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3PGG
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BU of 3pgg by Molmil
Crystal structure of cryptosporidium parvum u6 snrna-associated sm-like protein lsm5
Descriptor: U6 snRNA-associated Sm-like protein LSm5. SM domain
Authors:Dong, A, Gao, M, Zhao, Y, Lew, J, Wasney, G.A, Kozieradzki, I, Vedadi, M, Edwards, A, Arrowsmith, C, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Artz, J, Structural Genomics Consortium (SGC)
Deposit date:2010-11-01
Release date:2011-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Genome-Scale Protein Expression and Structural Biology of Plasmodium Falciparum and Related Apicomplexan Organisms.
Mol.Biochem.Parasitol., 151, 2007
4JLG
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BU of 4jlg by Molmil
SETD7 in complex with inhibitor (R)-PFI-2 and S-adenosyl-methionine
Descriptor: 8-fluoro-N-{(2R)-1-oxo-1-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]propan-2-yl}-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, ...
Authors:Dong, A, Wu, H, Zeng, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2013-03-12
Release date:2013-04-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.896 Å)
Cite:(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Proc.Natl.Acad.Sci.USA, 111, 2014
3RJW
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BU of 3rjw by Molmil
Crystal structure of histone lysine methyltransferase g9a with an inhibitor
Descriptor: 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)piperidin-4-yl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Dong, A, Wasney, G.A, Tempel, W, Liu, F, Barsyte, D, Allali-Hassani, A, Chen, X, Chau, I, Hajian, T, Senisterra, G, Chavda, N, Arora, K, Siarheyeva, A, Kireev, D.B, Herold, J.M, Bochkarev, A, Bountra, C, Weigelt, J, Edwards, A.M, Frye, S.V, Arrowsmith, C.H, Brown, P.J, Jin, J, Vedadi, M, Structural Genomics Consortium (SGC)
Deposit date:2011-04-15
Release date:2011-05-04
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
Nat.Chem.Biol., 7, 2011
1ZD1
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BU of 1zd1 by Molmil
Human Sulfortransferase SULT4A1
Descriptor: GLYCEROL, Sulfotransferase 4A1
Authors:Dong, A, Dombrovski, L, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Sundstrom, M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:2005-04-13
Release date:2005-04-26
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural and chemical profiling of the human cytosolic sulfotransferases.
Plos Biol., 5, 2007
5TTF
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BU of 5ttf by Molmil
Crystal structure of catalytic domain of G9a with MS012
Descriptor: CHLORIDE ION, Histone-lysine N-methyltransferase EHMT2, N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine, ...
Authors:DONG, A, ZENG, H, LIU, J, XIONG, Y, BABAULT, N, JIN, J, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, WU, H, BROWN, P.J, Structural Genomics Consortium (SGC)
Deposit date:2016-11-03
Release date:2016-12-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017
5UBA
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BU of 5uba by Molmil
Human RNA Pseudouridylate Synthase Domain Containing 4
Descriptor: CALCIUM ION, CHLORIDE ION, RNA pseudouridylate synthase domain-containing protein 4, ...
Authors:DONG, A, ZENG, H, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:2016-12-20
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:The Crystal Structure of Human Pseudouridylate Synthase Domain Containing 4. To be published
to be published
5TTG
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BU of 5ttg by Molmil
Crystal structure of catalytic domain of GLP with MS012
Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:DONG, A, ZENG, H, LIU, J, XIONG, Y, BABAULT, N, JIN, J, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, WU, H, BROWN, P.J, Structural Genomics Consortium (SGC)
Deposit date:2016-11-03
Release date:2017-02-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017
4YWQ
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BU of 4ywq by Molmil
Crystal structure of the ROQ domain of human Roquin-1
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Dong, A, Zhang, Q, Li, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2015-03-20
Release date:2015-04-22
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the ROQ domain of human Roquin-1
To be Published
4YVD
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BU of 4yvd by Molmil
Crytsal structure of human Pleiotropic Regulator 1 (PRL1)
Descriptor: CHLORIDE ION, Pleiotropic regulator 1, SODIUM ION, ...
Authors:Dong, A, Zeng, H, Xu, C, Tempel, W, Li, Y, He, H, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2015-03-19
Release date:2015-04-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crytsal structure of human Pleiotropic Regulator 1 (PRL1).
to be published
4Z31
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BU of 4z31 by Molmil
Crystal structure of the RC3H2 ROQ domain in complex with stem-loop and double-stranded forms of RNA
Descriptor: CHLORIDE ION, RNA (5'-R(*A)-D(P*UP*GP*UP*UP*CP*UP*GP*UP*GP*AP*AP*CP*AP*C)-3'), Roquin-2, ...
Authors:DONG, A, ZHANG, Q, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC)
Deposit date:2015-03-30
Release date:2015-10-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Sci Rep, 5, 2015
4Z30
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BU of 4z30 by Molmil
Crystal structure of the ROQ domain of human Roquin-2
Descriptor: Roquin-2, UNKNOWN ATOM OR ION
Authors:DONG, A, ZHANG, Q, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC)
Deposit date:2015-03-30
Release date:2015-10-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Sci Rep, 5, 2015
4IIM
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BU of 4iim by Molmil
Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide
Descriptor: Intersectin-1, UNKNOWN ATOM OR ION, peptide ligand
Authors:Dong, A, Guan, X, Huang, H, Wernimont, A, Gu, J, Sidhu, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2012-12-20
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide
To be Published
2FBN
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BU of 2fbn by Molmil
Plasmodium falciparum putative FK506-binding protein PFL2275c, C-terminal TPR-containing domain
Descriptor: 70 kDa peptidylprolyl isomerase, putative
Authors:Dong, A, Lew, J, Koeieradzki, I, Sundararajan, E, Melone, M, Wasney, G, Zhao, Y, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Hills, T, Structural Genomics Consortium (SGC)
Deposit date:2005-12-09
Release date:2006-01-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide.
