7YJ5
 
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7YJ7
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7EOS
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7EOR
 | | Structure of the human GluN1/GluN2A NMDA receptor in the glycine/glutamate/GNE-6901 bound state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-[(4-fluoranylphenoxy)methyl]-3-[(1~{R},2~{R})-2-(hydroxymethyl)cyclopropyl]-2-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one, Glutamate receptor ionotropic, ... | | Authors: | Wang, H, Zhu, S. | | Deposit date: | 2021-04-22 | | Release date: | 2021-06-30 | | Last modified: | 2021-08-18 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors.
Neuron, 109, 2021
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7VKH
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1FAD
 | | DEATH DOMAIN OF FAS-ASSOCIATED DEATH DOMAIN PROTEIN, RESIDUES 89-183 | | Descriptor: | PROTEIN (FADD PROTEIN) | | Authors: | Jeong, E.-J, Bang, S, Lee, T.H, Park, Y.-I, Sim, W.-S, Kim, K.-S. | | Deposit date: | 1999-03-23 | | Release date: | 1999-07-06 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | The solution structure of FADD death domain. Structural basis of death domain interactions of Fas and FADD.
J.Biol.Chem., 274, 1999
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7W26
 | | monolignol ferulate transferase | | Descriptor: | Ferulate monolignol transferase | | Authors: | Xi, L, Shuliu, D, Yue, F, Yi, Z. | | Deposit date: | 2021-11-22 | | Release date: | 2022-03-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Crystal structure of the plant feruloyl-coenzyme A monolignol transferase provides insights into the formation of monolignol ferulate conjugates.
Biochem.Biophys.Res.Commun., 594, 2022
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7WI0
 | | SARS-CoV-2 Omicron variant spike in complex with three human neutralizing antibodies | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IG c1437_light_IGLV1-40_IGLJ1, IG c934_light_IGKV1-5_IGKJ1, ... | | Authors: | Zheng, Q, Li, S, Sun, H, Zheng, Z, Wang, S. | | Deposit date: | 2022-01-01 | | Release date: | 2022-06-22 | | Method: | ELECTRON MICROSCOPY (3.82 Å) | | Cite: | Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron.
Cell Rep, 39, 2022
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7WHZ
 | | SARS-CoV-2 spike protein in complex with three human neutralizing antibodies | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IG c1437_light_IGLV1-40_IGLJ1, IG c934_light_IGKV1-5_IGKJ1, ... | | Authors: | Zheng, Q, Li, S, Sun, H, Zheng, Z, Wang, S. | | Deposit date: | 2022-01-01 | | Release date: | 2022-06-22 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron.
Cell Rep, 39, 2022
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7VKG
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7V12
 | | Factor XIa in Complex with Compound 2f | | Descriptor: | 5-[1-[(1~{R})-1-[5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]-6-fluoranyl-pyridin-2-amine, CITRIC ACID, Coagulation factor XIa light chain | | Authors: | Shaffer, P.L, Spurlino, J, Milligan, C.M. | | Deposit date: | 2022-05-11 | | Release date: | 2022-08-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.631 Å) | | Cite: | Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
J.Med.Chem., 65, 2022
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7V0Z
 | | Factor XIa in Complex with Compound 2a | | Descriptor: | Coagulation factor XIa light chain, methyl ~{N}-[4-[1-[(1~{R})-1-[5-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]phenyl]carbamate | | Authors: | Shaffer, P.L, Spurlino, J, Milligan, C.M. | | Deposit date: | 2022-05-11 | | Release date: | 2022-08-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
J.Med.Chem., 65, 2022
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7V10
 | | Factor XIa in Complex with Compound 2d | | Descriptor: | CITRIC ACID, Coagulation factor XIa light chain, methyl ~{N}-[4-[1-[(1~{R})-1-[5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]phenyl]carbamate | | Authors: | Shaffer, P.L, Spurlino, J, Milligan, C.M. | | Deposit date: | 2022-05-11 | | Release date: | 2022-08-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.798 Å) | | Cite: | Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
J.Med.Chem., 65, 2022
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7YIM
 | | Cryo-EM structure of human Alpha-fetoprotein | | Descriptor: | Alpha-fetoprotein | | Authors: | Liu, N, Liu, K, Wu, C, Liu, Z, Li, M, Wang, J, Wang, H.W. | | Deposit date: | 2022-07-17 | | Release date: | 2023-01-18 | | Last modified: | 2023-01-25 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Uniform thin ice on ultraflat graphene for high-resolution cryo-EM.
