9K7C
 
 | Crystal structure of GH57 family amylopullulanase from Aquifex aeolicus mutant E256Q in complex with maltopentaose | Descriptor: | GLYCEROL, Glycoside hydrolase family 57 N-terminal domain-containing protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | Authors: | Zhu, Z.M, Wang, W.W, Li, M.J, Xu, Q, Zhou, H, Huang, L.Q, Wang, Q.S, Yu, F. | Deposit date: | 2024-10-23 | Release date: | 2025-06-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The crystal structure of GH57 family amylopullulanase reveals its dual binding pockets sharing the same catalytic dyad. Commun Biol, 8, 2025
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9KYR
 
 | GH57 family amylopullulanase from Aquifex aeolicus D352N mutant complex with gama-cyclodextrin | Descriptor: | 1,2-ETHANEDIOL, Cyclooctakis-(1-4)-(alpha-D-glucopyranose), DI(HYDROXYETHYL)ETHER, ... | Authors: | Zhu, Z.M, Wang, W.W, Yu, F, Li, M.J, Xu, Q, Zhou, H, Huang, L.Q, Wang, Q.S. | Deposit date: | 2024-12-09 | Release date: | 2025-06-04 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Mechanistic insights into cyclodextrins as substrates and inhibitors of GH57 family amylopullulanase from Aquifex aeolicus. J.Struct.Biol., 217, 2025
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9K7D
 
 | Crystal structure of GH57 family amylopullulanase from Aquifex aeolicus mutant E256Q in complex with Maltohexaose | Descriptor: | Glycoside hydrolase family 57 N-terminal domain-containing protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Zhu, Z.M, Wang, W.W, Li, M.J, Xu, Q, Zhou, H, Huang, L.Q, Wang, Q.S, Yu, F. | Deposit date: | 2024-10-23 | Release date: | 2025-06-04 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | The crystal structure of GH57 family amylopullulanase reveals its dual binding pockets sharing the same catalytic dyad. Commun Biol, 8, 2025
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9JLW
 
 | Crystal structure of GH57 family amylopullulanase from Aquifex aeolicus mutant D352N in complex with maltoheptaose | Descriptor: | GLYCEROL, Glycoside hydrolase family 57 N-terminal domain-containing protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | Authors: | Zhu, Z.M, Wang, W.W, Li, M.J, Xu, Q, Zhou, H, Huang, L.Q, Wang, Q.S, Yu, F. | Deposit date: | 2024-09-19 | Release date: | 2025-06-04 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | High-Temperature Crystallization Method for the GH57 Family Hyperthermophilic Amylopullulanase from Aquifex aeolicus Cryst.Growth Des., 24, 2024
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9JLU
 
 | GH57 family amylopullulanase from Aquifex aeolicus D352N mutant complex with beta-cyclodextrin | Descriptor: | Cycloheptakis-(1-4)-(alpha-D-glucopyranose), GLYCEROL, Glycoside hydrolase family 57 N-terminal domain-containing protein | Authors: | Zhu, Z.M, Wang, W.W, Li, M.J, Xu, Q, Zhou, H, Huang, L.Q, Wang, Q.S, Yu, F. | Deposit date: | 2024-09-19 | Release date: | 2025-06-04 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Mechanistic insights into cyclodextrins as substrates and inhibitors of GH57 family amylopullulanase from Aquifex aeolicus. J.Struct.Biol., 217, 2025
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9JLR
 
 | Crystal structure of GH57 family amylopullulanase from Aquifex aeolicus mutant E256Q in complex with maltopentaose | Descriptor: | Glycoside hydrolase family 57 N-terminal domain-containing protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Zhu, Z.M, Wang, W.W, Li, M.J, Xu, Q, Zhou, H, Huang, L.Q, Wang, Q.S, Yu, F. | Deposit date: | 2024-09-19 | Release date: | 2025-06-04 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | High-Temperature Crystallization Method for the GH57 Family Hyperthermophilic Amylopullulanase from Aquifex aeolicus Cryst.Growth Des., 24, 2024
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9JLS
 
 | Crystal structure of GH57 family amylopullulanase from Aquifex aeolicus wild type in complex with acarbose | Descriptor: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, Glycoside hydrolase family 57 N-terminal domain-containing protein | Authors: | Zhu, Z.M, Wang, W.W, Li, M.J, Xu, Q, Zhou, H, Huang, L.Q, Wang, Q.S, Yu, F. | Deposit date: | 2024-09-19 | Release date: | 2025-06-04 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | High-Temperature Crystallization Method for the GH57 Family Hyperthermophilic Amylopullulanase from Aquifex aeolicus Cryst.Growth Des., 24, 2024
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9JLV
 
 | Crystal structure of GH57 family amylopullulanase from Aquifex aeolicus mutant E256Q in complex with alpha-cyclodextrin | Descriptor: | CITRATE ANION, Cyclohexakis-(1-4)-(alpha-D-glucopyranose), GLYCEROL, ... | Authors: | Zhu, Z.M, Wang, W.W, Li, M.J, Xu, Q, Zhou, H, Huang, L.Q, Wang, Q.S, Yu, F. | Deposit date: | 2024-09-19 | Release date: | 2025-06-04 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Mechanistic insights into cyclodextrins as substrates and inhibitors of GH57 family amylopullulanase from Aquifex aeolicus. J.Struct.Biol., 217, 2025
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9JLT
 
 | GH57 family amylopullulanase D352N mutant from Aquifex aeolicus complex with alpha-cyclodextrin | Descriptor: | Cyclohexakis-(1-4)-(alpha-D-glucopyranose), GLYCEROL, Glycoside hydrolase family 57 N-terminal domain-containing protein | Authors: | Zhu, Z.M, Wang, W.W, Li, M.J, Xu, Q, Zhou, H, Huang, L.Q, Wang, Q.S, Yu, F. | Deposit date: | 2024-09-19 | Release date: | 2025-06-04 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Mechanistic insights into cyclodextrins as substrates and inhibitors of GH57 family amylopullulanase from Aquifex aeolicus. J.Struct.Biol., 217, 2025
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6OIE
 
