8H6K
 
 | | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | | Deposit date: | 2022-10-18 | | Release date: | 2024-05-01 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
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8R64
 | | Cryo-EM structure of the FIGNL1 AAA hexamer bound to RAD51 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA repair protein RAD51 homolog 1, ... | | Authors: | Carver, A, Yates, L.A, Zhang, X. | | Deposit date: | 2023-11-20 | | Release date: | 2024-09-04 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin.
Science, 387, 2025
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5TBP
 | | Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003 | | Descriptor: | ACETATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | | Authors: | Aleshin, A.E, Liddington, R.C, Su, Y, Zhang, X. | | Deposit date: | 2016-09-12 | | Release date: | 2017-08-09 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha.
Nat Commun, 8, 2017
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8H6J
 | | Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Zhang, W, Zhan, X, Zhang, X, Lei, J, Yan, C, Shi, Y. | | Deposit date: | 2022-10-18 | | Release date: | 2024-05-01 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
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5V6B
 | | Crystal structure of GIPC1 | | Descriptor: | PDZ domain-containing protein GIPC1 | | Authors: | Shang, G, Zhang, X. | | Deposit date: | 2017-03-16 | | Release date: | 2017-05-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex.
Elife, 6, 2017
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8H6E
 | | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | | Deposit date: | 2022-10-17 | | Release date: | 2024-05-01 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
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8H6L
 | | Cryo-EM structure of human exon-defined spliceosome in the early B state. | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | | Deposit date: | 2022-10-18 | | Release date: | 2024-05-01 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
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5V6R
 | | Structure of Plexin D1 intracellular domain | | Descriptor: | Plexin-D1 | | Authors: | Shang, G, Zhang, X. | | Deposit date: | 2017-03-17 | | Release date: | 2017-05-31 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex.
Elife, 6, 2017
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2L97
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6LZ3
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7NTS
 | | Crystal structure of the SARS-CoV-2 Main Protease with oxidized C145 | | Descriptor: | DIMETHYL SULFOXIDE, FORMIC ACID, GLYCEROL, ... | | Authors: | Dupre, E, Villeret, V, Hanoulle, X. | | Deposit date: | 2021-03-10 | | Release date: | 2021-10-06 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.477 Å) | | Cite: | NMR Spectroscopy of the Main Protease of SARS-CoV-2 and Fragment-Based Screening Identify Three Protein Hotspots and an Antiviral Fragment.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7NLC
 | | Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide | | Descriptor: | AMMONIUM ION, CHLORIDE ION, Protein ORF3, ... | | Authors: | Moschidi, D, Dupre, E, Villeret, V, Hanoulle, X. | | Deposit date: | 2021-02-22 | | Release date: | 2022-03-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.398 Å) | | Cite: | Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide
To Be Published
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7NTQ
 | | Crystal structure of the SARS-CoV-2 Main Protease complexed with N-(pyridin-3-ylmethyl)thioformamide | | Descriptor: | 3C-like proteinase, DIMETHYL SULFOXIDE, FORMIC ACID, ... | | Authors: | Dupre, E, Villeret, V, Hanoulle, X. | | Deposit date: | 2021-03-10 | | Release date: | 2022-03-02 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.495 Å) | | Cite: | Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses.
Eur.J.Med.Chem., 250, 2023
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7NTW
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7NTT
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7YD1
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7YD0
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7YCY
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7YCZ
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8JI0
 | | Cryo-EM structure of the TcsH-CROP in complex with TMPRSS2 | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Hemorrhagic toxin, Transmembrane protease serine 2 | | Authors: | Zhou, R, Tao, L, Zhan, X. | | Deposit date: | 2023-05-25 | | Release date: | 2024-03-20 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin.
Nat Commun, 15, 2024
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8JHZ
 | | Cryo-EM structure of the TcsH-TMPRSS2 complex | | Descriptor: | Hemorrhagic toxin, Transmembrane protease serine 2, ZINC ION | | Authors: | Zhou, R, Liang, T, Zhan, X. | | Deposit date: | 2023-05-25 | | Release date: | 2024-03-20 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin.
Nat Commun, 15, 2024
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7WHK
 | | The state 3 complex structure of Omicron spike with Bn03 (2-up RBD, 5 nanobodies) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bn03_nano1, Bn03_nano2, ... | | Authors: | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | | Deposit date: | 2021-12-30 | | Release date: | 2022-05-11 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody.
Cell, 185, 2022
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7WHI
 | | The state 2 complex structure of Omicron spike with Bn03 (2-up RBD, 4 nanobodies) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bn03_nano1, Bn03_nano2, ... | | Authors: | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | | Deposit date: | 2021-12-30 | | Release date: | 2022-05-11 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody.
Cell, 185, 2022
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7WHJ
 | | The state 1 complex structure of Omicron spike with Bn03 (1-up RBD, 3 nanobodies) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bn03_nano1, Bn03_nano2, ... | | Authors: | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | | Deposit date: | 2021-12-30 | | Release date: | 2022-05-11 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody.
Cell, 185, 2022
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6S8F
 | | Structure of nucleotide-bound Tel1/ATM | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1 | | Authors: | Yates, L.A, Williams, R.M, Ayala, R, Zhang, X. | | Deposit date: | 2019-07-09 | | Release date: | 2019-10-30 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Cryo-EM Structure of Nucleotide-Bound Tel1ATMUnravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations.
Structure, 28, 2020
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