4XX0

CoA bound to pig GTP-specific succinyl-CoA synthetase

Summary for 4XX0

• Entry DOI: 10.2210/pdb4xx0/pdb
• Related: 1EUC 1EUD 2FP4 2FPG 2FPI 2FPP
• Descriptor: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial, Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial, COENZYME A, ... (7 entities in total)
• Functional Keywords: ligase, atp-grasp fold
• Biological source: Sus scrofa (Pig); More
• Total number of polymer chains: 2
• Total formula weight: 77558.05

Authors

Fraser, M.E.,Huang, J.,Malhi, M. (deposition date: 2015-01-29, release date: 2015-08-12, Last modification date: 2024-11-13)

Primary citation

Huang, J.,Malhi, M.,Deneke, J.,Fraser, M.E.
Structure of GTP-specific succinyl-CoA synthetase in complex with CoA.
Acta Crystallogr.,Sect.F, 71:1067-1071, 2015

PubMed Abstract: Pig GTP-specific succinyl-CoA synthetase is an αβ-heterodimer. The crystal structure of the complex with the substrate CoA was determined at 2.1 Å resolution. The structure shows CoA bound to the amino-terminal domain of the α-subunit, with the free thiol extending from the adenine portion into the site where the catalytic histidine residue resides.

PubMed: 26249701
DOI: 10.1107/S2053230X15011188

Experimental method

X-RAY DIFFRACTION (2.1 Å)