7NTS

Crystal structure of the SARS-CoV-2 Main Protease with oxidized C145

Summary for 7NTS

Entry DOI	10.2210/pdb7nts/pdb
Related	7NTQ 7NTT 7NTW
Descriptor	Replicase polyprotein 1ab, DIMETHYL SULFOXIDE, GLYCEROL, ... (5 entities in total)
Functional Keywords	3clpro, main protease, sars-cov-2, 2019-ncov, cso, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains	1
Total formula weight	34738.53
Authors	Dupre, E.,Villeret, V.,Hanoulle, X. (deposition date: 2021-03-10, release date: 2021-10-06, Last modification date: 2024-01-31)
Primary citation	Cantrelle, F.X.,Boll, E.,Brier, L.,Moschidi, D.,Belouzard, S.,Landry, V.,Leroux, F.,Dewitte, F.,Landrieu, I.,Dubuisson, J.,Deprez, B.,Charton, J.,Hanoulle, X. NMR Spectroscopy of the Main Protease of SARS-CoV-2 and Fragment-Based Screening Identify Three Protein Hotspots and an Antiviral Fragment. Angew.Chem.Int.Ed.Engl., 60:25428-25435, 2021 Cited by PubMed: 34570415 DOI: 10.1002/anie.202109965 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.477 Å)

Structure validation