7RHK
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![BU of 7rhk by Molmil](/molmil-images/mine/7rhk) | Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-trapped closed state | Descriptor: | (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, ... | Authors: | Xue, J, Han, Y, Jiang, Y. | Deposit date: | 2021-07-17 | Release date: | 2021-11-03 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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6LAN
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![BU of 6lan by Molmil](/molmil-images/mine/6lan) | Structure of CCDC50 and LC3B complex | Descriptor: | Coiled-coil domain-containing protein 50,Microtubule-associated proteins 1A/1B light chain 3B | Authors: | Liu, L, Li, J, Hou, P. | Deposit date: | 2019-11-12 | Release date: | 2020-09-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection. Cell Res., 31, 2021
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6GMS
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![BU of 6gms by Molmil](/molmil-images/mine/6gms) | Solution NMR structure of the major type IV pilin PpdD from enterohemorrhagic Escherichia coli (EHEC) | Descriptor: | Prepilin peptidase-dependent protein D | Authors: | Amorim, G.C, Bardiaux, B, Luna-Rico, A, Zeng, W, Guilvout, I, Egelman, E, Nilges, M, Francetic, O, Izadi-Pruneyre, N. | Deposit date: | 2018-05-28 | Release date: | 2019-05-15 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus. Structure, 27, 2019
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5I44
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![BU of 5i44 by Molmil](/molmil-images/mine/5i44) | Structure of RacA-DNA complex; P21 form | Descriptor: | Chromosome-anchoring protein RacA, DNA (5'-D(*TP*GP*AP*CP*GP*CP*CP*GP*GP*CP*GP*TP*CP*A)-3') | Authors: | Schumacher, M.A. | Deposit date: | 2016-02-11 | Release date: | 2016-05-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.621 Å) | Cite: | Molecular insights into DNA binding and anchoring by the Bacillus subtilis sporulation kinetochore-like RacA protein. Nucleic Acids Res., 44, 2016
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7N7P
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![BU of 7n7p by Molmil](/molmil-images/mine/7n7p) | Cryo-EM structure of human TMEM120A | Descriptor: | COENZYME A, Ion channel TACAN | Authors: | Xue, J, Han, Y, Jiang, Y. | Deposit date: | 2021-06-10 | Release date: | 2021-09-01 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase. Elife, 10, 2021
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6XPD
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![BU of 6xpd by Molmil](/molmil-images/mine/6xpd) | |
6XPF
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![BU of 6xpf by Molmil](/molmil-images/mine/6xpf) | Cryo-EM structure of human ZnT8 WT, in the absence of zinc, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation | Descriptor: | ZINC ION, Zinc transporter 8 | Authors: | Bai, X.C, Xue, J, Jiang, Y.X. | Deposit date: | 2020-07-08 | Release date: | 2020-08-05 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations. Elife, 9, 2020
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6XPE
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![BU of 6xpe by Molmil](/molmil-images/mine/6xpe) | Cryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing conformation | Descriptor: | ZINC ION, Zinc transporter 8 | Authors: | Bai, X.C, Xue, J, Jiang, Y.X. | Deposit date: | 2020-07-08 | Release date: | 2020-08-05 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations. Elife, 9, 2020
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5H6I
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![BU of 5h6i by Molmil](/molmil-images/mine/5h6i) | Crystal Structure of GBS CAMP Factor | Descriptor: | CHLORIDE ION, Protein B, SULFATE ION | Authors: | Jin, T.C, Brefo-Mensah, E.K. | Deposit date: | 2016-11-13 | Release date: | 2017-11-22 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of theStreptococcus agalactiaeCAMP factor provides insights into its membrane-permeabilizing activity. J.Biol.Chem., 293, 2018
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8EWG
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![BU of 8ewg by Molmil](/molmil-images/mine/8ewg) | Cryo-EM structure of a riboendonclease | Descriptor: | CRISPR-associated endonuclease Cas9, RNA (56-MER) | Authors: | Li, Z, Wang, F. | Deposit date: | 2022-10-23 | Release date: | 2023-08-30 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural Basis for the Ribonuclease Activity of a Thermostable CRISPR-Cas13a from Thermoclostridium caenicola. J.Mol.Biol., 435, 2023
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6U9X
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![BU of 6u9x by Molmil](/molmil-images/mine/6u9x) | Structure of T. brucei MERS1-RNA complex | Descriptor: | Mitochondrial edited mRNA stability factor 1, RNA (5'-R(*GP*AP*GP*AP*GP*GP*GP*GP*GP*UP*U)-3') | Authors: | Schumacher, M.A. | Deposit date: | 2019-09-09 | Release date: | 2019-11-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs inTrypanosoma brucei. Rna, 26, 2020
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7SQ7
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![BU of 7sq7 by Molmil](/molmil-images/mine/7sq7) | Cryo-EM structure of mouse PI(3,5)P2-bound TRPML1 channel at 2.41 Angstrom resolution | Descriptor: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, ... | Authors: | Gan, N, Han, Y, Jiang, Y. | Deposit date: | 2021-11-04 | Release date: | 2022-02-02 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (2.41 Å) | Cite: | Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7SQ8
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![BU of 7sq8 by Molmil](/molmil-images/mine/7sq8) | Cryo-EM structure of mouse apo TRPML1 channel at 2.598 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | Authors: | Gan, N, Han, Y, Jiang, Y. | Deposit date: | 2021-11-04 | Release date: | 2022-02-02 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (2.598 Å) | Cite: | Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7SQ9
