4FQY
 
 | | Crystal structure of broadly neutralizing antibody CR9114 bound to H3 influenza hemagglutinin | | Descriptor: | Antibody CR9114 heavy chain, Antibody CR9114 light chain, Hemagglutinin HA1, ... | | Authors: | Ekiert, D.C, Dreyfus, C, Wilson, I.A. | | Deposit date: | 2012-06-25 | | Release date: | 2012-08-22 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (5.253 Å) | | Cite: | Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
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4FQI
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4HYX
 | | Crystal Structure Analysis of the Bacteriorhodopsin in Facial Amphiphile-4 DMPC Bicelle | | Descriptor: | Bacteriorhodopsin, DECANE, GLYCEROL, ... | | Authors: | Lee, S, Stout, C.D, Zhang, Q. | | Deposit date: | 2012-11-14 | | Release date: | 2013-03-20 | | Last modified: | 2013-05-22 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4HWL
 | | Crystal Structure Analysis of the Bacteriorhodopsin in Facial Amphiphile-7 DMPC Bicelle | | Descriptor: | Bacteriorhodopsin, GLYCEROL, HEPTANE, ... | | Authors: | Lee, S, Stout, C.D, Zhang, Q. | | Deposit date: | 2012-11-08 | | Release date: | 2013-03-20 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4GSD
 | | H5.3 Fab Structure | | Descriptor: | H5.3 Fab Heavy Chain, H5.3 Fab Light Chain | | Authors: | Spiller, B.W, Winarski, K.L. | | Deposit date: | 2012-08-27 | | Release date: | 2013-08-21 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.251 Å) | | Cite: | Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses.
J.Clin.Invest., 123, 2013
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4GE4
 | | Kynurenine Aminotransferase II Inhibitors | | Descriptor: | (5-hydroxy-4-{[(1-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | | Authors: | Pandit, J. | | Deposit date: | 2012-08-01 | | Release date: | 2012-11-07 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.
ACS Med Chem Lett, 4, 2013
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4I54
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4JL9
 | | Crystal structure of mouse TBK1 bound to BX795 | | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1 | | Authors: | Li, P, Shu, C. | | Deposit date: | 2013-03-12 | | Release date: | 2013-06-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.0999 Å) | | Cite: | Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity.
Structure, 21, 2013
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4JY6
 | | Crystal structure of human Fab PGT123, a broadly reactive and potent HIV-1 neutralizing antibody | | Descriptor: | GLYCEROL, PGT123 heavy chain, PGT123 light chain, ... | | Authors: | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | | Deposit date: | 2013-03-29 | | Release date: | 2013-05-08 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans.
Plos Pathog., 9, 2013
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4IWD
 | | Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-8033 analog | | Descriptor: | 1-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-N-(pyridin-2-ylmethyl)methanesulfonamide, Hepatocyte growth factor receptor | | Authors: | Soisson, S.M, Northrup, A, Rickert, K, Patel, S, Allison, T. | | Deposit date: | 2013-01-23 | | Release date: | 2013-12-11 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
J.Med.Chem., 56, 2013
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4JY5
 | | Crystal structure of human Fab PGT122, a broadly reactive and potent HIV-1 neutralizing antibody | | Descriptor: | GLYCEROL, PGT122 heavy chain, PGT122 light chain | | Authors: | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | | Deposit date: | 2013-03-29 | | Release date: | 2013-05-08 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
Plos Pathog., 9, 2013
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4JKK
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4GEB
 | | Kynurenine Aminotransferase II Inhibitors | | Descriptor: | (5-hydroxy-4-{[(7-hydroxy-6-oxo-2-phenyl-6,7-dihydro-2H-pyrazolo[3,4-b]pyridin-5-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, ... | | Authors: | Pandit, J. | | Deposit date: | 2012-08-01 | | Release date: | 2013-03-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.
Bioorg.Med.Chem.Lett., 23, 2013
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4JKM
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4JLC
 | | Crystal structure of mouse TBK1 bound to SU6668 | | Descriptor: | 3-{2,4-dimethyl-5-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid, Serine/threonine-protein kinase TBK1 | | Authors: | Li, P. | | Deposit date: | 2013-03-12 | | Release date: | 2013-06-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity.
Structure, 21, 2013
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4JY4
 | | Crystal structure of human Fab PGT121, a broadly reactive and potent HIV-1 neutralizing antibody | | Descriptor: | GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PGT121 heavy chain, ... | | Authors: | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | | Deposit date: | 2013-03-29 | | Release date: | 2013-05-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
Plos Pathog., 9, 2013
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4I53
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4JM2
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4JM4
 | | Crystal Structure of PGT 135 Fab | | Descriptor: | PGT 135 Heavy Chain, PGT 135 Light Chain | | Authors: | Kong, L, Wilson, I.A. | | Deposit date: | 2013-03-13 | | Release date: | 2013-05-29 | | Last modified: | 2013-07-17 | | Method: | X-RAY DIFFRACTION (1.751 Å) | | Cite: | Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Nat.Struct.Mol.Biol., 20, 2013
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4JPJ
 | | Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6 | | Authors: | Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A. | | Deposit date: | 2013-03-19 | | Release date: | 2013-04-10 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Rational HIV immunogen design to target specific germline B cell receptors.
Science, 340, 2013
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4JKL
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4JPI
 | | Crystal structure of a putative VRC01 germline precursor Fab | | Descriptor: | GLYCEROL, Putative VRC01 germline Fab heavy chain, Putative VRC01 germline Fab light chain | | Authors: | Julien, J.-P, Diwanji, D.C, Jardine, J, Schief, W.R, Wilson, I.A. | | Deposit date: | 2013-03-19 | | Release date: | 2013-04-10 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Rational HIV immunogen design to target specific germline B cell receptors.
Science, 340, 2013
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4JIO
 | | Bro1 V domain and ubiquitin | | Descriptor: | BRO1, Ubiquitin | | Authors: | Pashkova, N, Gakhar, L, Piper, R.C. | | Deposit date: | 2013-03-06 | | Release date: | 2013-06-19 | | Last modified: | 2013-07-10 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | The yeast alix homolog bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes.
Dev.Cell, 25, 2013
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4JJY
 | | Alix V domain | | Descriptor: | Programmed cell death 6-interacting protein | | Authors: | Pashkova, N, Gakhar, L, Yu, L, Piper, R.C. | | Deposit date: | 2013-03-08 | | Release date: | 2013-06-19 | | Last modified: | 2013-07-10 | | Method: | X-RAY DIFFRACTION (6.503 Å) | | Cite: | The yeast alix homolog bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes.
Dev.Cell, 25, 2013
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4JPK
 | | Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain eOD-GT6 in complex with a putative VRC01 germline precursor Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6, ... | | Authors: | Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A. | | Deposit date: | 2013-03-19 | | Release date: | 2013-04-10 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Rational HIV immunogen design to target specific germline B cell receptors.
Science, 340, 2013
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