1XI4
 
 | | Clathrin D6 Coat | | Descriptor: | Clathrin heavy chain, Clathrin light chain A | | Authors: | Fotin, A, Cheng, Y, Sliz, P, Grigorieff, N, Harrison, S.C, Kirchhausen, T, Walz, T. | | Deposit date: | 2004-09-21 | | Release date: | 2004-11-02 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (7.9 Å) | | Cite: | Molecular model for a complete clathrin lattice from electron cryomicroscopy
Nature, 432, 2004
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1XI5
 | | Clathrin D6 coat with auxilin J-domain | | Descriptor: | Auxilin J-domain, Clathrin heavy chain | | Authors: | Fotin, A, Cheng, Y, Grigorieff, N, Walz, T, Harrison, S.C, Kirchhausen, T. | | Deposit date: | 2004-09-21 | | Release date: | 2004-11-02 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (12 Å) | | Cite: | Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating
Nature, 432, 2004
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7STQ
 | | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase W574L mutant in complex with chlorimuron-ethyl | | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[[[(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)AMINO]CARBONYL]AMINO]SULFONYL]BENZOIC ACID ETHYL ESTER, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, ... | | Authors: | Guddat, L.W, Cheng, Y. | | Deposit date: | 2021-11-15 | | Release date: | 2022-06-01 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural basis of resistance to herbicides that target acetohydroxyacid synthase.
Nat Commun, 13, 2022
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9EEA
 | | GPCR A family receptor | | Descriptor: | ADENOSINE, Adenosine receptor A2a, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Bi, M, Wang, X, Ye, L, Cheng, Y. | | Deposit date: | 2024-11-18 | | Release date: | 2025-04-09 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Structure and function of a near fully-activated intermediate GPCR-G alpha beta gamma complex.
Nat Commun, 16, 2025
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9EE9
 | | GPCR A family receptor | | Descriptor: | ADENOSINE, Adenosine receptor A2a, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Bi, M, Wang, X, Ye, L, Cheng, Y. | | Deposit date: | 2024-11-18 | | Release date: | 2025-04-09 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Structure and function of a near fully-activated intermediate GPCR-G alpha beta gamma complex.
Nat Commun, 16, 2025
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9EE8
 | | GPCR A family receptor | | Descriptor: | ADENOSINE, Adenosine receptor A2a, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Bi, M, Wang, X, Ye, L, Cheng, Y. | | Deposit date: | 2024-11-18 | | Release date: | 2025-04-09 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (2.63 Å) | | Cite: | Structure and function of a near fully-activated intermediate GPCR-G alpha beta gamma complex.
Nat Commun, 16, 2025
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8CXO
 | | Cryo-EM structure of the unliganded mSMO-PGS2 in a lipidic environment | | Descriptor: | CHOLESTEROL, Smoothened homolog, GlgA glycogen synthase chimera | | Authors: | Zhang, K, Wu, H, Hoppe, N, Manglik, A, Cheng, Y. | | Deposit date: | 2022-05-22 | | Release date: | 2022-08-03 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Fusion protein strategies for cryo-EM study of G protein-coupled receptors.
Nat Commun, 13, 2022
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7U1U
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7U1D
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7U25
 | | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase W574L mutant in complex with bispyribac-sodium | | Descriptor: | 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, ... | | Authors: | Guddat, L.W, Cheng, Y. | | Deposit date: | 2022-02-23 | | Release date: | 2022-06-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | Structural basis of resistance to herbicides that target acetohydroxyacid synthase.
Nat Commun, 13, 2022
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7TZZ
 | | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase P197T mutant in complex with bispyribac-sodium | | Descriptor: | 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid, 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | | Authors: | Guddat, L.W, Cheng, Y. | | Deposit date: | 2022-02-16 | | Release date: | 2022-06-01 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Structural basis of resistance to herbicides that target acetohydroxyacid synthase.
Nat Commun, 13, 2022
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6UTG
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7T9I
 | | Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain, ... | | Authors: | Faust, B, Cheng, Y, Manglik, A. | | Deposit date: | 2021-12-19 | | Release date: | 2022-08-03 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
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7T9N
 | | M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure) | | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Faust, B, Cheng, Y, Manglik, A. | | Deposit date: | 2021-12-19 | | Release date: | 2022-08-03 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
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7T9M
 | | Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CS-17 Heavy Chain, ... | | Authors: | Faust, B, Cheng, Y, Manglik, A. | | Deposit date: | 2021-12-19 | | Release date: | 2022-08-10 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
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1Q57
 | | The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7 | | Descriptor: | DNA primase/helicase | | Authors: | Toth, E.A, Li, Y, Sawaya, M.R, Cheng, Y, Ellenberger, T. | | Deposit date: | 2003-08-06 | | Release date: | 2003-11-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.45 Å) | | Cite: | The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7
Mol.Cell, 12, 2003
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6D80
 | | Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri bound to saposin | | Descriptor: | CALCIUM ION, Mitochondrial calcium uniporter, Saposin A | | Authors: | Nguyen, N.X, Armache, J.-P, Cheng, Y, Bai, X.C. | | Deposit date: | 2018-04-25 | | Release date: | 2018-07-11 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | Cryo-EM structure of a fungal mitochondrial calcium uniporter.
Nature, 559, 2018
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6O72
 | | Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, TC-I 2014-bound state | | Descriptor: | (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Diver, M.M, Cheng, Y, Julius, D. | | Deposit date: | 2019-03-07 | | Release date: | 2019-09-18 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into TRPM8 inhibition and desensitization.
Science, 365, 2019
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8URJ
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6O77
 | | Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, calcium-bound state | | Descriptor: | CALCIUM ION, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | | Authors: | Diver, M.M, Cheng, Y, Julius, D. | | Deposit date: | 2019-03-07 | | Release date: | 2019-09-18 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into TRPM8 inhibition and desensitization.
Science, 365, 2019
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6O6A
 | | Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, ligand-free state | | Descriptor: | CHOLESTEROL HEMISUCCINATE, SODIUM ION, Transient receptor potential cation channel subfamily M member 8 | | Authors: | Diver, M.M, Cheng, Y, Julius, D. | | Deposit date: | 2019-03-05 | | Release date: | 2019-09-18 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural insights into TRPM8 inhibition and desensitization.
Science, 365, 2019
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6D7W
 | | Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri at 3.8 Angstrom resolution | | Descriptor: | CALCIUM ION, Mitochondrial calcium uniporter | | Authors: | Nguyen, N.X, Armache, J.-P, Cheng, Y, Bai, X.C. | | Deposit date: | 2018-04-25 | | Release date: | 2018-07-11 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-EM structure of a fungal mitochondrial calcium uniporter.
Nature, 559, 2018
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4JZA
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4KWE
 | | GDP-bound, double-stranded, curved FtsZ protofilament structure | | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Li, Y, Hsin, J, Zhao, L, Cheng, Y, Shang, W, Huang, K.C, Wang, H.W, Ye, S. | | Deposit date: | 2013-05-23 | | Release date: | 2013-07-31 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation
Science, 341, 2013
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6MG8
 | | Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched | | Descriptor: | CHOLESTEROL, Protein patched homolog 1 | | Authors: | Zhang, Y, Bulkley, D, Xin, Y, Roberts, K.J, Asarnow, D.E, Sharma, A, Myers, B.R, Cho, W, Cheng, Y, Beachy, P.A. | | Deposit date: | 2018-09-13 | | Release date: | 2018-11-28 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Cell, 175, 2018
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