8PHI
 
 | | Crystal structure of prefusion-stabilized RSV F Variant DS-Cav1 in complex with Lonafarnib | | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, CALCIUM ION, ... | | Authors: | Rajak, M, Krey, T. | | Deposit date: | 2023-06-19 | | Release date: | 2024-02-21 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.289 Å) | | Cite: | Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
Nat Commun, 15, 2024
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5E6H
 | | A Linked Jumonji Domain of the KDM5A Lysine Demethylase | | Descriptor: | 2-OXOGLUTARIC ACID, GLYCEROL, Lysine-specific demethylase 5A, ... | | Authors: | Horton, J.R, Cheng, X. | | Deposit date: | 2015-10-09 | | Release date: | 2015-12-16 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.238 Å) | | Cite: | Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
J.Biol.Chem., 291, 2016
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4N88
 | | Crystal structure of Tse3-Tsi3 complex with calcium ion | | Descriptor: | CALCIUM ION, Uncharacterized protein | | Authors: | Shang, G.J. | | Deposit date: | 2013-10-17 | | Release date: | 2014-04-23 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
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4N80
 | | Crystal structure of Tse3-Tsi3 complex | | Descriptor: | CALCIUM ION, Uncharacterized protein, ZINC ION | | Authors: | Shang, G.J. | | Deposit date: | 2013-10-16 | | Release date: | 2014-04-23 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism
Mol.Microbiol., 92, 2014
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8YZC
 | | Structure of BA.2.86 spike protein in complex with ACE2. | | Descriptor: | Angiotensin-converting enzyme 2, Spike glycoprotein,Fibritin,Expression Tag | | Authors: | Wang, Y.J, Zang, X, Sun, L. | | Deposit date: | 2024-04-06 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3.
Nat Commun, 15, 2024
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6ABR
 | | Actin interacting protein 5 (Aip5, wild type) | | Descriptor: | Actin binding protein | | Authors: | Sun, J, Xie, Y, Toh, J.D.W, Hong, W, MIao, Y, Gao, Y.G. | | Deposit date: | 2018-07-23 | | Release date: | 2019-11-20 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.002 Å) | | Cite: | Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization.
Nat Commun, 10, 2019
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6W38
 | | Crystal structure of the FAM46C/Plk4 complex | | Descriptor: | Serine/threonine-protein kinase PLK4, Terminal nucleotidyltransferase 5C | | Authors: | Chen, H, Lu, D.F, Shang, G.J, Zhang, X.W. | | Deposit date: | 2020-03-09 | | Release date: | 2020-05-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (4.48 Å) | | Cite: | Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structure, 28, 2020
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6W3J
 | | Crystal structure of the FAM46C/Plk4/Cep192 complex | | Descriptor: | Centrosomal protein of 192 kDa, Serine/threonine-protein kinase PLK4, Terminal nucleotidyltransferase 5C | | Authors: | Chen, H, Lu, D.F, Shang, G.J, Zhang, X.W. | | Deposit date: | 2020-03-09 | | Release date: | 2020-05-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (4.385 Å) | | Cite: | Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structure, 28, 2020
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6W36
 | | Crystal structure of FAM46C | | Descriptor: | SULFATE ION, Terminal nucleotidyltransferase 5C | | Authors: | Shang, G.J, Zhang, X.W, Chen, H, Lu, D.F. | | Deposit date: | 2020-03-09 | | Release date: | 2020-05-06 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.854 Å) | | Cite: | Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structure, 28, 2020
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3IOP
 | | PDK-1 in complex with the inhibitor Compound-8i | | Descriptor: | 2-(5-{[(2R)-2-amino-3-phenylpropyl]oxy}pyridin-3-yl)-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine, 3-phosphoinositide-dependent protein kinase 1 | | Authors: | Olland, A.M. | | Deposit date: | 2009-08-14 | | Release date: | 2010-02-16 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1).
Eur.J.Med.Chem., 45, 2010
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8ZF0
 | | pRib-ADP bound OsEDS1-PAD4-ADR1 complex | | Descriptor: | EDS1, Lipase-like PAD4, RPW8 domain-containing protein, ... | | Authors: | Xu, W.Y, Zhang, Y. | | Deposit date: | 2024-05-07 | | Release date: | 2024-11-13 | | Last modified: | 2025-01-01 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | A canonical protein complex controls immune homeostasis and multipathogen resistance.
Science, 386, 2024
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6OGZ
 | | In situ structure of Rotavirus RNA-dependent RNA polymerase at transcript-elongated state | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Inner capsid protein VP2, RNA (5'-R(P*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*A)-3'), ... | | Authors: | Ding, K, Chang, T, Shen, W, Roy, P, Zhou, Z.H. | | Deposit date: | 2019-04-03 | | Release date: | 2019-05-22 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release.