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9IMW
 
 | Crystal structure of N-terminal domain of human Hsp90 | Descriptor: | Heat shock protein HSP 90-alpha | Authors: | Huang, L.Q, Yu, F. | Deposit date: | 2024-07-04 | Release date: | 2025-07-09 | Method: | X-RAY DIFFRACTION (1.527 Å) | Cite: | Novel starting points for fragment-based drug design against human heat shock protein 90 identified using crystallographic fragment screening To Be Published
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7XW9
 
 | Cryo-EM structure of the TRH-bound human TRHR-Gq complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | Authors: | Ji, S, Dong, Y, Chen, L, Zang, S, Shen, D, Guo, J, Qin, J, Zhang, H, Wang, W, Shen, Q, Mao, C, Zhang, Y. | Deposit date: | 2022-05-26 | Release date: | 2022-12-28 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Molecular basis for the activation of thyrotropin-releasing hormone receptor. Cell Discov, 8, 2022
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8J6P
 
 | Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, ... | Authors: | Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y. | Deposit date: | 2023-04-26 | Release date: | 2023-12-06 | Last modified: | 2024-11-13 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nat Commun, 14, 2023
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8J6R
 
 | Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex | Descriptor: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y. | Deposit date: | 2023-04-26 | Release date: | 2023-12-06 | Last modified: | 2024-11-20 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nat Commun, 14, 2023
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8J6Q
 
 | Cryo-EM structure of the 3-HB and compound 9n-bound human HCAR2-Gi1 complex | Descriptor: | (3R)-3-hydroxybutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, ... | Authors: | Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y. | Deposit date: | 2023-04-26 | Release date: | 2023-12-06 | Last modified: | 2024-11-06 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nat Commun, 14, 2023
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4DBF
 
 | Crystal structures of Cg1458 | Descriptor: | 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE, MAGNESIUM ION | Authors: | Ran, T.T, Xu, D.Q, Wang, W.W, Gao, Y.Y, Wang, M.T. | Deposit date: | 2012-01-15 | Release date: | 2012-11-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of Cg1458 reveal a catalytic lid domain and a common catalytic mechanism for FAH family. Biochem.J., 449, 2013
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9IHU
 
 | GH57 family Amylopullulanase from Aquifex aeolicus | Descriptor: | Glycoside hydrolase family 57 N-terminal domain-containing protein | Authors: | Zhu, Z.M, Wang, W.W, Li, M.J, Xu, Q, Zhou, H, Huang, L.Q, Wang, Q.S, Yu, F. | Deposit date: | 2024-06-18 | Release date: | 2025-06-04 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | The crystal structure of GH57 family amylopullulanase reveals its dual binding pockets sharing the same catalytic dyad. Commun Biol, 8, 2025
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7E5Y
 
 | Molecular basis for neutralizing antibody 2B11 targeting SARS-CoV-2 RBD | Descriptor: | 2B11 Fab Heavy chain, 2B11 Fab Light chain, Spike protein S1 | Authors: | Wu, H, Yu, F, Wang, Q.S, Zhou, H, Wang, W.W, Zhao, T, Pan, Y.B, Yang, X.M. | Deposit date: | 2021-02-21 | Release date: | 2021-06-23 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (3.59 Å) | Cite: | Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries. Cell Discov, 7, 2021
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9JLQ
 
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4DBH
 
 | Crystal structure of Cg1458 with inhibitor | Descriptor: | 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE, MAGNESIUM ION, OXALATE ION | Authors: | Ran, T.T, Wang, W.W, Xu, D.Q, Gao, Y.Y. | Deposit date: | 2012-01-15 | Release date: | 2012-11-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Crystal structures of Cg1458 reveal a catalytic lid domain and a common catalytic mechanism for FAH family. Biochem.J., 449, 2013
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8IKJ
 
 | Cryo-EM structure of the inactive CD97 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Adhesion G protein-coupled receptor E5,Soluble cytochrome b562,Adhesion G protein-coupled receptor E5 subunit beta | Authors: | Mao, C, Zhao, R, Dong, Y, Gao, M, Chen, L, Zhang, C, Xiao, P, Guo, J, Qin, J, Shen, D, Ji, S, Zang, S, Zhang, H, Wang, W, Shen, Q, Sun, P, Zhang, Y. | Deposit date: | 2023-02-28 | Release date: | 2024-02-14 | Last modified: | 2025-07-02 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Conformational transitions and activation of the adhesion receptor CD97. Mol.Cell, 84, 2024
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7UHE
 
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9IHW
 
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9II1
 
 | GH57 family Amylopullulanase mutant E256L from Aquifex aeolicus in complex with maltohexaose | Descriptor: | GLYCEROL, Glycoside hydrolase family 57 N-terminal domain-containing protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | Authors: | Zhu, Z.M, Wang, W.W, Yu, F. | Deposit date: | 2024-06-18 | Release date: | 2025-06-04 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | The crystal structure of GH57 family amylopullulanase reveals its dual binding pockets sharing the same catalytic dyad. Commun Biol, 8, 2025
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9II0
 
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