5FVO

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(2-(5-(3-methoxypropylamino)pyridin-3-yl)ethyl)-4- methylpyridin-2-amine

Summary for 5FVO

Related5FVP 5FVQ 5FVR 5FVS 5FVT 5FVU 5FVV 5FVW 5FVX 5FVY 5FVZ 5FW0
DescriptorNITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
Functional Keywordsoxidoreductase, nitric oxide synthase, inhibitor complex
Biological sourceRATTUS NORVEGICUS (NORWAY RAT)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein  P29476
Total number of polymer chains1
Total molecular weight50036.07
Authors
Li, H.,Poulos, T.L. (deposition date: 2016-02-10, release date: 2016-04-20, Last modification date: 2016-06-08)
Primary citation
Wang, H.,Qin, Y.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59:4913-, 2016
PubMed: 27050842 (PDB entries with the same primary citation)
DOI: 10.1021/ACS.JMEDCHEM.6B00273
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.12 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25150.7%5.5%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report