4GEB
Kynurenine Aminotransferase II Inhibitors
Summary for 4GEB
Entry DOI | 10.2210/pdb4geb/pdb |
Related | 4GDY 4GE4 4GE7 4GE9 |
Descriptor | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (5-hydroxy-4-{[(7-hydroxy-6-oxo-2-phenyl-6,7-dihydro-2H-pyrazolo[3,4-b]pyridin-5-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, SULFATE ION, ... (4 entities in total) |
Functional Keywords | aminotransferase, irreversible inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion (Potential): Q8N5Z0 |
Total number of polymer chains | 2 |
Total formula weight | 99231.15 |
Authors | Pandit, J. (deposition date: 2012-08-01, release date: 2013-03-20, Last modification date: 2023-09-13) |
Primary citation | Dounay, A.B.,Anderson, M.,Bechle, B.M.,Evrard, E.,Gan, X.,Kim, J.Y.,McAllister, L.A.,Pandit, J.,Rong, S.,Salafia, M.A.,Tuttle, J.B.,Zawadzke, L.E.,Verhoest, P.R. PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency. Bioorg.Med.Chem.Lett., 23:1961-1966, 2013 Cited by PubMed: 23466229DOI: 10.1016/j.bmcl.2013.02.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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