1NP6
 
 | | Crystal structure of Escherichia coli MobB | | Descriptor: | Molybdopterin-guanine dinucleotide biosynthesis protein B, SULFATE ION | | Authors: | McLuskey, K, Harrison, J.A, Schuttelkopf, A.W, Boxer, D.H, Hunter, W.N. | | Deposit date: | 2003-01-17 | | Release date: | 2003-04-29 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Insight into the role of Escherichia coli MobB in Molybdenum cofactor biosynthesis based on the high resolution crystal structure
J.Biol.Chem., 278, 2003
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1O73
 | | Tryparedoxin from Trypanosoma brucei | | Descriptor: | TRYPAREDOXIN | | Authors: | Gabrielsen, M, Alphey, M.S, Bond, C.S, Hunter, W.N. | | Deposit date: | 2002-10-23 | | Release date: | 2003-04-24 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Tryparedoxins from Crithidia Fasciculata and Trypanosoma Brucei: Photoreduction of the Redox Disulfide Using Synchrotron Radiation and Evidence for a Conformational Switch Implicated in Function
J.Biol.Chem., 278, 2003
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1OC8
 | | TRYPAREDOXIN II FROM C.FASCICULATA SOLVED BY MR | | Descriptor: | SULFATE ION, TRYPAREDOXIN II | | Authors: | Leonard, G.A, Micossi, E, Hunter, W.N. | | Deposit date: | 2003-02-07 | | Release date: | 2003-04-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Tryparedoxins from Crithidia Fasciculata and Trypanosoma Brucei: Photoreduction of the Redox Disulfide Using Synchrotron Radiation and Evidence for a Conformational Switch Implicated in Function
J.Biol.Chem., 278, 2003
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1O7L
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1QNH
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1QNG
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1OKG
 | | 3-mercaptopyruvate sulfurtransferase from Leishmania major | | Descriptor: | CALCIUM ION, POSSIBLE 3-MERCAPTOPYRUVATE SULFURTRANSFERASE, SULFITE ION | | Authors: | Alphey, M.S, Hunter, W.N. | | Deposit date: | 2003-07-24 | | Release date: | 2003-09-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Crystal Structure of Leishmania Major 3-Mercaptopyruvate Sulfurtransferase: A Three-Domain Architecture with a Serine Protease-Like Triad at the Active Site
J.Biol.Chem., 278, 2003
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1OJ4
 | | Ternary complex of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | | Descriptor: | 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, CHLORIDE ION, ... | | Authors: | Miallau, L, Alphey, M.S, Hunter, W.N. | | Deposit date: | 2003-06-30 | | Release date: | 2003-07-31 | | Last modified: | 2019-10-16 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Biosynthesis of Isoprenoids: Crystal Structure of 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase
Proc.Natl.Acad.Sci.USA, 100, 2003
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1GUS
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1GY8
 | | Trypanosoma brucei UDP-galactose 4' epimerase | | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-GALACTOSE 4-EPIMERASE, URIDINE-5'-DIPHOSPHATE | | Authors: | Shaw, M.P, Bond, C.S, Hunter, W.N. | | Deposit date: | 2002-04-21 | | Release date: | 2003-05-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | High-Resolution Crystal Structure of Trypanosoma Brucei Udp-Galactose 4'-Epimerase: A Potential Target for Structure-Based Development of Novel Trypanocides
Mol.Biochem.Parasitol., 126, 2003
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1GXF
 | | CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH THE INHIBITOR QUINACRINE MUSTARD | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, MALEIC ACID, QUINACRINE MUSTARD, ... | | Authors: | Bond, C.S, Peterson, M.R, Vickers, T.J, Fairlamb, A.H, Hunter, W.N. | | Deposit date: | 2002-04-04 | | Release date: | 2004-05-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Two Interacting Binding Sites for Quinacrine Derivatives in the Active Site of Trypanothione Reductase: A Template for Drug Design
J.Biol.Chem., 279, 2004
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1GVF
 | | Structure of tagatose-1,6-bisphosphate aldolase | | Descriptor: | 1,2-ETHANEDIOL, PHOSPHOGLYCOLOHYDROXAMIC ACID, SODIUM ION, ... | | Authors: | Hall, D.R, Hunter, W.N. | | Deposit date: | 2002-02-11 | | Release date: | 2002-06-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Structure of Tagatose-1,6-Bisphosphate Aldolase; Insight Into Chiral Discrimination, Mechanism and Specificity of Class II Aldolases
J.Biol.Chem., 277, 2002
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1H3M
 | | Structure of 4-diphosphocytidyl-2C-methyl-D-erythritol synthetase | | Descriptor: | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLORIDE ION, PENTANE-1,5-DIAMINE | | Authors: | Kemp, L.E, Bond, C.S, Hunter, W.N. | | Deposit date: | 2002-09-10 | | Release date: | 2003-08-01 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of a Tetragonal Crystal Form of Escherichia Coli 2-C-Methyl-D-Erythritol 4-Phosphate Cytidylyltransferase
Acta Crystallogr.,Sect.D, 59, 2003
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1GUN
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1GUG
