4GEB
Kynurenine Aminotransferase II Inhibitors
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006103 | biological_process | 2-oxoglutarate metabolic process |
A | 0006536 | biological_process | glutamate metabolic process |
A | 0008483 | molecular_function | transaminase activity |
A | 0009058 | biological_process | biosynthetic process |
A | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0033512 | biological_process | L-lysine catabolic process to acetyl-CoA via saccharopine |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0047315 | molecular_function | kynurenine-glyoxylate transaminase activity |
A | 0047536 | molecular_function | 2-aminoadipate transaminase activity |
A | 0047958 | molecular_function | glycine:2-oxoglutarate aminotransferase activity |
A | 0050094 | molecular_function | methionine-glyoxylate transaminase activity |
A | 0070189 | biological_process | kynurenine metabolic process |
A | 1901605 | biological_process | alpha-amino acid metabolic process |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0006103 | biological_process | 2-oxoglutarate metabolic process |
B | 0006536 | biological_process | glutamate metabolic process |
B | 0008483 | molecular_function | transaminase activity |
B | 0009058 | biological_process | biosynthetic process |
B | 0016212 | molecular_function | kynurenine-oxoglutarate transaminase activity |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0033512 | biological_process | L-lysine catabolic process to acetyl-CoA via saccharopine |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0047315 | molecular_function | kynurenine-glyoxylate transaminase activity |
B | 0047536 | molecular_function | 2-aminoadipate transaminase activity |
B | 0047958 | molecular_function | glycine:2-oxoglutarate aminotransferase activity |
B | 0050094 | molecular_function | methionine-glyoxylate transaminase activity |
B | 0070189 | biological_process | kynurenine metabolic process |
B | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE 0LD A 501 |
Chain | Residue |
A | GLY116 |
A | SER262 |
A | LYS263 |
A | ARG270 |
A | ARG399 |
A | HOH807 |
A | HOH856 |
B | ILE19 |
B | GLY39 |
B | LEU40 |
B | TYR74 |
A | SER117 |
B | SER75 |
A | GLN118 |
A | TYR142 |
A | ASN202 |
A | ASP230 |
A | PRO232 |
A | TYR233 |
A | SER260 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 502 |
Chain | Residue |
A | ARG177 |
A | TRP178 |
A | LYS188 |
A | ASN189 |
A | HOH703 |
A | HOH714 |
site_id | AC3 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE 0LD B 501 |
Chain | Residue |
A | GLY39 |
A | LEU40 |
A | TYR74 |
A | SER75 |
B | GLY116 |
B | SER117 |
B | GLN118 |
B | TYR142 |
B | ASN202 |
B | ASP230 |
B | PRO232 |
B | TYR233 |
B | SER260 |
B | SER262 |
B | LYS263 |
B | ARG270 |
B | ARG399 |
B | HOH792 |
B | HOH802 |
site_id | AC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE SO4 B 502 |
Chain | Residue |
A | GLN119 |
A | LYS123 |
A | SER291 |
A | THR292 |
B | GLN119 |
B | LYS123 |
B | SER291 |
B | THR292 |
B | HOH789 |
B | HOH1010 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 503 |
Chain | Residue |
B | ARG177 |
B | TRP178 |
B | LYS188 |
B | ASN189 |
B | HOH753 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 504 |
Chain | Residue |
A | HIS101 |
A | HOH742 |
B | ARG242 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
A | ARG20 | |
B | ARG399 | |
A | TYR74 | |
A | TYR142 | |
A | ASN202 | |
A | ARG399 | |
B | ARG20 | |
B | TYR74 | |
B | TYR142 | |
B | ASN202 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9WVM8 |
Chain | Residue | Details |
A | LYS69 | |
A | LYS179 | |
A | LYS422 | |
B | LYS69 | |
B | LYS179 | |
B | LYS422 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9WVM8 |
Chain | Residue | Details |
A | LYS263 | |
A | LYS339 | |
A | LYS367 | |
B | LYS263 | |
B | LYS339 | |
B | LYS367 |