3HM3
 
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8G6G
 | | H2BK120ub+H3K79me2-modified nucleosome ubiquitin position 5 | | Descriptor: | 601 DNA (185-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Hicks, C.W, Wolberger, C, Keogh, M. | | Deposit date: | 2023-02-15 | | Release date: | 2024-02-21 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch.
Nucleic Acids Res., 52, 2024
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8G6Q
 | | H2AK119ub-modified nucleosome ubiquitin position 1 | | Descriptor: | 601 DNA (147-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Hicks, C.W, Wolberger, C, Keogh, M. | | Deposit date: | 2023-02-15 | | Release date: | 2024-02-21 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (3.41 Å) | | Cite: | Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch.
Nucleic Acids Res., 52, 2024
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8G6S
 | | H2AK119ub-modified nucleosome ubiquitin position 2 | | Descriptor: | 601 DNA (147-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Hicks, C.W, Wolberger, C, Keogh, M. | | Deposit date: | 2023-02-15 | | Release date: | 2024-02-21 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch.
Nucleic Acids Res., 52, 2024
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8G6H
 | | H2BK120ub+H3K79me2-modified nucleosome ubiquitin position 6 | | Descriptor: | 601 DNA (185-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Hicks, C.W, Wolberger, C, Keogh, M. | | Deposit date: | 2023-02-15 | | Release date: | 2024-02-21 | | Last modified: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch.
Nucleic Acids Res., 52, 2024
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6NOG
 | | Poised-state Dot1L bound to the H2B-Ubiquitinated nucleosome | | Descriptor: | 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ... | | Authors: | Worden, E.J, Hoffmann, N.A, Wolberger, C. | | Deposit date: | 2019-01-16 | | Release date: | 2019-02-20 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.
Cell, 176, 2019
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6NJ9
 | | Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 2-to-1 complex | | Descriptor: | 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ... | | Authors: | Worden, E.J, Hoffmann, N.A, Wolberger, C. | | Deposit date: | 2019-01-02 | | Release date: | 2019-02-20 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.
Cell, 176, 2019
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6NQA
 | | Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 1-to-1 complex | | Descriptor: | 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ... | | Authors: | Worden, E.J, Hoffmann, N.A, Wolberger, C. | | Deposit date: | 2019-01-19 | | Release date: | 2019-02-20 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.
Cell, 176, 2019
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4TWI
 | | The structure of Sir2Af1 bound to a succinylated histone peptide | | Descriptor: | GLYCEROL, NAD-dependent protein deacylase 1, Succinylated H4 Peptide (aa8-20), ... | | Authors: | Ringel, A.E, Roman, C, Wolberger, C. | | Deposit date: | 2014-06-30 | | Release date: | 2014-12-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.
Protein Sci., 23, 2014
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1YRN
 | | CRYSTAL STRUCTURE OF THE MATA1/MATALPHA2 HOMEODOMAIN HETERODIMER BOUND TO DNA | | Descriptor: | DNA (5'-D(*TP*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*TP*AP*TP*TP*AP*C P*AP*TP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*GP*AP*TP*GP*TP*AP*AP*TP*AP*AP*AP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MAT A1 HOMEODOMAIN), ... | | Authors: | Li, T, Stark, M.R, Johnson, A.D, Wolberger, C. | | Deposit date: | 1995-11-02 | | Release date: | 1996-01-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA.
Science, 270, 1995
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4R62
 | | Structure of Rad6~Ub | | Descriptor: | ACETATE ION, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 2 | | Authors: | Kumar, P, Wolberger, C. | | Deposit date: | 2014-08-22 | | Release date: | 2015-09-02 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity.
Nucleic Acids Res., 43, 2015
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4R7E
 | | Structure of Bre1 RING domain | | Descriptor: | E3 ubiquitin-protein ligase BRE1, ZINC ION | | Authors: | Kumar, P, Wolberger, C. | | Deposit date: | 2014-08-27 | | Release date: | 2015-05-13 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.251 Å) | | Cite: | Structure of the yeast Bre1 RING domain.