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![BU of 7sq9 by Molmil](/molmil-images/mine/7sq9) | Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution | Descriptor: | (1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30S,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gan, N, Han, Y, Jiang, Y. | Deposit date: | 2021-11-04 | Release date: | 2022-02-02 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (2.11 Å) | Cite: | Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7SQ6
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![BU of 7sq6 by Molmil](/molmil-images/mine/7sq6) | Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1, ... | Authors: | Gan, N, Han, Y, Jiang, Y. | Deposit date: | 2021-11-04 | Release date: | 2022-02-02 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (2.32 Å) | Cite: | Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin. Proc.Natl.Acad.Sci.USA, 119, 2022
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3K03
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![BU of 3k03 by Molmil](/molmil-images/mine/3k03) | Crystal Structure of CNG mimicking NaK mutant, NaK-DTPP, K+ complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein NaK | Authors: | Jiang, Y, Derebe, M.G. | Deposit date: | 2009-09-24 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites. Proc.Natl.Acad.Sci.USA, 108, 2011
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3K04
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![BU of 3k04 by Molmil](/molmil-images/mine/3k04) | Crystal Structure of CNG mimicking NaK mutant, NaK-DTPP, Na+ complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein NaK, SODIUM ION | Authors: | Jiang, Y, Derebe, M.G. | Deposit date: | 2009-09-24 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. Proc.Natl.Acad.Sci.USA, 108, 2011
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3K0D
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![BU of 3k0d by Molmil](/molmil-images/mine/3k0d) | Crystal Structure of CNG mimicking NaK mutant, NaK-ETPP, K+ complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein NaK | Authors: | Jiang, Y, Derebe, M.G. | Deposit date: | 2009-09-24 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. Proc.Natl.Acad.Sci.USA, 108, 2011
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3K08
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![BU of 3k08 by Molmil](/molmil-images/mine/3k08) | Crystal Structure of CNG mimicking NaK mutant, NaK-NTPP, Na+ complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein NaK, SODIUM ION | Authors: | Jiang, Y, Derebe, M.G. | Deposit date: | 2009-09-24 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. Proc.Natl.Acad.Sci.USA, 108, 2011
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3K06
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![BU of 3k06 by Molmil](/molmil-images/mine/3k06) | Crystal Structure of CNG mimicking NaK mutant, NaK-NTPP, K+ complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein NaK | Authors: | Jiang, Y, Derebe, M.G. | Deposit date: | 2009-09-24 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. Proc.Natl.Acad.Sci.USA, 108, 2011
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3K0G
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![BU of 3k0g by Molmil](/molmil-images/mine/3k0g) | Crystal Structure of CNG mimicking NaK mutant, NaK-ETPP, Na+ complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein NaK, SODIUM ION | Authors: | Jiang, Y, Derebe, M.G. | Deposit date: | 2009-09-24 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. Proc.Natl.Acad.Sci.USA, 108, 2011
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5HWY
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![BU of 5hwy by Molmil](/molmil-images/mine/5hwy) | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 10 mM Na+ and zero Ca2+ | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ACETATE ION, PENTADECANE, ... | Authors: | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | Deposit date: | 2016-01-29 | Release date: | 2016-05-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.098 Å) | Cite: | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger Nat.Struct.Mol.Biol., 23, 2016
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5HYA
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![BU of 5hya by Molmil](/molmil-images/mine/5hya) | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchangerNCX_Mj soaked with 150 mM Na+ and nominal Ca2+ | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ACETATE ION, CALCIUM ION, ... | Authors: | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | Deposit date: | 2016-02-01 | Release date: | 2016-05-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.897 Å) | Cite: | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger Nat.Struct.Mol.Biol., 23, 2016
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5HWX
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![BU of 5hwx by Molmil](/molmil-images/mine/5hwx) | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 2.5 mM Na+ and zero Ca2+ | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, PENTADECANE, ... | Authors: | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | Deposit date: | 2016-01-29 | Release date: | 2016-05-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger Nat.Struct.Mol.Biol., 23, 2016
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5I41
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![BU of 5i41 by Molmil](/molmil-images/mine/5i41) | Structure of the apo RacA DNA binding domain | Descriptor: | Chromosome-anchoring protein RacA | Authors: | schumacher, M.A. | Deposit date: | 2016-02-11 | Release date: | 2016-05-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular insights into DNA binding and anchoring by the Bacillus subtilis sporulation kinetochore-like RacA protein. Nucleic Acids Res., 44, 2016
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