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8UT3
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BU of 8ut3 by Molmil
CryoEM structure of A/Perth/16/2009 H3 in complex with flu HA central stem VH1-18 antibody UCA6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:Huang, J, Han, J, Ward, A.B.
Deposit date:2023-10-30
Release date:2024-05-08
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses.
Immunity, 57, 2024
8UT6
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BU of 8ut6 by Molmil
CryoEM structure of A/Perth/16/2009 H3 in complex with polyclonal Fab from mice immunized with H3 stem nanoparticles-15 days post immunization
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H3D15 pFab HC Fv_polyA, ...
Authors:Huang, J, Han, J, Ward, A.B.
Deposit date:2023-10-30
Release date:2024-05-08
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses.
Immunity, 57, 2024
8WKT
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BU of 8wkt by Molmil
Cryo-EM structure of DSR2-DSAD1 complex
Descriptor: SIR2-like domain-containing protein, SPbeta prophage-derived uncharacterized protein YotI
Authors:Gao, A, Huang, J, Zhu, K.
Deposit date:2023-09-28
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (3.86 Å)
Cite:Molecular basis of bacterial DSR2 anti-phage defense and viral immune evasion.
Nat Commun, 15, 2024
9AYG
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BU of 9ayg by Molmil
Cryo-EM structure of apo state human Cav3.2
Descriptor: 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2024-03-07
Release date:2024-04-24
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 34, 2024
9AYJ
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BU of 9ayj by Molmil
Cryo-EM structure of human Cav3.2 with TTA-P2
Descriptor: 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-dichloro-N-[(1-{[(4S)-2,2-dimethyloxan-4-yl]methyl}-4-fluoropiperidin-4-yl)methyl]benzamide, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2024-03-07
Release date:2024-04-24
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 34, 2024
9AYL
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BU of 9ayl by Molmil
Cryo-EM structure of human Cav3.2 with ACT-709478
Descriptor: 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2024-03-08
Release date:2024-04-24
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 34, 2024
9AYH
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BU of 9ayh by Molmil
Cryo-EM structure of human Cav3.2 with TTA-A2
Descriptor: 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(4-cyclopropylphenyl)-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2024-03-07
Release date:2024-04-24
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 34, 2024
9AYK
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BU of 9ayk by Molmil
Cryo-EM structure of human Cav3.2 with ML218
Descriptor: 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-dichloro-N-{[(1R,5S,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2024-03-08
Release date:2024-04-24
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 34, 2024
5BPP
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BU of 5bpp by Molmil
Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ
Descriptor: 2-(4-butoxyphenyl)-N-hydroxyacetamide, ACETATE ION, Leukotriene A-4 hydrolase, ...
Authors:Huang, J, Dong, N.N, Xiao, Q, Ou, P.Y, Wu, D, Lu, W.Q.
Deposit date:2015-05-28
Release date:2016-08-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H
Sci Rep, 6, 2016
5NUF
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BU of 5nuf by Molmil
Cytosolic Malate Dehydrogenase 1
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Young, D, Messens, J, Huang, J, Reichheld, J.-P.
Deposit date:2017-04-29
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Self-protection of cytosolic malate dehydrogenase against oxidative stress in Arabidopsis.
J. Exp. Bot., 69, 2018
5NUE
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BU of 5nue by Molmil
Cytosolic Malate Dehydrogenase 1 (peroxide-treated)
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-ETHOXYETHANOL, ...
Authors:Young, D, Messens, J, Huang, J, Reichheld, J.-P.
Deposit date:2017-04-29
Release date:2018-02-28
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.35000277 Å)
Cite:Self-protection of cytosolic malate dehydrogenase against oxidative stress in Arabidopsis.
J. Exp. Bot., 69, 2018
8EJM
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BU of 8ejm by Molmil
Crystal structure of human DEAH-box helicase DHX15 in complex with SUGP1 G-patch
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DHX15, CHLORIDE ION, ...
Authors:Huang, J, Tong, L.
Deposit date:2022-09-17
Release date:2022-12-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer.
Proc.Natl.Acad.Sci.USA, 119, 2022
8SX3
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BU of 8sx3 by Molmil
10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Descriptor: 10E8 Fab heavy chain, 10E8 light chain, 10E8-GT10.2 immunogen, ...
Authors:Huang, J, Ozorowski, G, Ward, A.B.
Deposit date:2023-05-19
Release date:2024-05-22
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Vaccination induces broadly neutralizing antibody precursors to HIV gp41.
