5MI3
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![BU of 5mi3 by Molmil](/molmil-images/mine/5mi3) | Structure of phosphorylated translation elongation factor EF-Tu from E. coli | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Talavera, A, Hendrix, J, Versees, W, De Gieter, S, Castro-Roa, D, Jurenas, D, Van Nerom, K, Vandenberk, N, Barth, A, De Greve, H, Hofkens, J, Zenkin, N, Loris, R, Garcia-Pino, A. | Deposit date: | 2016-11-27 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors. Sci Adv, 4, 2018
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5MI9
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![BU of 5mi9 by Molmil](/molmil-images/mine/5mi9) | Structure of the phosphomimetic mutant of the elongation factor EF-Tu T62E | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Talavera, A, Hendrix, J, Versees, W, De Gieter, S, Castro-Roa, D, Jurenas, D, Van Nerom, K, Vandenberk, N, Barth, A, De Greve, H, Hofkens, J, Zenkin, N, Loris, R, Garcia-Pino, A. | Deposit date: | 2016-11-27 | Release date: | 2017-12-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors. Sci Adv, 4, 2018
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2WRS
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![BU of 2wrs by Molmil](/molmil-images/mine/2wrs) | Crystal Structure of the Mono-Zinc Metallo-beta-lactamase VIM-4 from Pseudomonas aeruginosa | Descriptor: | BETA-LACTAMASE VIM-4, CITRATE ANION, CITRIC ACID, ... | Authors: | Lassaux, P, Hamel, M, Gulea, M, Delbruck, H, Traore, D.A.K, Mercuri, P.S, Horsfall, L, Dehareng, D, Gaumont, A.-C, Frere, J.-M, Ferrer, J.-L, Hoffmann, K, Galleni, M, Bebrone, C. | Deposit date: | 2009-09-02 | Release date: | 2010-06-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-Beta-Lactamases. J.Med.Chem., 53, 2010
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3UH8
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![BU of 3uh8 by Molmil](/molmil-images/mine/3uh8) | N-terminal domain of phage TP901-1 ORF48 | Descriptor: | ORF48 | Authors: | Veesler, D, Spinelli, S, Mahony, J, Lichiere, J, Blangy, S, Bricogne, G, Legrand, P, Ortiz-Lombardia, M, Campanacci, V.I, van Sinderen, D, Cambillau, C. | Deposit date: | 2011-11-03 | Release date: | 2012-05-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism. Proc.Natl.Acad.Sci.USA, 109, 2012
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3U6X
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![BU of 3u6x by Molmil](/molmil-images/mine/3u6x) | Phage TP901-1 baseplate tripod | Descriptor: | BPP, BROMIDE ION, ORF48 | Authors: | Veesler, D, Spinelli, S, Mahony, J, Lichiere, J, Blangy, S, Bricogne, G, Legrand, P, Ortiz-Lombardia, M, Campanacci, V.I, van Sinderen, D, Cambillau, C. | Deposit date: | 2011-10-13 | Release date: | 2012-07-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism. Proc.Natl.Acad.Sci.USA, 109, 2012
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3EAK
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![BU of 3eak by Molmil](/molmil-images/mine/3eak) | NbBCII10 humanized (FGLA mutant) | Descriptor: | NbBCII10-FGLA, SULFATE ION | Authors: | Vincke, C, Loris, R, Saerens, D, Martinez-Rodriguez, S, Muyldermans, S, Conrath, K. | Deposit date: | 2008-08-26 | Release date: | 2008-12-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold. J.Biol.Chem., 2008
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3EBA
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![BU of 3eba by Molmil](/molmil-images/mine/3eba) | CAbHul6 FGLW mutant (humanized) in complex with human lysozyme | Descriptor: | CAbHul6, Lysozyme C, SULFATE ION | Authors: | Loris, R, Vincke, C, Saerens, D, Martinez-Rodriguez, S, Muyldermans, S, Conrath, K. | Deposit date: | 2008-08-27 | Release date: | 2008-12-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold J.Biol.Chem., 284, 2009
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1ZM7
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![BU of 1zm7 by Molmil](/molmil-images/mine/1zm7) | Crystal structure of D. melanogaster deoxyribonucleoside kinase mutant N64D in complex with dTTP | Descriptor: | Deoxynucleoside kinase, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE | Authors: | Welin, M, Skovgaard, T, Knecht, W, Berenstein, D, Munch-Petersen, B, Piskur, J, Eklund, H. | Deposit date: | 2005-05-10 | Release date: | 2005-05-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for the changed substrate specificity of Drosophila melanogaster deoxyribonucleoside kinase mutant N64D. Febs J., 272, 2005
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1ZMX
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![BU of 1zmx by Molmil](/molmil-images/mine/1zmx) | Crystal structure of D. melanogaster deoxyribonucleoside kinase N64D mutant in complex with thymidine | Descriptor: | Deoxynucleoside kinase, SULFATE ION, THYMIDINE | Authors: | Welin, M, Skovgaard, T, Knecht, W, Berenstein, D, Munch-Petersen, B, Piskur, J, Eklund, H. | Deposit date: | 2005-05-11 | Release date: | 2005-05-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for the changed substrate specificity of Drosophila melanogaster deoxyribonucleoside kinase mutant N64D. Febs J., 272, 2005
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2JZI
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![BU of 2jzi by Molmil](/molmil-images/mine/2jzi) | |
1CXR
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![BU of 1cxr by Molmil](/molmil-images/mine/1cxr) | |
