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4Z46
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BU of 4z46 by Molmil
X-ray structure of the bis-platinum lysozyme adduct formed in the reaction between the protein and the two drugs Cisplatin and Oxaliplatin
Descriptor: 1,2-ETHANEDIOL, CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II), Cisplatin, ...
Authors:Merlino, A.
Deposit date:2015-04-01
Release date:2015-05-27
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Oxaliplatin vs. cisplatin: competition experiments on their binding to lysozyme.
Dalton Trans, 44, 2015
4ZFP
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BU of 4zfp by Molmil
A new crystal structure for the adduct formed in the reaction between AuSac2, a cytotoxic homoleptic gold(I) compound with the saccharinate ligand, and the model protein hen egg white lysozyme
Descriptor: 1,2-ETHANEDIOL, GOLD ION, Lysozyme C, ...
Authors:Merlino, A.
Deposit date:2015-04-21
Release date:2015-06-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme.
Biometals, 28, 2015
4ESA
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BU of 4esa by Molmil
X-ray structure of carbonmonoxy hemoglobin of Eleginops maclovinus
Descriptor: CARBON MONOXIDE, GLYCEROL, Hemoglobin alpha chain, ...
Authors:Merlino, A, Vitagliano, L, Mazzarella, L, Vergara, A.
Deposit date:2012-04-23
Release date:2012-11-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus.
Mol Biosyst, 8, 2012
4S18
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BU of 4s18 by Molmil
The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and oxaliplatin
Descriptor: CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II), Ribonuclease pancreatic
Authors:Merlino, A.
Deposit date:2015-01-09
Release date:2015-11-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts.
J.Inorg.Biochem., 153, 2015
4S1Y
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BU of 4s1y by Molmil
X-ray structure of human serum albumin complexed with cisplatin
Descriptor: Cisplatin, Serum albumin
Authors:Merlino, A.
Deposit date:2015-01-16
Release date:2015-04-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Cisplatin binding to human serum albumin: a structural study.
Chem.Commun.(Camb.), 51, 2015
4IRO
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BU of 4iro by Molmil
Crystal structure of T-state carbonmonoxy hemoglobin from Trematomus bernacchii at pH 8.4
Descriptor: CARBON MONOXIDE, Hemoglobin subunit alpha, Hemoglobin subunit beta, ...
Authors:Merlino, A, Balsamo, A, Mazzarella, L, Vergara, A.
Deposit date:2013-01-15
Release date:2013-02-20
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Role of tertiary structures on the Root effect in fish hemoglobins.
Biochim.Biophys.Acta, 1834, 2013
7R1Q
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BU of 7r1q by Molmil
X-ray structure of the adduct formed upon reaction of the gold(I) N-heterocyclic carbene complex Au2 with lysozyme
Descriptor: DIMETHYL SULFOXIDE, GOLD ION, Lysozyme
Authors:Merlino, A, Ferraro, G.
Deposit date:2022-02-03
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Halo complexes of gold(I) containing glycoconjugate carbene ligands: synthesis, characterization, cytotoxicity and interaction with proteins and DNA model systems.
Dalton Trans, 51, 2022
7R1P
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BU of 7r1p by Molmil
X-ray structure of the adduct formed upon reaction of the gold(I) N-heterocyclic carbene complex Au1 with RNase A
Descriptor: GOLD ION, Ribonuclease pancreatic, SULFATE ION
Authors:Merlino, A, Ferraro, G.
Deposit date:2022-02-03
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Halo complexes of gold(I) containing glycoconjugate carbene ligands: synthesis, characterization, cytotoxicity and interaction with proteins and DNA model systems.
Dalton Trans, 51, 2022
7NQB
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BU of 7nqb by Molmil
X.ray structure of the oxaliplatin/beta-lactoglobulin adduct
Descriptor: Beta-lactoglobulin, PLATINUM (II) ION
Authors:Merlino, A, Loreto, D, Ferraro, G.
Deposit date:2021-03-01
Release date:2022-03-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Protein-Based Delivery Systems for Anticancer Metallodrugs: Structure and Biological Activity of the Oxaliplatin/ beta-Lactoglobulin Adduct.
Pharmaceuticals, 15, 2022
5E5E
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BU of 5e5e by Molmil
X-ray structure of the adduct formed in the reaction between RNase A and a neutral organometallic derivative [Pt(pbi)(Me)(DMSO)], pbi=2-(2'-pyridil)benzimidazole (compound 3)
Descriptor: DIMETHYL SULFOXIDE, PLATINUM (II) ION, Ribonuclease pancreatic
Authors:Merlino, A.
Deposit date:2015-10-08
Release date:2015-12-09
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Cytotoxic properties of a new organometallic platinum(ii) complex and its gold(i) heterobimetallic derivatives.
