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6JKJ
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BU of 6jkj by Molmil
Crystal structure of human SPSB2 in the apo-state
Descriptor: SPRY domain-containing SOCS box protein 2
Authors:Luo, Y, Kuang, Z.
Deposit date:2019-03-01
Release date:2019-07-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the SPRY domain of human SPSB2 in the apo state.
Acta Crystallogr.,Sect.F, 75, 2019
7CBZ
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BU of 7cbz by Molmil
Crystal structure of T2R-TTL-A31 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[5-[4-[2-[4-(2-cyclopropylethanoyl)piperazin-1-yl]ethoxy]phenyl]pyridin-2-yl]-N-(phenylmethyl)ethanamide, CALCIUM ION, ...
Authors:Yang, J.H, Yan, W.
Deposit date:2020-06-15
Release date:2021-06-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure.
J.Med.Chem., 64, 2021
6KNZ
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BU of 6knz by Molmil
Crystal structure of T2R-TTL-KXO1 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]-~{N}-(phenylmethyl)ethanamide, CALCIUM ION, ...
Authors:Chen, Q, Yu, Y.
Deposit date:2019-08-07
Release date:2019-10-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.475 Å)
Cite:Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of beta-tubulin explains KXO1's low clinical toxicity.
J.Biol.Chem., 294, 2019
6K9V
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BU of 6k9v by Molmil
Crystal structure of tubulin in complex with inhibitor D64
Descriptor: (5-methoxy-1H-indol-2-yl)-phenyl-methanone, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-06-18
Release date:2019-08-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.543 Å)
Cite:Structural insights into the design of indole derivatives as tubulin polymerization inhibitors.
Febs Lett., 594, 2020
6KEY
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BU of 6key by Molmil
Structural basis for the regulation of inducible nitric oxide synthase (iNOS) by the SPRY domain-containing SOCS box protein 2 (SPSB2)
Descriptor: Nitric oxide synthase, inducible, SPRY domain-containing SOCS box protein 2
Authors:Li, K, Kuang, Z.
Deposit date:2019-07-05
Release date:2020-07-01
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Structural basis for the regulation of inducible nitric oxide synthase by the SPRY domain-containing SOCS box protein SPSB2, an E3 ubiquitin ligase.
Nitric Oxide, 113-114, 2021
6KOX
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BU of 6kox by Molmil
Relaxed state of S65/T66 double-phosphorylated ubiquitin
Descriptor: Polyubiquitin-B
Authors:Dong, X, Tang, C.
Deposit date:2019-08-13
Release date:2019-08-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch.
Protein Cell, 10, 2019
6KOW
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BU of 6kow by Molmil
Retracted state of S65/T66 double-phosphorylated ubiquitin
Descriptor: Polyubiquitin-B
Authors:Dong, X, Tang, C.
Deposit date:2019-08-13
Release date:2019-08-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch.
Protein Cell, 10, 2019
7E2V
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BU of 7e2v by Molmil
Crystal structure of MaDA-3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, MaDA-3
Authors:Gao, L, Du, X, Fan, J, Lei, X.
Deposit date:2021-02-07
Release date:2021-12-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Enzymatic control of endo- and exo-stereoselective Diels-Alder reactions with broad substrate scope.
Nat Catal, 2021
5XIW
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BU of 5xiw by Molmil
Crystal structure of T2R-TTL-Colchicine complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
Authors:Wang, Y, Yang, J, Wang, T, Chen, L.
Deposit date:2017-04-27
Release date:2018-04-18
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 2018
5XP3
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BU of 5xp3 by Molmil
Crystal structure of apo T2R-TTL
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
Authors:Wang, Y, Yang, J, Wang, T, Chen, L.
Deposit date:2017-05-31
Release date:2017-10-25
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 2018
7XED
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BU of 7xed by Molmil
Crystal Structure of OsCIE1-Ubox and OsUBC8 complex
Descriptor: U-box domain-containing protein 12, UBC core domain-containing protein
Authors:Zhang, Y, Yu, C.Z.
Deposit date:2022-03-30
Release date:2023-10-04
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice.
Nature, 629, 2024
7YTV
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BU of 7ytv by Molmil
Crystal structure of Aspergillus fumigatus Thioredoxin reductase in complex with auranofin
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Thioredoxin reductase
Authors:Lin, W.
Deposit date:2022-08-16
Release date:2023-06-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.866 Å)
Cite:In vitro antifungal and antibiofilm activities of auranofin against itraconazole-resistant Aspergillus fumigatus.
J Mycol Med, 33, 2023
7DCL
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BU of 7dcl by Molmil
Crystal structure of the Zn-directed tetramer of the engineered cyt cb 562 variant, C96I/A38S AB5
Descriptor: CHLORIDE ION, HEME C, ZINC ION, ...
Authors:Song, W.J, Yu, J.
Deposit date:2020-10-26
Release date:2021-03-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Symmetry-related residues as promising hotspots for the evolution of de novo oligomeric enzymes.
Chem Sci, 12, 2021
7CNC
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BU of 7cnc by Molmil
cystal structure of human ERH in complex with DGCR8
Descriptor: Enhancer of rudimentary homolog, Microprocessor complex subunit DGCR8
Authors:Li, F, Shen, S.
