,2R)-2-amino-2-carboxy-1-hydroxyethyl]-5-{(2S)-2-carboxy-2-[(3,5-dichloro-4-hydroxybenzoyl)amino]ethyl}-L-proline, Glutamate receptor 2, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-09-04 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9634 Å) | Cite: | The structure of (-)-kaitocephalin bound to the ligand binding domain of the (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/glutamate receptor, GluA2. J.Biol.Chem., 287, 2012
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3T9V
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3T9X
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3T96
| Iodowillardiine bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 | Descriptor: | 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2, ZINC ION | Authors: | Ahmed, A.H, Wang, S, Chuang, H.H, Oswald, R.E. | Deposit date: | 2011-08-02 | Release date: | 2011-08-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.872 Å) | Cite: | Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
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3T9H
| Kainate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 | Descriptor: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, ZINC ION | Authors: | Ahmed, A.H, Wang, S, Chuang, H.H, Oswald, R.E. | Deposit date: | 2011-08-02 | Release date: | 2011-08-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.015 Å) | Cite: | Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
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3T93
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3T9U
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4F29
| Quisqualate bound to the ligand binding domain of GluA3i | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-05-07 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.749 Å) | Cite: | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F1Y
| CNQX bound to the ligand binding domain of GluA3 | Descriptor: | 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-05-07 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F2Q
| Quisqualate bound to the D655A mutant of the ligand binding domain of GluA3 | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-05-08 | Release date: | 2012-05-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F3B
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4F31
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4F39
| Kainate bound to the ligand binding domain of GluA3 | Descriptor: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-05-09 | Release date: | 2012-05-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.834 Å) | Cite: | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F22
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