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5FVS
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BU of 5fvs by Molmil
Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl) ethyl)pyridin-2-amine
Descriptor: 4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVR
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BU of 5fvr by Molmil
Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-METHYL-6-(2-(5-(1-METHYLPIPERIDIN-4-YL)PYRIDIN-3-YL) ETHYL)PYRIDIN-2-AMINE
Descriptor: 4-methyl-6-(2-(5-(1-methylpiperidin-4-yl)pyridin-3-yl)ethyl)pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.842 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVX
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BU of 5fvx by Molmil
Structure of human nNOS R354A G357D mutant heme domain in complex with with 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL) PYRIDIN-3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE, NITRIC OXIDE SYNTHASE, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVO
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BU of 5fvo by Molmil
Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(2-(5-(3-methoxypropylamino)pyridin-3-yl)ethyl)-4- methylpyridin-2-amine
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-(5-(3-methoxypropylamino)pyridin-3-yl)ethyl)-4-methylpyridin-2-amine, NITRIC OXIDE SYNTHASE, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVU
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BU of 5fvu by Molmil
Structure of human nNOS R354A G357D mutant heme domain in complex with 4-methyl-6-(2-(5-(4-methylpiperazin-1-yl)pyridin-3-yl)ethyl) pyridin-2-amine
Descriptor: 1,2-ETHANEDIOL, 4-methyl-6-(2-(5-(4-methylpiperazin-1-yl)pyridin-3-yl)ethyl)pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.224 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVP
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BU of 5fvp by Molmil
Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-[2-(5-morpholin-4-ylpyridin-3-yl)ethyl]pyridin-2-amine
Descriptor: 4-methyl-6-[2-(5-morpholin-4-ylpyridin-3-yl)ethyl]pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVT
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BU of 5fvt by Molmil
Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(2-(5-(3-(dimethylamino)propyl)pyridin-3-yl)ethyl)-4- methylpyridin-2-amine
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.828 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FW0
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BU of 5fw0 by Molmil
Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(2-(5-((2-methoxyethyl)(methyl)amino)pyridin-3-yl) ethyl)-4-methylpyridin-2-amine
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-(5-((2-methoxyethyl)(methyl)amino)pyridin-3-yl)ethyl)-4-methylpyridin-2-amine, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVV
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BU of 5fvv by Molmil
Structure of human nNOS R354A G357D mutant heme domain in complex with 4-methyl-6-(2-(5-(1-methylpiperidin-4-yl)pyridin-3-yl)ethyl) pyridin-2-amine
Descriptor: 4-methyl-6-(2-(5-(1-methylpiperidin-4-yl)pyridin-3-yl)ethyl)pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, NITRIC OXIDE SYNTHASE, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVY
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BU of 5fvy by Molmil
Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(4-methylpiperazin-1-yl)pyridin-3-yl) ethyl)pyridin-2-amine
Descriptor: 1,2-ETHANEDIOL, 4-methyl-6-(2-(5-(4-methylpiperazin-1-yl)pyridin-3-yl)ethyl)pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
2QYN
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BU of 2qyn by Molmil
Crystal structure of PDE4D2 in complex with inhibitor NPV
Descriptor: 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, MAGNESIUM ION, ZINC ION, ...
Authors:Ke, H.
Deposit date:2007-08-15
Release date:2008-04-08
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J., 408, 2007
3B2R
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BU of 3b2r by Molmil
Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil
Descriptor: 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, cGMP-specific 3',5'-cyclic phosphodiesterase
Authors:Huanchen, W, Mengchun, Y, Howard, R, Sharron, H.F, Hengming, K.
Deposit date:2007-10-19
Release date:2008-05-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
Mol.Pharmacol., 73, 2008
5YQN
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BU of 5yqn by Molmil
Crystal structure of Sirt2 in complex with selective inhibitor L55
Descriptor: DI(HYDROXYETHYL)ETHER, N-[3-[[3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]phenyl]methoxy]phenyl]-1-methyl-pyrazole-4-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ...
Authors:Wang, H, Yu, Y, Li, G, Chen, Q.
Deposit date:2017-11-07
Release date:2018-10-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
6IWV
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BU of 6iwv by Molmil
Crystal structure of a single strand DNA binding protein
Descriptor: Single-stranded DNA-binding protein 2
Authors:Wang, H.Y, Yan, X.X.
Deposit date:2018-12-07
Release date:2019-08-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystal structure of the LUFS domain of human single-stranded DNA binding Protein 2 (SSBP2).
Protein Sci., 28, 2019
5YQO
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BU of 5yqo by Molmil
Crystal structure of Sirt2 in complex with selective inhibitor L5C
Descriptor: N-[4-[[3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]phenyl]methoxy]phenyl]-1-methyl-pyrazole-4-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION
Authors:Wang, H, Yu, Y, Li, G, Chen, Q.