 | | MopII from Clostridium pasteurianum complexed with tungstate | | Descriptor: | CHLORIDE ION, MOLYBDATE BINDING PROTEIN II, SODIUM ION, ... | | Authors: | Schuettelkopf, A.W, Harrison, J.A, Hunter, W.N. | | Deposit date: | 2002-01-25 | | Release date: | 2002-02-08 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Passive Acquisition of Ligand by the Mopii Molbindin from Clostridium Pasteurianum: Structures of Apo and Oxyanion-Bound Forms
J.Biol.Chem., 277, 2002
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1HH1
 | | THE STRUCTURE OF HJC, A HOLLIDAY JUNCTION RESOLVING ENZYME FROM SULFOLOBUS SOLFATARICUS | | Descriptor: | HOLLIDAY JUNCTION RESOLVING ENZYME HJC | | Authors: | Bond, C.S, Kvaratskhelia, M, Richard, D, White, M.F, Hunter, W.N. | | Deposit date: | 2000-12-18 | | Release date: | 2001-04-06 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structure of Hjc, a Holliday Junction Resolvase, from Sulfolobus Solfataricus
Proc.Natl.Acad.Sci.USA, 98, 2001
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1GUT
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1GX1
 | | Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase | | Descriptor: | 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE, CYTIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... | | Authors: | Kemp, L.E, Bond, C.S, Hunter, W.N. | | Deposit date: | 2002-03-26 | | Release date: | 2002-04-03 | | Last modified: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of 2C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase: An Essential Enzyme for Isoprenoid Biosynthesis and Target for Antimicrobial Drug Development
Proc.Natl.Acad.Sci.USA, 99, 2002
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1H9S
 | | Molybdate bound complex of Dimop domain of ModE from E.coli | | Descriptor: | MOLYBDATE ION, MOLYBDENUM TRANSPORT PROTEIN MODE | | Authors: | Gourley, D.G, Hunter, W.N. | | Deposit date: | 2001-03-19 | | Release date: | 2001-06-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Oxyanion Binding Alters Conformational and Quaternary Structure of the C-Terminal Domain of the Transcriptional Regulator Mode; Implications for Molybdate-Dependant Regulation, Signalling, Storage and Transport
J.Biol.Chem., 276, 2001
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1H48
 | | The structure of 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase in complex with CMP and product | | Descriptor: | 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE, 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE, CYTIDINE-5'-MONOPHOSPHATE, ... | | Authors: | Kemp, L.E, Alphey, M.S, Bond, C.S, Hunter, W.N. | | Deposit date: | 2003-02-24 | | Release date: | 2004-12-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Identification of Isoprenoids that Bind in the Intersubunit Cavity of Escherichia Coli 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase by Complementary Biophysical Methods
Acta Crystallogr.,Sect.D, 61, 2005
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1H9R
 | | Tungstate bound complex Dimop domain of ModE from E.coli | | Descriptor: | MOLYBDENUM TRANSPORT PROTEIN MODE, NICKEL (II) ION, TUNGSTATE(VI)ION | | Authors: | Gourley, D.G, Hunter, W.N. | | Deposit date: | 2001-03-19 | | Release date: | 2001-06-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Oxyanion Binding Alters Conformational and Quaternary Structure of the C-Terminal Domain of the Transcriptional Regulator Mode; Implications for Molybdate-Dependant Regulation, Signalling, Storage and Transport
J.Biol.Chem., 276, 2001
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1GUO
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1GYN
 | | Class II fructose 1,6-bisphosphate aldolase with Cadmium (not Zinc) in the active site | | Descriptor: | CADMIUM ION, FRUCTOSE-BISPHOSPHATE ALDOLASE II | | Authors: | Hall, D.R, Kemp, L.E, Leonard, G.A, Berry, A, Hunter, W.N. | | Deposit date: | 2002-04-27 | | Release date: | 2003-02-26 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Organization of Divalent Cations in the Active Site of Cadmium Escherichia Coli Fructose 1,6-Bisphosphate Aldolase
Acta Crystallogr.,Sect.D, 59, 2003
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1E92
 | | Pteridine reductase 1 from Leishmania major complexed with NADP+ and dihydrobiopterin | | Descriptor: | 1,2-ETHANEDIOL, 7,8-DIHYDROBIOPTERIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Schuettelkopf, A.W, Hunter, W.N. | | Deposit date: | 2000-10-04 | | Release date: | 2001-10-05 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Pteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites
Nat.Struct.Biol., 8, 2001
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1E9W
 | | Structure of the macrocycle thiostrepton solved using the anomalous dispersive contribution from sulfur | | Descriptor: | THIOSTREPTON | | Authors: | Bond, C.S, Shaw, M.P, Alphey, M.S, Hunter, W.N. | | Deposit date: | 2000-10-27 | | Release date: | 2001-03-23 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.02 Å) | | Cite: | Structure of the Macrocycle Thiostrepton Solved Using the Anomalous Dispersive Contribution from Sulfur
Acta Crystallogr.,Sect.D, 57, 2001
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