Nat Commun, 10, 2019
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9JAL
 | | Cryo-EM structure of MPXV core protease in complex with compound A1 | | Descriptor: | A1ECM-DI8-ALA-ETA, Core protease I7 | | Authors: | Gao, Y, Xie, X, Lan, W, Wang, W, Yang, H. | | Deposit date: | 2024-08-25 | | Release date: | 2025-03-12 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Substrate recognition and cleavage mechanism of the monkeypox virus core protease.
Nature, 2025
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9JAN
 | | Cryo-EM structure of MPXV protease in complex with compound A4 | | Descriptor: | A1ECL-DI8-ALA-AEM, Core protease I7 | | Authors: | Gao, Y, Xie, X, Lan, W, Wang, W, Yang, H. | | Deposit date: | 2024-08-25 | | Release date: | 2025-03-12 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Substrate recognition and cleavage mechanism of the monkeypox virus core protease.
Nature, 2025
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9JAM
 | | Cryo-EM structure of MPXV core protease in complex with compound A3 | | Descriptor: | A1ECK-DI8-ALA-AEM, Core protease I7 | | Authors: | Gao, Y, Xie, X, Lan, W, Wang, W, Yang, H. | | Deposit date: | 2024-08-25 | | Release date: | 2025-03-12 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Substrate recognition and cleavage mechanism of the monkeypox virus core protease.
Nature, 2025
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9JAQ
 | | Cryo-EM structure of MPXV core protease in the apo-form | | Descriptor: | Core protease I7 | | Authors: | Lan, W, You, T, Li, D, Dong, X, Wang, H, Xu, J, Wang, W, Gao, Y, Yang, H. | | Deposit date: | 2024-08-25 | | Release date: | 2025-03-12 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Substrate recognition and cleavage mechanism of the monkeypox virus core protease.
Nature, 2025
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9KQV
 | | Cryo-EM structure of MPXV core protease in complex with aloxistatin(E64d) | | Descriptor: | Core protease I7, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate | | Authors: | Lan, W, You, T, Li, D, Dong, X, Wang, H, Xu, J, Wang, W, Gao, Y, Yang, H. | | Deposit date: | 2024-11-27 | | Release date: | 2025-03-12 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Substrate recognition and cleavage mechanism of the monkeypox virus core protease.
Nature, 2025
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5C9C
 | | CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND | | Descriptor: | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea, CHLORIDE ION, Serine/threonine-protein kinase B-raf | | Authors: | Edwards, T, Abendroth, J, Chun, L. | | Deposit date: | 2015-06-26 | | Release date: | 2015-07-15 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.
Cancer Cell, 28, 2015
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7WNU
 | | Mycobacterium tuberculosis Rnase J complex with 7nt RNA | | Descriptor: | RNA (5'-R(P*AP*AP*AP*AP*AP*AP*A)-3'), Ribonuclease J, ZINC ION | | Authors: | Li, J, Hu, J, Bao, L, Zhan, B, Li, Z. | | Deposit date: | 2022-01-19 | | Release date: | 2023-01-25 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural insights into RNase J that plays an essential role in Mycobacterium tuberculosis RNA metabolism
Nat Commun, 14, 2023
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7WNT
 | | RNase J from Mycobacterium tuberculosis | | Descriptor: | Ribonuclease J, ZINC ION | | Authors: | Li, J, Bao, L, Hu, J, Zhan, B, Li, Z. | | Deposit date: | 2022-01-19 | | Release date: | 2023-01-25 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Structural insights into RNase J that plays an essential role in Mycobacterium tuberculosis RNA metabolism
Nat Commun, 14, 2023
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8I5Z
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9KR6
 | | Cryo-EM structure of MPXV core protease in complex with the substrate derivative I-G18 | | Descriptor: | Core protease I7, Core protein VP8 | | Authors: | Lan, W, You, T, Li, D, Dong, X, Wang, H, Xu, J, Wang, W, Gao, Y, Yang, H. | | Deposit date: | 2024-11-27 | | Release date: | 2025-03-12 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Substrate recognition and cleavage mechanism of the monkeypox virus core protease.
Nature, 2025
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6W3I
 | | Crystal structure of a FAM46C mutant in complex with Plk4 | | Descriptor: | Serine/threonine-protein kinase PLK4, Terminal nucleotidyltransferase 5C | | Authors: | Chen, H, Shang, G.J, Lu, D.F, Zhang, X.W. | | Deposit date: | 2020-03-09 | | Release date: | 2020-05-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.802 Å) | | Cite: | Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structure, 28, 2020
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8WSP
 | | Crystal structure of SFTSV Gn and antibody SF5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab5-H, Ab5-L, ... | | Authors: | Chang, Z, Gao, F, Wu, Y. | | Deposit date: | 2023-10-17 | | Release date: | 2024-06-12 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8WSU
 | | Crystal structure of SFTSV Gc and antibody | | Descriptor: | Ab-H, Ab-L, Glycoprotein C | | Authors: | Chang, Z, Gao, F, Wu, Y. | | Deposit date: | 2023-10-17 | | Release date: | 2024-06-12 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model.
Proc.Natl.Acad.Sci.USA, 121, 2024
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