1BCG

SCORPION TOXIN BJXTR-IT

Summary for 1BCG

• Entry DOI: 10.2210/pdb1bcg/pdb
• Descriptor: TOXIN BJXTR-IT (2 entities in total)
• Functional Keywords: excitatory neurotoxin
• Biological source: Hottentotta judaicus
• Cellular location: Secreted: P56637
• Total number of polymer chains: 1
• Total formula weight: 8597.83

Authors

Oren, D.,Froy, O.,Amit, E.,Kleinberger-Doron, N.,Gurevitz, M.,Shaanan, B. (deposition date: 1998-04-29, release date: 1998-11-18, Last modification date: 2024-10-30)

Primary citation

Oren, D.A.,Froy, O.,Amit, E.,Kleinberger-Doron, N.,Gurevitz, M.,Shaanan, B.
An excitatory scorpion toxin with a distinctive feature: an additional alpha helix at the C terminus and its implications for interaction with insect sodium channels.
Structure, 6:1095-1103, 1998

PubMed Abstract: Scorpion neurotoxins, which bind and modulate sodium channels, have been divided into two groups, the alpha and beta toxins, according to their activities. The beta-toxin class includes the groups of excitatory and depressant toxins, which differ in their mode of action and are highly specific against insects. The three-dimensional structures of several alpha and beta toxins have been determined at high resolution, but no detailed 3D structure of an excitatory toxin has been presented so far.

PubMed: 9753689
DOI: 10.1016/S0969-2126(98)00111-7

Experimental method

X-RAY DIFFRACTION (2.1 Å)