1KFZ
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![BU of 1kfz by Molmil](/molmil-images/mine/1kfz) | Solution Structure of C-terminal Sem-5 SH3 Domain (Ensemble of 16 Structures) | Descriptor: | SEX MUSCLE ABNORMAL PROTEIN 5 | Authors: | Ferreon, J.C, Volk, D.E, Luxon, B.A, Gorenstein, D, Hilser, V.J. | Deposit date: | 2001-11-24 | Release date: | 2003-05-20 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution Structure, Dynamics and Thermodynamics of the Native State Ensemble
of Sem-5 C-Terminal SH3 Domain Biochemistry, 42, 2003
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1J3G
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![BU of 1j3g by Molmil](/molmil-images/mine/1j3g) | Solution structure of Citrobacter Freundii AmpD | Descriptor: | AmpD protein, ZINC ION | Authors: | Liepinsh, E, Genereux, C, Dehareng, D, Joris, B, Otting, G. | Deposit date: | 2003-01-31 | Release date: | 2003-02-18 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | NMR Structure of Citrobacter freundii AmpD, Comparison with Bacteriophage T7 Lysozyme
and Homology with PGRP Domains J.Mol.Biol., 327, 2003
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7V8N
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![BU of 7v8n by Molmil](/molmil-images/mine/7v8n) | |
1C54
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![BU of 1c54 by Molmil](/molmil-images/mine/1c54) | SOLUTION STRUCTURE OF RIBONUCLEASE SA | Descriptor: | RIBONUCLEASE SA | Authors: | Laurents, D.V, Canadillas-Perez, J.M, Santoro, J, Schell, D, Pace, C.N, Rico, M, Bruix, M. | Deposit date: | 1999-10-22 | Release date: | 2001-11-28 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure and dynamics of ribonuclease Sa. Proteins, 44, 2001
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2L4V
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2M0J
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![BU of 2m0j by Molmil](/molmil-images/mine/2m0j) | |
2M0K
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![BU of 2m0k by Molmil](/molmil-images/mine/2m0k) | |
1BCG
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![BU of 1bcg by Molmil](/molmil-images/mine/1bcg) | SCORPION TOXIN BJXTR-IT | Descriptor: | TOXIN BJXTR-IT | Authors: | Oren, D, Froy, O, Amit, E, Kleinberger-Doron, N, Gurevitz, M, Shaanan, B. | Deposit date: | 1998-04-29 | Release date: | 1998-11-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | An excitatory scorpion toxin with a distinctive feature: an additional alpha helix at the C terminus and its implications for interaction with insect sodium channels. Structure, 6, 1998
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5K4I
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![BU of 5k4i by Molmil](/molmil-images/mine/5k4i) | Crystal Structure of ERK2 in complex with compound 22 | Descriptor: | 1,2-ETHANEDIOL, 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one, Mitogen-activated protein kinase 1 | Authors: | Yin, J, Wang, W. | Deposit date: | 2016-05-20 | Release date: | 2016-07-06 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development. J.Med.Chem., 59, 2016
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5K4J
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![BU of 5k4j by Molmil](/molmil-images/mine/5k4j) | Crystal Structure of CDK2 in complex with compound 22 | Descriptor: | 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one, Cyclin-dependent kinase 2 | Authors: | Yin, J, Wang, W. | Deposit date: | 2016-05-20 | Release date: | 2016-07-06 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development. J.Med.Chem., 59, 2016
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6NKO
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![BU of 6nko by Molmil](/molmil-images/mine/6nko) | Crystal structure of ForH | Descriptor: | ForH | Authors: | Zheng, J, Irani, S, Zhang, Y. | Deposit date: | 2019-01-07 | Release date: | 2019-04-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.403 Å) | Cite: | Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de Novo Purine Biosynthesis. J. Am. Chem. Soc., 141, 2019
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3SKC
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![BU of 3skc by Molmil](/molmil-images/mine/3skc) | |
4XJ0
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![BU of 4xj0 by Molmil](/molmil-images/mine/4xj0) | Crystal structure of ERK2 in complex with an inhibitor 14K | Descriptor: | 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]pyridin-2(1H)-one, Mitogen-activated protein kinase 1 | Authors: | Yin, J, Wang, W. | Deposit date: | 2015-01-08 | Release date: | 2015-09-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2. J.Med.Chem., 58, 2015
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7DE7
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![BU of 7de7 by Molmil](/molmil-images/mine/7de7) | Crystal structure of PDZD7 HHD domain | Descriptor: | (2R)-2-{[(2R)-2-{[(2S)-2-{[(2R)-2-hydroxypropyl]oxy}propyl]oxy}propyl]oxy}propan-1-ol, PDZ domain-containing protein 7 | Authors: | Wang, H, Lin, L, Lu, Q. | Deposit date: | 2020-11-02 | Release date: | 2021-08-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Structure and Membrane Targeting of the PDZD7 Harmonin Homology Domain (HHD) Associated With Hearing Loss. Front Cell Dev Biol, 9, 2021
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