Deposit date:2017-11-07
Release date:2018-10-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.483 Å)
Cite:X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
5YQL
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BU of 5yql by Molmil
Crystal structure of Sirt2 in complex with selective inhibitor A2I
Descriptor: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[3-(phenoxymethyl)phenyl]ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ...
Authors:Wang, H, Yu, Y, Li, G, Chen, Q.
Deposit date:2017-11-07
Release date:2018-10-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
5YQM
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BU of 5yqm by Molmil
Crystal structure of Sirt2 in complex with selective inhibitor A29
Descriptor: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-(4-phenylsulfanylphenyl)ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ...
Authors:Wang, H, Yu, Y, Li, G, chen, Q.
Deposit date:2017-11-07
Release date:2018-10-17
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.735 Å)
Cite:X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
3IWW
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BU of 3iww by Molmil
Crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DBIBzL, a urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Barinka, C, Lubkowski, J.
Deposit date:2009-09-03
Release date:2009-11-24
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies.
Bioorg.Med.Chem.Lett., 20, 2010
4ZDG
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BU of 4zdg by Molmil
Structure of the Adenovirus 14p1 knob domain
Descriptor: Fiber protein
Authors:Fender, P, Ducournau, C, Zubieta, C.
Deposit date:2015-04-17
Release date:2015-09-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Intracellular Signaling and Desmoglein 2 Shedding Triggered by Human Adenoviruses Ad3, Ad14, and Ad14P1.
J.Virol., 89, 2015
6EDU
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BU of 6edu by Molmil
B41 SOSIP.664 in complex with soluble CD4 (D1-D2), the co-receptor mimicking antibody 21c and the broadly neutralizing antibody 8ANC195
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 21c Fab VH domain, ...
Authors:Barnes, C.O, Bjorkman, P.J.
Deposit date:2018-08-11
Release date:2018-10-17
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (4.06 Å)
Cite:Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion.
Cell Host Microbe, 24, 2018
5YS1
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BU of 5ys1 by Molmil
Crystal structure of Multicopper Oxidase CueO G304K mutant
Descriptor: Blue copper oxidase CueO, COPPER (II) ION
Authors:Wang, H.Q, Liu, X.Q, Zhao, J.T, Yue, Q.X, Yan, Y.H, Dong, Y.H, Fan, Y.L, Tian, J, Wu, N.F, Gong, Y.
Deposit date:2017-11-12
Release date:2018-10-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity
Sci Rep, 8, 2018
5YS5
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BU of 5ys5 by Molmil
Crystal structure of Multicopper Oxidase CueO G304K mutant with seven copper ions
Descriptor: Blue copper oxidase CueO, COPPER (II) ION
Authors:Wang, H.Q, Liu, X.Q, Zhao, J.T, Yue, Q.X, Yan, Y.H, Dong, Y.H, Fan, Y.L, Tian, J, Wu, N.F, Gong, Y.
Deposit date:2017-11-13
Release date:2018-10-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity
Sci Rep, 8, 2018
6JBZ
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BU of 6jbz by Molmil
Structural analysis of molybdopterin synthases from two mycobacteria pathogens
Descriptor: MoaD/ThiS family protein, Molybdenum cofactor biosynthesis protein E, SULFATE ION
Authors:Wang, H.Y, Liu, X.
Deposit date:2019-01-27
Release date:2019-02-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Structural analysis of molybdopterin synthases from two mycobacterial pathogens.
Biochem. Biophys. Res. Commun., 511, 2019
8GK7
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BU of 8gk7 by Molmil
MsbA bound to cerastecin C
Descriptor: 2-[(4-butylbenzene-1-sulfonyl)amino]-5-[(3-{4-[(4-butylbenzene-1-sulfonyl)amino]-3-carboxyanilino}-3-oxopropyl)carbamoyl]benzoic acid, Lipid A export ATP-binding/permease protein MsbA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Chen, Y, Klein, D.
Deposit date:2023-03-17
Release date:2024-04-24
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii.
Nat Microbiol, 9, 2024
6JC0
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BU of 6jc0 by Molmil
Structural analysis of molybdopterin synthases from two mycobacteria pathogens
Descriptor: Putative molybdenum cofactor biosynthesis protein, Putative molybdenum cofactor biosynthesis protein D2 (MoaD2) / thiamine S
Authors:Liu, X, Wang, H.Y.
Deposit date:2019-01-27
Release date:2019-02-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of molybdopterin synthases from two mycobacterial pathogens.
Biochem. Biophys. Res. Commun., 511, 2019

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