Nat.Immunol., 2024
4XX0
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BU of 4xx0 by Molmil
CoA bound to pig GTP-specific succinyl-CoA synthetase
Descriptor: COENZYME A, GLYCEROL, PHOSPHATE ION, ...
Authors:Fraser, M.E, Huang, J, Malhi, M.
Deposit date:2015-01-29
Release date:2015-08-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of GTP-specific succinyl-CoA synthetase in complex with CoA.
Acta Crystallogr.,Sect.F, 71, 2015
8T1R
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BU of 8t1r by Molmil
Crystal structure of human CPSF73 catalytic segment in complex with compound 2
Descriptor: 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(3-methoxyphenyl)phenyl]propanamide, CHLORIDE ION, Cleavage and polyadenylation specificity factor subunit 3, ...
Authors:Huang, J, Tong, L.
Deposit date:2023-06-02
Release date:2023-11-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.
Cell Chem Biol, 31, 2024
8T1Q
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BU of 8t1q by Molmil
Crystal structure of human CPSF73 catalytic segment in complex with compound 1
Descriptor: 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(4-ethanoylphenyl)phenyl]propanamide, CHLORIDE ION, Cleavage and polyadenylation specificity factor subunit 3, ...
Authors:Huang, J, Tong, L.
Deposit date:2023-06-02
Release date:2023-11-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.
Cell Chem Biol, 31, 2024
8WKX
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BU of 8wkx by Molmil
Cryo-EM structure of DSR2
Descriptor: SIR2-like domain-containing protein
Authors:Gao, A, Huang, J, Zhu, K.
Deposit date:2023-09-28
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (4.15 Å)
Cite:Molecular basis of bacterial DSR2 anti-phage defense and viral immune evasion.
Nat Commun, 15, 2024
8WKS
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BU of 8wks by Molmil
Cryo-EM structure of DSR2-TUBE complex
Descriptor: SIR2-like domain-containing protein, TUBE
Authors:Gao, A, Huang, J, Zhu, K.
Deposit date:2023-09-28
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Molecular basis of bacterial DSR2 anti-phage defense and viral immune evasion.
Nat Commun, 15, 2024
8E15
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BU of 8e15 by Molmil
A computationally stabilized hMPV F protein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, F1 protein with Fibritin peptide, F2 protein, ...
Authors:Huang, J, Gonzalez, K, Mousa, J, Strauch, E.
Deposit date:2022-08-09
Release date:2023-04-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A general computational design strategy for stabilizing viral class I fusion proteins.
Biorxiv, 2023
8THG
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BU of 8thg by Molmil
Cryo-EM structure of Nav1.7 with RLZ
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2023-07-16
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine.
Proc.Natl.Acad.Sci.USA, 120, 2023
8THH
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BU of 8thh by Molmil
Cryo-EM structure of Nav1.7 with LTG
Descriptor: (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Fan, X, Huang, J, Yan, N.
Deposit date:2023-07-16
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine.
Proc.Natl.Acad.Sci.USA, 120, 2023
8JB4
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BU of 8jb4 by Molmil
lipopolysaccharide-binding domain-LBDB
Descriptor: Antilipopolysaccharide factor D
Authors:Huang, J, Qin, Z.
Deposit date:2023-05-08
Release date:2024-03-13
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Machine learning and genetic algorithm-guided directed evolution for the development of small-molecule antibiotics originating from antimicrobial peptides
To Be Published
8FBC
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BU of 8fbc by Molmil
Crystal structure of P450T2
Descriptor: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
Authors:Pereira, J.H, Huang, J, Keasling, J, Adams, P.D.
Deposit date:2022-11-29
Release date:2023-05-10
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Complete integration of carbene-transfer chemistry into biosynthesis.
Nature, 617, 2023
4I80
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BU of 4i80 by Molmil
Crystal structure of human menin in complex with a high-affinity macrocyclic peptidomimetics
Descriptor: Menin, macrocyclic peptidomimetic
Authors:Huang, J, Lei, M.
Deposit date:2012-12-01
Release date:2013-03-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein-Protein Interaction.
J.Med.Chem., 56, 2013
8H7G
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BU of 8h7g by Molmil
Cryo-EM structure of the human SAGA complex
Descriptor: Ataxin-7, STAGA complex 65 subunit gamma, Splicing factor 3B subunit 3, ...
Authors:Huang, J, Zhang, Y.
Deposit date:2022-10-20
Release date:2022-12-14
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structure of human SAGA transcriptional coactivator complex.
Cell Discov, 8, 2022

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PDB entries from 2024-06-12

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