7D4P
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![BU of 7d4p by Molmil](/molmil-images/mine/7d4p) | Structure of human TRPC5 in complex with clemizole | Descriptor: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole, ... | Authors: | Chen, L, Song, K, Wei, M, Guo, W. | Deposit date: | 2020-09-24 | Release date: | 2021-03-31 | Last modified: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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7D4Q
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![BU of 7d4q by Molmil](/molmil-images/mine/7d4q) | Structure of human TRPC5 in complex with HC-070 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione, CALCIUM ION, ... | Authors: | Chen, L, Song, K, Wei, M, Guo, W. | Deposit date: | 2020-09-24 | Release date: | 2021-03-31 | Last modified: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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7D3F
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![BU of 7d3f by Molmil](/molmil-images/mine/7d3f) | Cryo-EM structure of human DUOX1-DUOXA1 in high-calcium state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Dual oxidase 1, ... | Authors: | Chen, L, Wu, J.X. | Deposit date: | 2020-09-19 | Release date: | 2020-12-09 | Last modified: | 2021-06-23 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Structures of human dual oxidase 1 complex in low-calcium and high-calcium states. Nat Commun, 12, 2021
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7D9R
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![BU of 7d9r by Molmil](/molmil-images/mine/7d9r) | Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9U
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![BU of 7d9u by Molmil](/molmil-images/mine/7d9u) | Structure of human soluble guanylate cyclase in the cinciguat-bound activated state | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9S
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![BU of 7d9s by Molmil](/molmil-images/mine/7d9s) | Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9T
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![BU of 7d9t by Molmil](/molmil-images/mine/7d9t) | Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1 | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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3BWH
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![BU of 3bwh by Molmil](/molmil-images/mine/3bwh) | Atomic resolution structure of cucurmosin, a novel type 1 RIP from the sarcocarp of Cucurbita moschata | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, beta-D-xylopyranose-(1-2)-[alpha-D-mannopyranose-(1-3)][alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, L. | Deposit date: | 2008-01-09 | Release date: | 2008-10-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Atomic resolution structure of cucurmosin, a novel type 1 ribosome-inactivating protein from the sarcocarp of Cucurbita moschata. J.Struct.Biol., 164, 2008
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8X2L
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![BU of 8x2l by Molmil](/molmil-images/mine/8x2l) | |
8WEJ
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![BU of 8wej by Molmil](/molmil-images/mine/8wej) | |
3WMC
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![BU of 3wmc by Molmil](/molmil-images/mine/3wmc) | Crystal structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with naphthalimide derivative Q2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(dimethylamino)-2-(2-{[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]amino}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione, Beta-hexosaminidase | Authors: | Chen, L, Zhou, Y, Chen, L, Yang, Q. | Deposit date: | 2013-11-16 | Release date: | 2014-11-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.095 Å) | Cite: | A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two beta-GlcNAcase homologs Sci Rep, 4, 2014
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2HJD
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![BU of 2hjd by Molmil](/molmil-images/mine/2hjd) | |
1RHP
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![BU of 1rhp by Molmil](/molmil-images/mine/1rhp) | |
1TQE
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![BU of 1tqe by Molmil](/molmil-images/mine/1tqe) | Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2 | Descriptor: | Histone deacetylase 9, MEF2 binding site of nur77 promoter, Myocyte-specific enhancer factor 2B | Authors: | Chen, L, Han, A, He, J, Wu, Y, Liu, J.O. | Deposit date: | 2004-06-17 | Release date: | 2004-12-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanism of Recruitment of Class II Histone Deacetylases by Myocyte Enhancer Factor-2. J.Mol.Biol., 345, 2005
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6WC5
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![BU of 6wc5 by Molmil](/molmil-images/mine/6wc5) | Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex | Descriptor: | Homeobox protein Nkx-2.5, Myocardin enhancer DNA, Myocyte-specific enhancer factor 2B | Authors: | Chen, L, Lei, X. | Deposit date: | 2020-03-29 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J.Mol.Biol., 432, 2020
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1AAN
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![BU of 1aan by Molmil](/molmil-images/mine/1aan) | CRYSTAL STRUCTURE ANALYSIS OF AMICYANIN AND APOAMICYANIN FROM PARACOCCUS DENITRIFICANS AT 2.0 ANGSTROMS AND 1.8 ANGSTROMS RESOLUTION | Descriptor: | AMICYANIN, COPPER (II) ION | Authors: | Chen, L, Durley, R.C.E, Lim, L.W, Mathews, F.S. | Deposit date: | 1992-04-09 | Release date: | 1993-10-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure analysis of amicyanin and apoamicyanin from Paracoccus denitrificans at 2.0 A and 1.8 A resolution. Protein Sci., 2, 1993
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4U1W
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![BU of 4u1w by Molmil](/molmil-images/mine/4u1w) | Full length GluA2-kainate-(R,R)-2b complex crystal form A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, ... | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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4U1X
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![BU of 4u1x by Molmil](/molmil-images/mine/4u1x) | Full length GluA2-kainate-(R,R)-2b complex crystal form B | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, ... | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.301 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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4U1Y
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![BU of 4u1y by Molmil](/molmil-images/mine/4u1y) | Full length GluA2-FW-(R,R)-2b complex | Descriptor: | 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2, ... | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.8999 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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4U1O
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![BU of 4u1o by Molmil](/molmil-images/mine/4u1o) | GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form C | Descriptor: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-15 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8501 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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4U1Z
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![BU of 4u1z by Molmil](/molmil-images/mine/4u1z) | GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form D | Descriptor: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2,Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9401 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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4U21
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![BU of 4u21 by Molmil](/molmil-images/mine/4u21) | GluA2flip sLBD complexed with FW and (R,R)-2b crystal form E | Descriptor: | 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2,Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.3908 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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4U22
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![BU of 4u22 by Molmil](/molmil-images/mine/4u22) | GluA2flip sLBD complexed with FW and (R,R)-2b crystal form D | Descriptor: | 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4409 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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4U23
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![BU of 4u23 by Molmil](/molmil-images/mine/4u23) | GluA2flip sLBD complexed with FW and (R,R)-2b crystal form F | Descriptor: | 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2,Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6734 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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2LOZ
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![BU of 2loz by Molmil](/molmil-images/mine/2loz) | The novel binding mode of DLC1 and Tensin2 PTB domain | Descriptor: | Rho GTPase-activating protein 7, Tensin-like C1 domain-containing phosphatase | Authors: | Liu, C, Chen, L, Zhu, G. | Deposit date: | 2012-01-29 | Release date: | 2012-06-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode. J.Biol.Chem., 287, 2012
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