7SQ6

Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution

Summary for 7SQ6

• Entry DOI: 10.2210/pdb7sq6/pdb
• EMDB information: 25377
• Descriptor: Mucolipin-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, ... (5 entities in total)
• Functional Keywords: ion channel, membrane protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 4
• Total formula weight: 265487.74

Authors

Gan, N.,Han, Y.,Jiang, Y. (deposition date: 2021-11-04, release date: 2022-02-02, Last modification date: 2022-02-23)

• Primary citation: Gan, N.,Han, Y.,Zeng, W.,Wang, Y.,Xue, J.,Jiang, Y.; Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.; Proc.Natl.Acad.Sci.USA, 119:-, 2022; PubMed: 35131932; DOI: 10.1073/pnas.2120404119

Experimental method

ELECTRON MICROSCOPY (2.32 Å)