Proteins, 83, 2015
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3D4B
 | | Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+ | | Descriptor: | 5'-O-[(R)-{[(R)-{[(3R,4R)-1-(3-carbamoylbenzyl)-4-hydroxypyrrolidin-3-yl]methoxy}(hydroxy)phosphoryl]methyl}(hydroxy)phosphoryl]adenosine, Acetyl P53 peptide, NAD-dependent deacetylase, ... | | Authors: | Hawse, W.F, Hoff, K.G, Fatkins, D, Daines, A, Zubkova, O.V, Schramm, V.L, Zheng, W, Wolberger, C. | | Deposit date: | 2008-05-14 | | Release date: | 2008-09-30 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural insights into intermediate steps in the Sir2 deacetylation reaction.
Structure, 16, 2008
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3D81
 | | Sir2-S-alkylamidate complex crystal structure | | Descriptor: | NAD-dependent deacetylase, S-alkylamidate intermediate, ZINC ION | | Authors: | Hawse, W.F, Hoff, K.G, Fatkins, D, Daines, A, Zubkova, O.V, Schramm, V.L, Zheng, W, Wolberger, C. | | Deposit date: | 2008-05-22 | | Release date: | 2008-09-30 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural insights into intermediate steps in the Sir2 deacetylation reaction.
Structure, 16, 2008
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3CZ6
 | | Crystal Structure of the Rap1 C-terminus | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA-binding protein RAP1 | | Authors: | Feeser, E.A, Wolberger, C. | | Deposit date: | 2008-04-28 | | Release date: | 2008-05-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.
J.Mol.Biol., 380, 2008
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8T3W
 | | Structure of Bre1-nucleosome complex - state2 | | Descriptor: | 601 DNA strand 1, 601 DNA strand 2, E3 ubiquitin-protein ligase BRE1, ... | | Authors: | Zhao, F, Hicks, C.W, Wolberger, C. | | Deposit date: | 2023-06-07 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Mechanism of histone H2B monoubiquitination by Bre1.
Nat.Struct.Mol.Biol., 30, 2023
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8T3Y
 | | Structure of Bre1-nucleosome complex - state1 | | Descriptor: | 601 DNA Strand 1, 601 DNA Strand 2, E3 ubiquitin-protein ligase BRE1, ... | | Authors: | Zhao, F, Hicks, C.W, Wolberger, C. | | Deposit date: | 2023-06-08 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Mechanism of histone H2B monoubiquitination by Bre1.
Nat.Struct.Mol.Biol., 30, 2023
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8T3T
 | | Structure of Bre1-nucleosome complex - state3 | | Descriptor: | 601 DNA strand 1, 601 DNA strand 2, E3 ubiquitin-protein ligase BRE1, ... | | Authors: | Zhao, F, Hicks, C.W, Wolberger, C. | | Deposit date: | 2023-06-07 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Mechanism of histone H2B monoubiquitination by Bre1.
Nat.Struct.Mol.Biol., 30, 2023
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1AWC
 | | MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA | | Descriptor: | DNA (5'-D(*AP*AP*(BRU)P*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*AP*(CBR)P*AP*CP*(CBR)P*GP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*CP*GP*GP*(BRU)P*GP*(BRU)P*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP*AP*T)-3'), PROTEIN (GA BINDING PROTEIN ALPHA), ... | | Authors: | Batchelor, A.H, Wolberger, C. | | Deposit date: | 1997-10-01 | | Release date: | 1998-03-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA.
Science, 279, 1998
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8V25
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8V28
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8V26
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8V27
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1B72
 | | PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX | | Descriptor: | DNA (5'-D(*AP*CP*TP*CP*TP*AP*TP*GP*AP*TP*TP*GP*AP*TP*CP*GP*GP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*CP*CP*GP*AP*TP*CP*AP*AP*TP*CP*AP*TP*AP*GP*AP*G)-3'), PROTEIN (HOMEOBOX PROTEIN HOX-B1), ... | | Authors: | Piper, D.E, Batchelor, A.H, Chang, C.-P, Cleary, M.L, Wolberger, C. | | Deposit date: | 1999-01-27 | | Release date: | 1999-02-19 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation.
Cell(Cambridge,Mass.), 96, 1999
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4DHI
 | | Structure of C. elegans OTUB1 bound to human UBC13 | | Descriptor: | Ubiquitin thioesterase otubain-like, Ubiquitin-conjugating enzyme E2 N | | Authors: | Wiener, R, Zhang, X, Wang, T, Wolberger, C. | | Deposit date: | 2012-01-27 | | Release date: | 2012-02-22 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The mechanism of OTUB1-mediated inhibition of ubiquitination.
Nature, 483, 2012
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