Deposit date:2020-07-30
Release date:2020-10-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8.
Nucleic Acids Res., 48, 2020
7CI1
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BU of 7ci1 by Molmil
Crystal structure of AcrVA2
Descriptor: 1,2-ETHANEDIOL, AcrVA2, SPERMIDINE
Authors:Chen, P, Cheng, Z, Wang, Y.
Deposit date:2020-07-07
Release date:2020-10-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Study on Anti-CRISPR Protein AcrVA2
Prog.Biochem.Biophys., 2021
7CI2
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BU of 7ci2 by Molmil
Crystal structure of AcrVA2 in complex with partial MbCpf1
Descriptor: AcrVA2, MbCpf1
Authors:Chen, P, Cheng, Z, Wang, Y.
Deposit date:2020-07-07
Release date:2020-10-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Study on Anti-CRISPR Protein AcrVA2
Prog.Biochem.Biophys., 2021
8HIJ
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BU of 8hij by Molmil
The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex
Descriptor: Anti-BRIL Fab heavy chain, Anti-BRIL Fab light chain, Anti-Fab nanobody, ...
Authors:Zhang, Z, Dang, Y.
Deposit date:2022-11-20
Release date:2022-12-21
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Molecular mechanism of substrate recognition by folate transporter SLC19A1.
Cell Discov, 8, 2022
8HII
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BU of 8hii by Molmil
The BRIL-SLC19A1/Fab/Nb ternary complex
Descriptor: BRIL-SLC19A1 chimera, anti-BRIL Fab heavy chain, anti-BRIL Fab light chain, ...
Authors:Zhang, Z, Dang, Y.
Deposit date:2022-11-20
Release date:2022-12-21
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Molecular mechanism of substrate recognition by folate transporter SLC19A1.
Cell Discov, 8, 2022
8HIK
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BU of 8hik by Molmil
The TPP-bound BRIL-SLC19A1/Fab/Nb ternary complex
Descriptor: Anti-BRIL Fab heavy chain, Anti-BRIL Fab light chain, Anti-Fab nanobody, ...
Authors:Zhang, Z, Dang, Y.
Deposit date:2022-11-20
Release date:2022-12-21
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Molecular mechanism of substrate recognition by folate transporter SLC19A1.
Cell Discov, 8, 2022
8HPB
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BU of 8hpb by Molmil
NMR Structure of OsCIE1-Ubox S237D mutant
Descriptor: U-box domain-containing protein 12
Authors:Zhang, Y, Yu, C.Z, Lan, W.X.
Deposit date:2022-12-12
Release date:2023-12-20
Last modified:2024-06-12
Method:SOLUTION NMR
Cite:Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice.
Nature, 629, 2024
8HQB
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BU of 8hqb by Molmil
NMR Structure of OsCIE1-Ubox
Descriptor: U-box domain-containing protein 12
Authors:Zhang, Y, Yu, C.Z, Lan, W.X.
Deposit date:2022-12-13
Release date:2023-12-20
Last modified:2024-06-12
Method:SOLUTION NMR
Cite:Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice.
Nature, 629, 2024
7BVP
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BU of 7bvp by Molmil
AdhE spirosome in extended conformation
Descriptor: Aldehyde-alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION
Authors:Kim, G.J, Song, J.J.
Deposit date:2020-04-11
Release date:2020-06-24
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Aldehyde-alcohol dehydrogenase undergoes structural transition to form extended spirosomes for substrate channeling.
Commun Biol, 3, 2020
1M8R
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BU of 1m8r by Molmil
Crystal Structures of Cadmium-binding Acidic Phospholipase A2 from the Venom of Agkistrodon halys pallas at 1.9 Resolution (crystal grown at pH 7.4)
Descriptor: 1,4-BUTANEDIOL, CADMIUM ION, phospholipase A2
Authors:Xu, S, Gu, L, Zhou, Y, Lin, Z.
Deposit date:2002-07-25
Release date:2003-02-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of cadmium-binding acidic phospholipase A(2) from the venom of Agkistrodon halys Pallas at 1.9A resolutio
Biochem.Biophys.Res.Commun., 300, 2003
8HI8
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BU of 8hi8 by Molmil
Crystal structure of a holoenzyme TglHI with three Fe ions for Pseudomonas syringae Peptidyl (S) 2-mercaptoglycine biosynthesis
Descriptor: DUF692 family protein, FE (III) ION, RiPP Recognition Protein
Authors:Cheng, W, Zheng, Y.H, Fu, X.L.
Deposit date:2022-11-18
Release date:2023-08-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis.
Structure, 31, 2023
8HCI
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BU of 8hci by Molmil
Crystal structure of a holoenzyme Fe-free TglHI for Pseudomonas syringae Peptidyl (S) 2-mercaptoglycine biosynthesis
Descriptor: DUF692 family protein, RiPP Recognition protein
Authors:Cheng, W, Zheng, Y.H, Fu, X.L.
Deposit date:2022-11-01
Release date:2023-08-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.399 Å)
Cite:Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis.
Structure, 31, 2023

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