Nat.Methods, 20, 2023
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7Y3G
 | | Cryo-EM structure of a class A orphan GPCR | | Descriptor: | G-protein coupled receptor 12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Liu, Z.J, Hua, T, Li, H, Zhang, J.Y, Luo, F. | | Deposit date: | 2022-06-10 | | Release date: | 2023-06-07 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Structural insight into the constitutive activity of human orphan receptor GPR12.
Sci Bull (Beijing), 68, 2023
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7D1L
 | | complex structure of two RRM domains | | Descriptor: | Embryonic developmental protein tofu-6, Uncharacterized protein | | Authors: | Wang, X, Liao, S, Xu, C. | | Deposit date: | 2020-09-14 | | Release date: | 2021-08-25 | | Last modified: | 2021-10-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Molecular basis for PICS-mediated piRNA biogenesis and cell division.
Nat Commun, 12, 2021
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7D2Y
 | | complex of two RRM domains | | Descriptor: | Embryonic developmental protein tofu-6, RRM2, SULFATE ION | | Authors: | Wang, X, Liao, S, Xu, C. | | Deposit date: | 2020-09-17 | | Release date: | 2021-08-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Molecular basis for PICS-mediated piRNA biogenesis and cell division.
Nat Commun, 12, 2021
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7EJS
 | | Structure of ERH-2 bound to PICS-1 | | Descriptor: | Enhancer of rudimentary homolog 2,Protein pid-3 | | Authors: | Wang, X, Xu, C. | | Deposit date: | 2021-04-02 | | Release date: | 2021-08-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.387 Å) | | Cite: | Molecular basis for PICS-mediated piRNA biogenesis and cell division.
Nat Commun, 12, 2021
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7EJO
 | | Structure of ERH-2 bound to TOST-1 | | Descriptor: | Enhancer of rudimentary homolog 2, Enhancer of rudimentary homolog 2,Protein tost-1 | | Authors: | Wang, X, Xu, C. | | Deposit date: | 2021-04-02 | | Release date: | 2021-08-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.191 Å) | | Cite: | Molecular basis for PICS-mediated piRNA biogenesis and cell division.
Nat Commun, 12, 2021
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7E56
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7EBA
 | | Co-crystal of kurarinone with sEH | | Descriptor: | (2S)-2-[2,4-bis(oxidanyl)phenyl]-5-methoxy-8-[(2R)-5-methyl-2-prop-1-en-2-yl-hex-4-enyl]-7-oxidanyl-2,3-dihydrochromen-4-one, Bifunctional epoxide hydrolase 2 | | Authors: | Sun, C.P, Ma, X.C. | | Deposit date: | 2021-03-09 | | Release date: | 2022-03-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7FJ1
 | | Cryo-EM structure of pseudorabies virus C-capsid | | Descriptor: | Capsid vertex component 1, DNA packaging tegument protein UL25, Major capsid protein, ... | | Authors: | Zheng, Q, Li, S, Zha, Z, Sun, H. | | Deposit date: | 2021-08-02 | | Release date: | 2022-06-22 | | Method: | ELECTRON MICROSCOPY (4.43 Å) | | Cite: | Structures of pseudorabies virus capsids.
Nat Commun, 13, 2022
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7FJ3
 | | Cryo-EM structure of PRV A-capid | | Descriptor: | Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ... | | Authors: | Zheng, Q, Li, S, Zha, Z, Sun, H. | | Deposit date: | 2021-08-02 | | Release date: | 2022-06-22 | | Method: | ELECTRON MICROSCOPY (4.53 Å) | | Cite: | Structures of pseudorabies virus capsids.
Nat Commun, 13, 2022
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7EL6
 | | Structure of SMCR8 bound FEM1B | | Descriptor: | Protein fem-1 homolog B,Guanine nucleotide exchange protein SMCR8 | | Authors: | Zhao, S, Xu, C. | | Deposit date: | 2021-04-08 | | Release date: | 2021-05-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.802 Å) | | Cite: | Structural insights into SMCR8 C-degron recognition by FEM1B.
Biochem.Biophys.Res.Commun., 557, 2021
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7XGW
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