7UXU
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![BU of 7uxu by Molmil](/molmil-images/mine/7uxu) | CryoEM structure of the TIR domain from AbTir in complex with 3AD | Descriptor: | Molecular chaperone Tir, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(8-azanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | Authors: | Li, S, Nanson, J.D, Manik, M.K, Gu, W, Landsberg, M.J, Ve, T, Kobe, B. | Deposit date: | 2022-05-06 | Release date: | 2022-09-07 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. Science, 377, 2022
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8T60
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4M57
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![BU of 4m57 by Molmil](/molmil-images/mine/4m57) | Crystal structure of the pentatricopeptide repeat protein PPR10 from maize | Descriptor: | Chloroplast pentatricopeptide repeat protein 10 | Authors: | Yin, P, Li, Q, Yan, C, Liu, Y, Yan, N. | Deposit date: | 2013-08-08 | Release date: | 2013-10-30 | Last modified: | 2013-12-18 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature, 504, 2013
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4M59
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![BU of 4m59 by Molmil](/molmil-images/mine/4m59) | Crystal structure of the pentatricopeptide repeat protein PPR10 in complex with an 18-nt psaJ RNA element | Descriptor: | Chloroplast pentatricopeptide repeat protein 10, PHOSPHATE ION, psaJ RNA | Authors: | Yin, P, Li, Q, Yan, C, Liu, Y, Yan, N. | Deposit date: | 2013-08-08 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature, 504, 2013
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5U2M
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![BU of 5u2m by Molmil](/molmil-images/mine/5u2m) | Crystal structure of human NAMPT with A-1293201 | Descriptor: | N-[4-({[(3S)-oxolan-3-yl]methyl}carbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide, Nicotinamide phosphoribosyltransferase, SULFATE ION | Authors: | Longenecker, K.L, Raich, D, Korepanova, A.V. | Deposit date: | 2016-11-30 | Release date: | 2017-06-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Mol. Cancer Ther., 16, 2017
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5U2N
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![BU of 5u2n by Molmil](/molmil-images/mine/5u2n) | Crystal structure of human NAMPT with A-1326133 | Descriptor: | N-{4-[1-(2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, SULFATE ION | Authors: | Longenecker, K.L, Raich, D, Korepanova, A.V. | Deposit date: | 2016-11-30 | Release date: | 2017-06-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Mol. Cancer Ther., 16, 2017
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3QT0
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![BU of 3qt0 by Molmil](/molmil-images/mine/3qt0) | Revealing a steroid receptor ligand as a unique PPARgamma agonist | Descriptor: | 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, Nuclear receptor coactivator 1 peptide, Peroxisome proliferator-activated receptor gamma | Authors: | Rong, H. | Deposit date: | 2011-02-22 | Release date: | 2012-02-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.496 Å) | Cite: | Revealing a steroid receptor ligand as a unique PPAR gamma agonist. Cell Res., 22, 2012
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3L3M
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![BU of 3l3m by Molmil](/molmil-images/mine/3l3m) | PARP complexed with A927929 | Descriptor: | 2-{2-fluoro-4-[(2S)-piperidin-2-yl]phenyl}-1H-benzimidazole-7-carboxamide, Poly [ADP-ribose] polymerase 1 | Authors: | Park, C.H. | Deposit date: | 2009-12-17 | Release date: | 2010-06-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor. J.Med.Chem., 53, 2010
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3L3L
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![BU of 3l3l by Molmil](/molmil-images/mine/3l3l) | PARP complexed with A906894 | Descriptor: | 3-oxo-2-piperidin-4-yl-2,3-dihydro-1H-isoindole-4-carboxamide, Poly [ADP-ribose] polymerase 1 | Authors: | Park, C.H. | Deposit date: | 2009-12-17 | Release date: | 2010-12-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg.Med.Chem.Lett., 20, 2010
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6LJJ
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![BU of 6ljj by Molmil](/molmil-images/mine/6ljj) | Swine dUTPase in complex with alpha,beta-iminodUTP and magnesium ion | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 1, ... | Authors: | Liang, R, Peng, G.Q. | Deposit date: | 2019-12-16 | Release date: | 2020-11-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development. J.Biol.Chem., 296, 2020
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8T9D
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![BU of 8t9d by Molmil](/molmil-images/mine/8t9d) | CryoEM structure of TR-TRAP | Descriptor: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | Authors: | Zhao, H, Asturias, F. | Deposit date: | 2023-06-23 | Release date: | 2024-07-03 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (4.66 Å) | Cite: | An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II. Mol.Cell, 84, 2024
