4GE7
Kynurenine Aminotransferase II Inhibitors
Summary for 4GE7
Entry DOI | 10.2210/pdb4ge7/pdb |
Related | 4GDY 4GE4 4GE9 4GEB |
Descriptor | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (5-hydroxy-4-{[(1-hydroxy-2-oxo-6-phenoxy-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate (3 entities in total) |
Functional Keywords | aminotransferase, irreversible inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion (Potential): Q8N5Z0 |
Total number of polymer chains | 2 |
Total formula weight | 98930.98 |
Authors | Pandit, J. (deposition date: 2012-08-01, release date: 2012-11-07, Last modification date: 2023-12-06) |
Primary citation | Tuttle, J.B.,Anderson, M.,Bechle, B.M.,Campbell, B.M.,Chang, C.,Dounay, A.B.,Evrard, E.,Fonseca, K.R.,Gan, X.,Ghosh, S.,Horner, W.,James, L.C.,Kim, J.Y.,McAllister, L.A.,Pandit, J.,Parikh, V.D.,Rago, B.J.,Salafia, M.A.,Strick, C.A.,Zawadzke, L.E.,Verhoest, P.R. Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett, 4:37-40, 2013 Cited by PubMed: 24900560DOI: 10.1021/ml300237v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report