7LIQ
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7LIP
| X-ray structure of SPOP MATH domain (D140G) | Descriptor: | SULFATE ION, Speckle-type POZ protein | Authors: | Botuyan, M.V, Cui, G, Mer, G. | Deposit date: | 2021-01-27 | Release date: | 2021-04-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication. Sci Adv, 7, 2021
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1HV2
| SOLUTION STRUCTURE OF YEAST ELONGIN C IN COMPLEX WITH A VON HIPPEL-LINDAU PEPTIDE | Descriptor: | ELONGIN C, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR | Authors: | Botuyan, M.V, Mer, G, Yi, G.-S, Koth, C.M, Case, D.A, Edwards, A.M, Chazin, W.J, Arrowsmith, C.H. | Deposit date: | 2001-01-05 | Release date: | 2001-09-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide. J.Mol.Biol., 312, 2001
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8U14
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 2) | Descriptor: | DNA (146-MER), DNA (147-MER), E3 ubiquitin-protein ligase RNF168, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | Deposit date: | 2023-08-30 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8U13
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 1) | Descriptor: | DNA (146-MER), DNA (147-MER), E3 ubiquitin-protein ligase RNF168, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | Deposit date: | 2023-08-30 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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2FHD
| Crystal structure of Crb2 tandem tudor domains | Descriptor: | DNA repair protein rhp9/CRB2, PHOSPHATE ION | Authors: | Lee, J, Botuyan, M.V, Thompson, J.R, Mer, G. | Deposit date: | 2005-12-23 | Release date: | 2007-01-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell(Cambridge,Mass.), 127, 2006
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5UMV
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5VZM
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8UPF
| Cryo-EM structure of the human nucleosome core particle in complex with RNF168-UbcH5c | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | Deposit date: | 2023-10-22 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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5VF0
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5VEY
| Solution NMR structure of histone H2A-H2B mono-ubiquitylated at H2A Lys15 in complex with RNF169 (653-708) | Descriptor: | E3 ubiquitin-protein ligase RNF169, Histone H2B type 1-J,Histone H2A type 1-B/E, Polyubiquitin-B | Authors: | Hu, Q, Botuyan, M.V, Cui, G, Mer, G. | Deposit date: | 2017-04-06 | Release date: | 2017-05-17 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18. Mol. Cell, 66, 2017
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5VX7
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8TXV
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 1) | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | Deposit date: | 2023-08-24 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8TXX
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 3) | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | Deposit date: | 2023-08-24 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8TXW
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 2) | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | Deposit date: | 2023-08-24 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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2G3R
| Crystal Structure of 53BP1 tandem tudor domains at 1.2 A resolution | Descriptor: | SULFATE ION, Tumor suppressor p53-binding protein 1 | Authors: | Lee, J, Botuyan, M.V, Thompson, J.R, Mer, G. | Deposit date: | 2006-02-20 | Release date: | 2007-01-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair. Cell(Cambridge,Mass.), 127, 2006
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2ETX
| Crystal Structure of MDC1 Tandem BRCT Domains | Descriptor: | Mediator of DNA damage checkpoint protein 1 | Authors: | Wasielewski, E, Kim, Y, Joachimiak, A, Thompson, J.R, Mer, G. | Deposit date: | 2005-10-27 | Release date: | 2005-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex. J.Biol.Chem., 287, 2012
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3P8D
| Crystal structure of the second Tudor domain of human PHF20 (homodimer form) | Descriptor: | Medulloblastoma antigen MU-MB-50.72 | Authors: | Cui, G, Lee, J, Thompson, J.R, Botuyan, M.V, Mer, G. | Deposit date: | 2010-10-13 | Release date: | 2011-06-22 | Last modified: | 2012-09-26 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nat.Struct.Mol.Biol., 19, 2012
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3PD7
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5UMS
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8UQE
| Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 26-residue linker (RING not modeled in density) | Descriptor: | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E | Authors: | Hu, Q, Botuyan, M.V, Mer, G. | Deposit date: | 2023-10-23 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.562 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQA
| Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 12-residue linker | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, SODIUM ION, ... | Authors: | Hu, Q, Botuyan, M.V, Mer, G. | Deposit date: | 2023-10-23 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.049 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQB
| Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 1) | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION | Authors: | Hu, Q, Botuyan, M.V, Mer, G. | Deposit date: | 2023-10-23 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.484 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQ9
| Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 4-residue linker | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, GLYCEROL, ... | Authors: | Hu, Q, Botuyan, M.V, Mer, G. | Deposit date: | 2023-10-23 | Release date: | 2024-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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5VWE
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