8T4Y
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![BU of 8t4y by Molmil](/molmil-images/mine/8t4y) | Human HCN1 F186C S264C C309A bound to cAMP, reconstituted in LMNG + SPL | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Authors: | Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B. | Deposit date: | 2023-06-12 | Release date: | 2024-06-19 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Structural basis for hyperpolarization-dependent opening of human HCN1 channel. Nat Commun, 15, 2024
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8T50
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![BU of 8t50 by Molmil](/molmil-images/mine/8t50) | Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Authors: | Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B. | Deposit date: | 2023-06-12 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for hyperpolarization-dependent opening of human HCN1 channel. Nat Commun, 15, 2024
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7UX1
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![BU of 7ux1 by Molmil](/molmil-images/mine/7ux1) | EcMscK in an Open Conformation | Descriptor: | Mechanosensitive channel MscK | Authors: | Mount, J.W, Yuan, P. | Deposit date: | 2022-05-04 | Release date: | 2022-11-23 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel. Nat Commun, 13, 2022
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7UW5
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![BU of 7uw5 by Molmil](/molmil-images/mine/7uw5) | EcMscK G924S mutant in a closed conformation | Descriptor: | Mechanosensitive channel MscK | Authors: | Mount, J.W, Yuan, P. | Deposit date: | 2022-05-02 | Release date: | 2022-11-23 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel. Nat Commun, 13, 2022
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6M97
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![BU of 6m97 by Molmil](/molmil-images/mine/6m97) | Crystal structure of the high-affinity copper transporter Ctr1 | Descriptor: | Chimera protein of High affinity copper uptake protein 1 and Soluble cytochrome b562, HEXATANTALUM DODECABROMIDE, ZINC ION | Authors: | Ren, F, Yuan, P. | Deposit date: | 2018-08-22 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | X-ray structures of the high-affinity copper transporter Ctr1. Nat Commun, 10, 2019
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6M98
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6BBJ
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![BU of 6bbj by Molmil](/molmil-images/mine/6bbj) | Xenopus Tropicalis TRPV4 | Descriptor: | Transient receptor potential cation channel, subfamily V, member 4 | Authors: | Deng, Z, Hite, R.K, Yuan, P. | Deposit date: | 2017-10-18 | Release date: | 2018-02-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms. Nat. Struct. Mol. Biol., 25, 2018
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6C8G
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![BU of 6c8g by Molmil](/molmil-images/mine/6c8g) | Crystal structure of Transient Receptor Potential (TRP) channel TRPV4 in the presence of barium | Descriptor: | BARIUM ION, Transient receptor potential cation channel, subfamily V, ... | Authors: | Deng, Z, Paknejad, N, Maksaev, G, Sala-Rabanal, M, Nichols, C.G, Hite, R.K, Yuan, P. | Deposit date: | 2018-01-24 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (6.31 Å) | Cite: | Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms. Nat. Struct. Mol. Biol., 25, 2018
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6C8H
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![BU of 6c8h by Molmil](/molmil-images/mine/6c8h) | Crystal structure of Transient Receptor Potential (TRP) channel TRPV4 in the presence of gadolinium | Descriptor: | GADOLINIUM ATOM, Transient receptor potential cation channel, subfamily V, ... | Authors: | Deng, Z, Paknejad, N, Maksaev, G, Sala-Rabanal, M, Nichols, C.G, Hite, R.K, Yuan, P. | Deposit date: | 2018-01-24 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (6.5 Å) | Cite: | Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms. Nat. Struct. Mol. Biol., 25, 2018
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6CD2
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![BU of 6cd2 by Molmil](/molmil-images/mine/6cd2) | Crystal structure of the PapC usher bound to the chaperone-adhesin PapD-PapG | Descriptor: | Chaperone protein PapD, Outer membrane usher protein PapC, PapGII adhesin protein | Authors: | Omattage, N.S, Deng, Z, Yuan, P, Hultgren, S.J. | Deposit date: | 2018-02-07 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli. Nat Microbiol, 3, 2018
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6C8F
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![BU of 6c8f by Molmil](/molmil-images/mine/6c8f) | Crystal structure of Transient Receptor Potential (TRP) channel TRPV4 in the presence of cesium | Descriptor: | CESIUM ION, Transient receptor potential cation channel, subfamily V, ... | Authors: | Deng, Z, Paknejad, N, Maksaev, G, Sala-Rabanal, M, Nichols, C.G, Hite, R.K, Yuan, P. | Deposit date: | 2018-01-24 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (6.5 Å) | Cite: | Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms. Nat. Struct. Mol. Biol., 25, 2018
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5IT3
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![BU of 5it3 by Molmil](/molmil-images/mine/5it3) | Swirm domain of human Lsd1 | Descriptor: | Lysine-specific histone demethylase 1A, MAGNESIUM ION | Authors: | Jeffrey, P.D, Yuan, P. | Deposit date: | 2016-03-16 | Release date: | 2016-05-18 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | A Tlx-interacting peptide of Lsd1 inhibits the proliferation of brain tumor stem cells To Be Published
