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2BYT
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BU of 2byt by Molmil
Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the post-editing conformation
Descriptor: LEUCINE, LEUCYL-TRNA SYNTHETASE, MERCURY (II) ION, ...
Authors:Cusack, S, Tukalo, M, Yaremchuk, A, Fukunaga, R, Yokoyama, S.
Deposit date:2005-08-04
Release date:2005-09-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer-Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
6Z6B
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BU of 6z6b by Molmil
Structure of full-length La Crosse virus L protein (polymerase)
Descriptor: RNA (5'-R(*GP*CP*UP*AP*CP*UP*AP*A)-3'), RNA (5'-R(P*AP*GP*UP*AP*GP*UP*GP*UP*GP*C)-3'), RNA (5'-R(P*UP*UP*AP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3'), ...
Authors:Cusack, S, Gerlach, P, Reguera, J.
Deposit date:2020-05-28
Release date:2020-07-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.961 Å)
Cite:Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
8P0G
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BU of 8p0g by Molmil
Thogoto virus polymerase in Mode A conformation and bound to 35-mer loop promoter RNA
Descriptor: 5'RNA, MAGNESIUM ION, Polymerase acidic protein, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2023-05-10
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Thogoto virus polymerase
To Be Published
8P0B
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BU of 8p0b by Molmil
Thogoto virus polymerase in Mode B conformation and bound to 32-mer loop promoter RNA
Descriptor: 3'RNA, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2023-05-10
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (2.87 Å)
Cite:Thogoto virus polymerase
To Be Published
8P0U
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BU of 8p0u by Molmil
Thogoto virus polymerase in Mode B conformation with defined endonuclease domain and bound to 32-mer loop promoter RNA
Descriptor: 3'RNA, MAGNESIUM ION, Polymerase acidic protein, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2023-05-10
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Thogoto virus polymerase
To Be Published
1H4V
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BU of 1h4v by Molmil
HISTIDYL-TRNA SYNTHETASE from Thermus Thermophilus (ligand free)
Descriptor: HISTIDYL-TRNA SYNTHETASE, SULFATE ION
Authors:Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:2001-05-14
Release date:2001-06-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase
J.Mol.Biol., 309, 2001
6QCV
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BU of 6qcv by Molmil
Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP
Descriptor: CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Cusack, S, Drncova, P.
Deposit date:2018-12-31
Release date:2019-06-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCW
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BU of 6qcw by Molmil
Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer
Descriptor: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Cusack, S, Drncova, P.
Deposit date:2018-12-31
Release date:2019-06-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCT
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BU of 6qct by Molmil
Influenza B polymerase elongation complex
Descriptor: 3 end, 5 end, MAGNESIUM ION, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2018-12-30
Release date:2019-06-05
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCS
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BU of 6qcs by Molmil
Influenza B polymerase pre-initiation complex
Descriptor: 3 end, 5 end, Capped RNA, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2018-12-30
Release date:2019-06-05
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6F7S
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BU of 6f7s by Molmil
Crystal structure of Human ARS2 residues 147-270 + 408-763 with deletion of loop B
Descriptor: Serrate RNA effector molecule homolog, Serrate RNA effector molecule homolog,Serrate RNA effector molecule homolog
Authors:Cusack, S, Schulze, W.M.
Deposit date:2017-12-11
Release date:2018-05-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.37 Å)
Cite:Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
Nat Commun, 9, 2018
6F7J
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BU of 6f7j by Molmil
Crystal structure of Human ARS2 residues 171-270 + 408-763
Descriptor: Serrate RNA effector molecule homolog
Authors:Cusack, S, Schulze, W.M.
Deposit date:2017-12-10
Release date:2018-05-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
Nat Commun, 9, 2018
6F7P
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BU of 6f7p by Molmil
Crystal structure of Human ARS2 residues 147-270 + 408-763
Descriptor: Serrate RNA effector molecule homolog
Authors:Cusack, S, Schulze, W.M.
Deposit date:2017-12-11
Release date:2018-05-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
Nat Commun, 9, 2018
6FLM
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BU of 6flm by Molmil
Crystal structure of the human TRIM25 PRYSPRY domain
Descriptor: CHLORIDE ION, E3 ubiquitin/ISG15 ligase TRIM25, SULFATE ION
Authors:Cusack, S, Kowalinski, E.
Deposit date:2018-01-26
Release date:2018-05-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.009 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
6F8D
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BU of 6f8d by Molmil
Crystal structure of Human ARS2 residues 171-270 + 408-763 (P65 form)
Descriptor: Serrate RNA effector molecule homolog
Authors:Cusack, S, Schulze, W.M.
Deposit date:2017-12-13
Release date:2018-05-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
Nat Commun, 9, 2018
6FLN
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BU of 6fln by Molmil
Crystal structure of the human TRIM25 coiled-coil and PRYSPRY domains
Descriptor: E3 ubiquitin/ISG15 ligase TRIM25
Authors:Cusack, S, Lethier, M.
Deposit date:2018-01-26
Release date:2018-05-23
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
7QTL
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BU of 7qtl by Molmil
Influenza A/H7N9 polymerase elongation complex
Descriptor: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2022-01-14
Release date:2022-12-28
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.48 Å)
Cite:Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
8BE0
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BU of 8be0 by Molmil
Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the C +1 position
Descriptor: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2022-10-20
Release date:2022-12-28
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.34 Å)
Cite:Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
8BDR
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BU of 8bdr by Molmil
Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position
Descriptor: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2022-10-19
Release date:2022-12-28
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
8BEK
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BU of 8bek by Molmil
Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position
Descriptor: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2022-10-21
Release date:2022-12-28
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
8BF5
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BU of 8bf5 by Molmil
Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP analogue
Descriptor: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2022-10-24
Release date:2022-12-28
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
5JCH
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BU of 5jch by Molmil
Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.95 A resolution (untwinned).
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ...
Authors:Cusack, S, Uchikawa, E.
Deposit date:2016-04-15
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Mol.Cell, 62, 2016
5JC7
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BU of 5jc7 by Molmil
Crystal structure of chicken MDA5 with 5'p 24-mer dsRNA and ADP-Mg2+ at 2.75 A resolution.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ...
Authors:Cusack, S, Uchikawa, E.
Deposit date:2016-04-14
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Mol.Cell, 62, 2016
7R1F
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BU of 7r1f by Molmil
Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106
Descriptor: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2022-02-02
Release date:2022-12-28
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
7R0E
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BU of 7r0e by Molmil
Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position
Descriptor: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2022-02-01
Release date:2022-12-28
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.51 Å)
Cite:Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023

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