7SQ6
Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Mucolipin-1 | polymer | 580 | 65573.6 | 4 | UniProt (Q99J21) Pfam (PF21381) Pfam (PF08016) | Mus musculus (house mouse) | Mucolipidin,Transient receptor potential-mucolipin 1,TRPML1 |
| 2 | E, F, G, H (E, F, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | I, K, L, N (A, B, C, D) | 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione | non-polymer | 362.4 | 4 | Chemie (AQV) | |||
| 4 | J, M (A, C) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 262294.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1495.7 | |
| All* | Total formula weight | 265487.7 |
