5YVT

Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+) and NADH

Summary for 5YVT

Entry DOI	10.2210/pdb5yvt/pdb
Descriptor	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	nadh, inhibition, oxidoreductase
Biological source	Homo sapiens (Human) More
Cellular location	Mitochondrion: P50213 P51553
Total number of polymer chains	2
Total formula weight	76904.89
Authors	Ma, T.,Ding, J. (deposition date: 2017-11-27, release date: 2018-03-14, Last modification date: 2023-11-22)
Primary citation	Liu, Y.,Hu, L.,Ma, T.,Yang, J.,Ding, J. Insights into the inhibitory mechanisms of NADH on the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase. Sci Rep, 8:3146-3146, 2018 Cited by PubMed: 29453450 DOI: 10.1038/s41598-018-21584-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation