6IWT
 
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6JRX
 | | EGFR T790M/C797S in complex with compound 6i | | Descriptor: | Epidermal growth factor receptor, N-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]cyclohexyl}propanamide | | Authors: | Zhu, S.J, Yun, C.H. | | Deposit date: | 2019-04-06 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.201 Å) | | Cite: | Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.
J.Med.Chem., 63, 2020
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8I4Z
 | | CalA3 with hydrolysis product | | Descriptor: | 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, Beta-ketoacyl-acyl-carrier-protein synthase I | | Authors: | Wang, J, Wang, Z. | | Deposit date: | 2023-01-21 | | Release date: | 2023-02-22 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.97 Å) | | Cite: | C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
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8I4Y
 | | CalA3 complex structure with amidation product | | Descriptor: | 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, 3-HYDROXYANTHRANILIC ACID, Beta-ketoacyl-acyl-carrier-protein synthase I | | Authors: | Wang, J, Wang, Z. | | Deposit date: | 2023-01-21 | | Release date: | 2023-02-22 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
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6IIJ
 | | Cryo-EM structure of CV-A10 mature virion | | Descriptor: | SPHINGOSINE, VP1, VP2, ... | | Authors: | Chen, J.H, Ye, X.H, Cong, Y, Huang, Z. | | Deposit date: | 2018-10-06 | | Release date: | 2018-11-07 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses.
Cell Discov, 5, 2019
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2YNK
 | | Wzi, an Outer Membrane Protein Involved in Group 1 Capsule Assembly in Escherichia coli, is a Carbohydrate Binding Beta-Barrel | | Descriptor: | DODECANE, HEXANE, N-OCTANE, ... | | Authors: | Bushell, S.R, Mainprize, I.L, Wear, M.A, Lou, H, Kong, L, Davis, B, Bayley, H, Whitfield, C, Naismith, J.H. | | Deposit date: | 2012-10-16 | | Release date: | 2013-05-15 | | Last modified: | 2013-05-29 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Wzi is an Outer Membrane Lectin that Underpins Group 1 Capsule Assembly in Escherichia Coli.
Structure, 21, 2013
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5Y36
 | | Cryo-EM structure of SpCas9-sgRNA-DNA ternary complex | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, complementary DNA strand, ... | | Authors: | Huang, Q, Li, G, Huai, C. | | Deposit date: | 2017-07-27 | | Release date: | 2017-12-06 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (5.2 Å) | | Cite: | Structural insights into DNA cleavage activation of CRISPR-Cas9 system
Nat Commun, 8, 2017
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5UY3
 | | Crystal structure of human Fab PGT144, a broadly reactive and potent HIV-1 neutralizing antibody | | Descriptor: | Antibody PGT144 Fab heavy chain, Antibody PGT144 Fab light chain | | Authors: | Julien, J.-P, Lee, J.H, Wilson, I.A. | | Deposit date: | 2017-02-23 | | Release date: | 2017-04-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.
Immunity, 46, 2017
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5V8M
 | | BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibody 3BNC117 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Lee, J.H, Cottrell, C.A, Ward, A.B. | | Deposit date: | 2017-03-22 | | Release date: | 2017-05-03 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.
Immunity, 46, 2017
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7EN2
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7EMY
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7EN1
 | | Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module-after-condensation | | Descriptor: | (4S)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid, 2-HYDROXYBENZOIC ACID, 4'-PHOSPHOPANTETHEINE, ... | | Authors: | Wang, J.L, Wang, Z.J. | | Deposit date: | 2021-04-15 | | Release date: | 2021-12-22 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain.
Nat Commun, 13, 2022
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5V8L
 | | BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC117 antibody, ... | | Authors: | Lee, J.H, Ward, A.B. | | Deposit date: | 2017-03-22 | | Release date: | 2017-05-03 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.
Immunity, 46, 2017
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7CPX
 | | Lovastatin nonaketide synthase | | Descriptor: | Lovastatin nonaketide synthase, polyketide synthase component, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Wang, J, Wang, Z. | | Deposit date: | 2020-08-08 | | Release date: | 2021-01-13 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Structural basis for the biosynthesis of lovastatin.
Nat Commun, 12, 2021
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7CPY
 | | Lovastatin nonaketide synthase with LovC | | Descriptor: | Lovastatin nonaketide synthase, enoyl reductase component lovC, polyketide synthase component, ... | | Authors: | Wang, J, Wang, Z. | | Deposit date: | 2020-08-08 | | Release date: | 2021-01-13 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis for the biosynthesis of lovastatin.
Nat Commun, 12, 2021
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5WVI
 | | The resting state of yeast proteasome | | Descriptor: | 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... | | Authors: | Ding, Z, Cong, Y. | | Deposit date: | 2016-12-25 | | Release date: | 2017-03-22 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (6.3 Å) | | Cite: | High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx
Cell Res., 27, 2017
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8J4T
 | | GajA-GajB complex | | Descriptor: | Endonuclease GajA, Gabija protein GajB | | Authors: | Wei, T, Ma, J, Huo, Y. | | Deposit date: | 2023-04-20 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural and biochemical insights into the mechanism of the Gabija bacterial immunity system.
Nat Commun, 15, 2024
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7DK3
 | | SARS-CoV-2 S trimer, S-open | | Descriptor: | Spike glycoprotein | | Authors: | Xu, C, Cong, Y. | | Deposit date: | 2020-11-23 | | Release date: | 2020-12-16 | | Last modified: | 2021-02-17 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.
Sci Adv, 7, 2021
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7DD2
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7DK4
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7DDN
 | | SARS-Cov2 S protein at open state | | Descriptor: | Spike glycoprotein | | Authors: | Cong, Y, Liu, C.X. | | Deposit date: | 2020-10-29 | | Release date: | 2020-11-25 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (6.3 Å) | | Cite: | Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections.
Nat Commun, 12, 2021
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7DF4
 | | SARS-CoV-2 S-ACE2 complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | | Authors: | Cong, X, Yao, C. | | Deposit date: | 2020-11-06 | | Release date: | 2020-12-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.
Sci Adv, 7, 2021
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7DDD
 | | SARS-Cov2 S protein at close state | | Descriptor: | Spike glycoprotein | | Authors: | Cong, Y, Liu, C.X. | | Deposit date: | 2020-10-28 | | Release date: | 2020-11-25 | | Last modified: | 2021-01-27 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections.
Nat Commun, 12, 2021
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7DF3
 | | SARS-CoV-2 S trimer, S-closed | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Cong, X, Yao, C. | | Deposit date: | 2020-11-06 | | Release date: | 2020-12-16 | | Last modified: | 2021-02-17 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.
Sci Adv, 7, 2021
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7DCX
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