7RKY
| Binding mode of US27-Gi-scFv16 in OCL-state | Descriptor: | Antibody fragment scFv16, G-protein coupled receptor homolog US27, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Tsutsumi, N, Jude, K.M, Garcia, K.C. | Deposit date: | 2021-07-22 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7RKN
| Structure of CX3CL1-US28-Gi-scFv16 in OC-state | Descriptor: | Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ... | Authors: | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | Deposit date: | 2021-07-22 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7RKM
| Structure of CX3CL1-US28-Gi-scFv16 in C-state | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ... | Authors: | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | Deposit date: | 2021-07-22 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7RKX
| Structure of US27-Gi-scFv16 in CL-state | Descriptor: | Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Tsutsumi, N, Jude, K.M, Garcia, K.C. | Deposit date: | 2021-07-22 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7RAA
| Designed StabIL-2 seq15 | Descriptor: | Interleukin-2, MAGNESIUM ION | Authors: | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | Deposit date: | 2021-06-30 | Release date: | 2022-03-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RKF
| Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment scFv16, Fractalkine, ... | Authors: | Tsutsumi, N, Maeda, S, Qu, Q, Skiniotis, G, Kobilka, B.K, Garcia, K.C. | Deposit date: | 2021-07-22 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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3E2H
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3E3Q
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3EEB
| Structure of the V. cholerae RTX cysteine protease domain | Descriptor: | INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION | Authors: | Lupardus, P.J, Shen, A, Bogyo, M, Garcia, K.C. | Deposit date: | 2008-09-04 | Release date: | 2008-10-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain Science, 322, 2008
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3DUH
| Structure of Interleukin-23 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 subunit beta, Interleukin-23 subunit alpha | Authors: | Lupardus, P.J, Garcia, K.C. | Deposit date: | 2008-07-17 | Release date: | 2008-08-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. J.Mol.Biol., 382, 2008
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3E0G
| Structure of the Leukemia Inhibitory Factor Receptor (LIF-R) domains D1-D5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Leukemia inhibitory factor receptor, ... | Authors: | Lupardus, P.J, Garcia, K.C. | Deposit date: | 2008-07-31 | Release date: | 2008-09-23 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol.Cell, 31, 2008
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3GCD
| Structure of the V. cholerae RTX cysteine protease domain in complex with an aza-Leucine peptide inhibitor | Descriptor: | INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION, ... | Authors: | Lupardus, P.J, Garcia, K.C, Shen, A, Bogyo, M. | Deposit date: | 2009-02-21 | Release date: | 2009-05-26 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin. Nat.Chem.Biol., 5, 2009
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8CX4
| TCR-antigen complex AS8.4-YEIH-HLA*B27 | Descriptor: | AS8.4a, AS8.4b, Beta-2-microglobulin, ... | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-05-19 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
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8DH9
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8DH8
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8DHA
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8DA7
| Coevolved affibody-Z domain pair LL1.c6 | Descriptor: | Immunoglobulin G-binding protein A, MALONATE ION, affibody LL1.FIFV | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.02 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA8
| Coevolved affibody-Z domain pair LL2.c1 | Descriptor: | Affibody LL2.FIIK, GLYCEROL, Immunoglobulin G-binding protein A | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA9
| Coevolved affibody-Z domain pair LL2.c3 | Descriptor: | Affibody LL2.FIIV, GLYCEROL, Immunoglobulin G-binding protein A, ... | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DAC
| Coevolved affibody-Z domain pair LL2.c22 | Descriptor: | Affibody LL2.FILV, GLYCEROL, Immunoglobulin G-binding protein A | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA3
| Coevolved affibody-Z domain pair LL1.c1 | Descriptor: | Affibody LL1.FILF, Immunoglobulin G-binding protein A, MALONATE ION, ... | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA4
| Coevolved affibody-Z domain pair LL1.c2 | Descriptor: | Affibody LL1.FIVM, Immunoglobulin G-binding protein A, SULFATE ION, ... | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DAB
| Coevolved affibody-Z domain pair LL2.c17 | Descriptor: | Affibody LL2.IVVY, Immunoglobulin G-binding protein A | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.134 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA6
| Coevolved affibody-Z domain pair LL1.c5 | Descriptor: | Affibody LL1.FIIM, Immunoglobulin G-binding protein A | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA5
| Coevolved affibody-Z domain pair LL1.c4 | Descriptor: | GLYCEROL, Immunoglobulin G-binding protein A, affibody LL1.FIVM | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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