8UT4

CryoEM structure of A/Michigan/45/2015 H1 in complex with flu HA central stem VH1-18 antibody 09-1B12

Summary for 8UT4

• Entry DOI: 10.2210/pdb8ut4/pdb
• EMDB information: 42529
• Descriptor: Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, 09-1B12 HC Fv, ... (5 entities in total)
• Functional Keywords: flu hemagglutinin, central stem epitope, vh1-18, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Influenza A virus; More
• Total number of polymer chains: 8
• Total formula weight: 223204.77

Authors

Huang, J.,Han, J.,Ward, A.B. (deposition date: 2023-10-30, release date: 2024-05-08, Last modification date: 2024-05-29)

• Primary citation: Ray, R.,Nait Mohamed, F.A.,Maurer, D.P.,Huang, J.,Alpay, B.A.,Ronsard, L.,Xie, Z.,Han, J.,Fernandez-Quintero, M.,Phan, Q.A.,Ursin, R.L.,Vu, M.,Kirsch, K.H.,Prum, T.,Rosado, V.C.,Bracamonte-Moreno, T.,Okonkwo, V.,Bals, J.,McCarthy, C.,Nair, U.,Kanekiyo, M.,Ward, A.B.,Schmidt, A.G.,Batista, F.D.,Lingwood, D.; Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses.; Immunity, 57:1141-1159.e11, 2024; PubMed: 38670113; DOI: 10.1016/j.immuni.2024.03.022

Experimental method

ELECTRON MICROSCOPY (3.3 Å)