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5KUK
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![BU of 5kuk by Molmil](/molmil-images/mine/5kuk) | Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant | Descriptor: | ATP-sensitive inward rectifier potassium channel 12, DECYL-BETA-D-MALTOPYRANOSIDE, POTASSIUM ION | Authors: | Lee, S.-J, Ren, F, Heyman, S, Yuan, P, Nichols, C.G. | Deposit date: | 2016-07-13 | Release date: | 2016-08-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids. J.Gen.Physiol., 148, 2016
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5KUM
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![BU of 5kum by Molmil](/molmil-images/mine/5kum) | Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant In Complex with PIP2 | Descriptor: | ATP-sensitive inward rectifier potassium channel 12, DECYL-BETA-D-MALTOPYRANOSIDE, POTASSIUM ION, ... | Authors: | Lee, S.-J, Ren, F, Heyman, S, Yuan, P, Nichols, C.G. | Deposit date: | 2016-07-13 | Release date: | 2016-08-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids. J.Gen.Physiol., 148, 2016
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6UW6
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![BU of 6uw6 by Molmil](/molmil-images/mine/6uw6) | Cryo-EM structure of the human TRPV3 K169A mutant determined in lipid nanodisc | Descriptor: | Transient receptor potential cation channel subfamily V member 3, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Deng, Z, Yuan, P. | Deposit date: | 2019-11-04 | Release date: | 2020-07-01 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Gating of human TRPV3 in a lipid bilayer. Nat.Struct.Mol.Biol., 27, 2020
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6UW9
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6UW4
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![BU of 6uw4 by Molmil](/molmil-images/mine/6uw4) | Cryo-EM structure of human TRPV3 determined in lipid nanodisc | Descriptor: | SODIUM ION, Transient receptor potential cation channel subfamily V member 3, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Deng, Z, Yuan, P. | Deposit date: | 2019-11-04 | Release date: | 2020-07-01 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Gating of human TRPV3 in a lipid bilayer. Nat.Struct.Mol.Biol., 27, 2020
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6V6D
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![BU of 6v6d by Molmil](/molmil-images/mine/6v6d) | Cryo-EM structure of human pannexin 1 | Descriptor: | Pannexin-1 | Authors: | Deng, Z, He, Z, Yuan, P. | Deposit date: | 2019-12-05 | Release date: | 2020-04-01 | Last modified: | 2020-04-22 | Method: | ELECTRON MICROSCOPY (3.77 Å) | Cite: | Cryo-EM structures of the ATP release channel pannexin 1. Nat.Struct.Mol.Biol., 27, 2020
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6UW8
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6UZY
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![BU of 6uzy by Molmil](/molmil-images/mine/6uzy) | Cryo-EM structure of Xenopus tropicalis pannexin 1 | Descriptor: | HEXADECANE, Pannexin, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Deng, Z, He, Z, Yuan, P. | Deposit date: | 2019-11-15 | Release date: | 2020-04-01 | Last modified: | 2020-04-22 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Cryo-EM structures of the ATP release channel pannexin 1. Nat.Struct.Mol.Biol., 27, 2020
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6V5A
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![BU of 6v5a by Molmil](/molmil-images/mine/6v5a) | Crystal structure of the human BK channel gating ring L390P mutant | Descriptor: | CALCIUM ION, Calcium-activated potassium channel subunit alpha-1, SULFATE ION | Authors: | Deng, Z, Yuan, P. | Deposit date: | 2019-12-03 | Release date: | 2020-07-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Coupling of Ca2+and voltage activation in BK channels through the alpha B helix/voltage sensor interface. Proc.Natl.Acad.Sci.USA, 117, 2020
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6VXN
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![BU of 6vxn by Molmil](/molmil-images/mine/6vxn) | Cryo-EM structure of Arabidopsis thaliana MSL1 A320V | Descriptor: | DODECANE, Mechanosensitive ion channel protein 1, mitochondrial | Authors: | Deng, Z, Zhang, J, Yuan, P. | Deposit date: | 2020-02-22 | Release date: | 2020-08-05 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance. Nat Commun, 11, 2020
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6VXM
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![BU of 6vxm by Molmil](/molmil-images/mine/6vxm) | Cryo-EM structure of Arabidopsis thaliana MSL1 | Descriptor: | EICOSANE, Mechanosensitive ion channel protein 1, mitochondrial | Authors: | Deng, Z, Zhang, J, Yuan, P. | Deposit date: | 2020-02-22 | Release date: | 2020-08-05 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance. Nat Commun, 11, 2020
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6VXP
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8F7C
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![BU of 8f7c by Molmil](/molmil-images/mine/8f7c) | Cryo-EM structure of human pannexin 2 | Descriptor: | Pannexin-2, Soluble cytochrome b562 fusion | Authors: | He, Z, Yuan, P. | Deposit date: | 2022-11-18 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.92 Å) | Cite: | Structural and functional analysis of human pannexin 2 channel. Nat Commun, 14, 2023
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