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6LIS
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![BU of 6lis by Molmil](/molmil-images/mine/6lis) | ASFV dUTPase in complex with dUMP | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, E165R | Authors: | Liang, R, Peng, G.Q. | Deposit date: | 2019-12-12 | Release date: | 2020-11-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development. J.Biol.Chem., 296, 2020
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6LJ3
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6LJO
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![BU of 6ljo by Molmil](/molmil-images/mine/6ljo) | African swine fever virus dUTPase | Descriptor: | E165R | Authors: | Liang, R, Peng, G.Q. | Deposit date: | 2019-12-17 | Release date: | 2020-11-11 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development. J.Biol.Chem., 296, 2020
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5GMV
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![BU of 5gmv by Molmil](/molmil-images/mine/5gmv) | LC3B-FUNDC1 complex | Descriptor: | Microtubule-associated proteins 1A/1B light chain 3B, Peptide from FUN14 domain-containing protein 1 | Authors: | Lv, M, Wang, C, Li, F. | Deposit date: | 2016-07-17 | Release date: | 2017-03-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy Protein Cell, 8, 2017
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6BM0
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![BU of 6bm0 by Molmil](/molmil-images/mine/6bm0) | Cryo-EM structure of human CPSF-160-WDR33 complex at 3.8 A resolution | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | Authors: | Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. | Deposit date: | 2017-11-12 | Release date: | 2017-11-22 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8WU2
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![BU of 8wu2 by Molmil](/molmil-images/mine/8wu2) | Crystal structure of RNA-dependent RNA polymerases from Jingmen tick virus | Descriptor: | RNA polymerase, SELENIUM ATOM | Authors: | Liu, Z, Han, P, Peng, Q, Qi, J. | Deposit date: | 2023-10-20 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of RNA-dependent RNA polymerases from Jingmen tick virus and Alongshan virus HLIFE, 2, 2024
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6BLY
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![BU of 6bly by Molmil](/molmil-images/mine/6bly) | Cryo-EM structure of human CPSF-160-WDR33 complex at 3.36A resolution | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | Authors: | Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. | Deposit date: | 2017-11-12 | Release date: | 2017-11-22 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8WU3
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8XB8
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![BU of 8xb8 by Molmil](/molmil-images/mine/8xb8) | The structure of ASFV A137R | Descriptor: | A137R | Authors: | Li, C, Song, H, Gao, G.F. | Deposit date: | 2023-12-06 | Release date: | 2024-01-31 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | African swine fever virus A137R assembles into a dodecahedron cage. J.Virol., 98, 2024
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5H5N
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4JWF
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![BU of 4jwf by Molmil](/molmil-images/mine/4jwf) | Crystal structure of spTrm10(74)-SAH complex | Descriptor: | ACETIC ACID, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase | Authors: | Yan, W, Shao, Z. | Deposit date: | 2013-03-27 | Release date: | 2013-10-16 | Last modified: | 2014-02-12 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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4JWH
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![BU of 4jwh by Molmil](/molmil-images/mine/4jwh) | Crystal structure of spTrm10(Full length)-SAH complex | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase | Authors: | Yan, W, Shao, Z. | Deposit date: | 2013-03-27 | Release date: | 2013-10-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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4JWJ
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![BU of 4jwj by Molmil](/molmil-images/mine/4jwj) | Crystal structure of scTrm10(84)-SAH complex | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | Authors: | Yan, W, Shao, Z. | Deposit date: | 2013-03-27 | Release date: | 2013-10-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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4JWG
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![BU of 4jwg by Molmil](/molmil-images/mine/4jwg) | Crystal structure of spTrm10(74) | Descriptor: | ACETIC ACID, tRNA (guanine(9)-N1)-methyltransferase | Authors: | Yan, W, Shao, Z. | Deposit date: | 2013-03-27 | Release date: | 2013-10-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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