Protein Sci., 18, 2009
5H9M
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BU of 5h9m by Molmil
Crystal structure of siah2 SBD domain
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase SIAH2, PENTAETHYLENE GLYCOL, ...
Authors:Dong, A, Zhang, Q, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2015-12-28
Release date:2016-02-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.761 Å)
Cite:Crystal structure of siah2 SBD domain
to be published
6DVR
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BU of 6dvr by Molmil
Crystal structure of human CARM1 with (R)-SKI-72
Descriptor: (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name), 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Histone-arginine methyltransferase CARM1, ...
Authors:Dong, A, Zeng, H, Hutchinson, A, Seitova, A, Luo, M, Cai, X.C, Ke, W, Wang, J, Shi, C, Zheng, W, Lee, J.P, Ibanez, G, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2018-06-25
Release date:2018-07-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Crystal structure of human CARM1 with (R)-SKI-72
to be published
4JUY
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BU of 4juy by Molmil
Crystal structure of the PUB domain of E3 ubiquitin ligase RNF31
Descriptor: E3 ubiquitin-protein ligase RNF31, UNKNOWN ATOM OR ION
Authors:Dong, A, Hu, J, Li, Y, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2013-03-25
Release date:2013-04-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the PUB domain of E3 ubiquitin ligase RNF31
To be Published
5JJW
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BU of 5jjw by Molmil
Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain
Descriptor: 1,2-ETHANEDIOL, Squamous cell carcinoma antigen recognized by T-cells 3, UNKNOWN ATOM OR ION, ...
Authors:Dong, A, Zhang, Q, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2016-04-25
Release date:2016-05-04
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain
to be published
5JJX
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BU of 5jjx by Molmil
Crystal structure of the HAT domain of sart3
Descriptor: CHLORIDE ION, Squamous cell carcinoma antigen recognized by T-cells 3, UNKNOWN ATOM OR ION
Authors:DONG, A, ZHANG, Q, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC)
Deposit date:2016-04-25
Release date:2016-05-04
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the HAT domain of sart3
to be published
5JJZ
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BU of 5jjz by Molmil
Chromo domain of human Chromodomain Protein, Y-Like 2
Descriptor: Chromodomain Y-like protein 2, LYS-LYS-LYS-ALA-ARG-MLY-SER-ALA-GLY-ALA-ALA-LYS-TYR
Authors:DONG, A, DOMBROVSKI, L, LOPPNAU, P, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, MIN, J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:2016-04-25
Release date:2016-05-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of CDYL2 domain of human CDYL2 protein
to be published
3NUQ
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BU of 3nuq by Molmil
Structure of a putative nucleotide phosphatase from Saccharomyces cerevisiae
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Dong, A, Yang, C, Singer, A.U, Evdokimova, E, Kudritsdka, M, Brown, G, Edwards, A.M, Joachimiak, A, Savchenko, A, Yakunin, A.F, Midwest Center for Structural Genomics (MCSG)
Deposit date:2010-07-07
Release date:2010-08-18
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of a putative nucleotide phosphatase from Saccharomyces cerevisiae
To be Published
4IKP
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BU of 4ikp by Molmil
Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin
Descriptor: (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, Histone-arginine methyltransferase CARM1, ...
Authors:Dong, A, Dombrovski, L, He, H, Ibanez, G, Wernimont, A, Zheng, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2012-12-27
Release date:2013-02-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
Elife, 8, 2019
2A14
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BU of 2a14 by Molmil
Crystal Structure of Human Indolethylamine N-methyltransferase with SAH
Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, indolethylamine N-methyltransferase
Authors:Dong, A, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:2005-06-17
Release date:2005-06-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Human Indolethylamine N-methyltransferase in complex with SAH.
To be Published
2A5J
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BU of 2a5j by Molmil
Crystal Structure of Human RAB2B
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-2B
Authors:Dong, A, Wang, J, Shen, Y, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC)
Deposit date:2005-06-30
Release date:2005-07-19
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Crystal structure of human RAB2B
To be Published
4LEC
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BU of 4lec by Molmil
Human Methyltransferase-Like Protein 21A
Descriptor: Protein-lysine methyltransferase METTL21A, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION
Authors:Dong, A, Zeng, H, Fenner, M, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2013-06-25
Release date:2013-07-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:The Crystal Structure of Human Methyltransferase-Like Protein 21A in Complex with SAH
To be Published
6DK3
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BU of 6dk3 by Molmil
HUMAN MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASe 2
Descriptor: Serine hydroxymethyltransferase, mitochondrial, UNKNOWN ATOM OR ION
Authors:Dong, A, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:2018-05-28
Release date:2018-06-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:HUMAN MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASe 2
to be published

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