Dalton Trans, 45, 2015
6XW0
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BU of 6xw0 by Molmil
X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (low resolution)
Descriptor: ACETATE ION, RHODIUM(III) ION, Ribonuclease pancreatic
Authors:Merlino, A, Ferraro, G.
Deposit date:2020-01-22
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Protein interactions of dirhodium tetraacetate: a structural study.
Dalton Trans, 49, 2020
6RJV
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BU of 6rjv by Molmil
The X-ray structure of the Gold/Serum Albumin adduct obtained upon reaction of the protein with AuL12, a gold(III) dithiocarbamate complex
Descriptor: GOLD ION, MAGNESIUM ION, Serum albumin
Authors:Merlino, A, Giorgio, A, Ferraro, G.
Deposit date:2019-04-29
Release date:2019-08-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Structural Characterization of a Gold/Serum Albumin Complex.
Inorg.Chem., 58, 2019
6XVX
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BU of 6xvx by Molmil
X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (high resolution)
Descriptor: ACETATE ION, RHODIUM(III) ION, Ribonuclease pancreatic
Authors:Merlino, A, Ferraro, G.
Deposit date:2020-01-22
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Protein interactions of dirhodium tetraacetate: a structural study.
Dalton Trans, 49, 2020
5E5F
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BU of 5e5f by Molmil
X-ray structure of the complex between RNase A and compound 4-PF6 ([(PPh3)Au(mi-pbi)Pt(Me)(DMSO)][PF6]), the heterobimetallic derivative obtained in the reaction between the organometallic compound [Pt(pbi)(Me)(DMSO)], pbi=2-(2'-pyridil)benzimidazole (compound 3) and the gold(I) compound [Au(Ph3P)][PF6]
Descriptor: ACETATE ION, GOLD ION, Ribonuclease pancreatic, ...
Authors:Merlino, A.
Deposit date:2015-10-08
Release date:2015-12-09
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Cytotoxic properties of a new organometallic platinum(ii) complex and its gold(i) heterobimetallic derivatives.
Dalton Trans, 45, 2015
6QEA
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BU of 6qea by Molmil
The X-ray structure of the adduct formed in the reaction between hen egg white lysozyme and complex I, a pentacoordinate Pt(II) compound containing 2,9-dimethyl-1,10-phenanthroline, dimethylfumarate, methyl and iodine as ligands
Descriptor: DIMETHYL SULFOXIDE, Lysozyme C, NITRATE ION, ...
Authors:Merlino, A, Ferraro, G.
Deposit date:2019-01-07
Release date:2019-03-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Reaction with Proteins of a Five-Coordinate Platinum(II) Compound.
Int J Mol Sci, 20, 2019
6QE9
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BU of 6qe9 by Molmil
The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and complex I, a pentacoordinate Pt(II) compound containing 2,9-dimethyl-1,10-phenanthroline, dimethylfumarate, methyl and iodine as ligands
Descriptor: Ribonuclease pancreatic, SULFATE ION, pentacoordinate Pt(II) compound
Authors:Merlino, A, Ferraro, G.
Deposit date:2019-01-07
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Reaction with Proteins of a Five-Coordinate Platinum(II) Compound.
Int J Mol Sci, 20, 2019
7OR6
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BU of 7or6 by Molmil
The crystal structure of the domain-swapped dimer of onconase
Descriptor: Protein P-30
Authors:Merlino, A, Loreto, D.
Deposit date:2021-06-04
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:The crystal structure of the domain-swapped dimer of onconase highlights some catalytic and antitumor activity features of the enzyme.
Int.J.Biol.Macromol., 191, 2021
7ORD
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BU of 7ord by Molmil
The crystal structure of the domain-swapped dimer of onconase (2)
Descriptor: ACETATE ION, Protein P-30, SULFATE ION
Authors:Merlino, A, Loreto, D.
Deposit date:2021-06-05
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:The crystal structure of the domain-swapped dimer of onconase highlights some catalytic and antitumor activity features of the enzyme.
Int.J.Biol.Macromol., 191, 2021
4Z41
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BU of 4z41 by Molmil
X-ray structure of the adduct formed in the reaction between lysozyme and a platinum(II) Compound with a S,O Bidentate Ligand (9a=Chloro-(1-(3'-hydroxy)-3-(methylthio)-3-thioxo-prop-1-en-1-olate-O,S)-(dimethylsulfoxide-S)-platinum(II))
Descriptor: 1,2-ETHANEDIOL, 3-[2-chloranyl-2-[dimethyl(oxidanyl)-{4}-sulfanyl]-4-ethylsulfanyl-1-oxa-3{3}-thia-2{4}-platinacyclohexa-3,5-dien-6-yl]phenol, DIMETHYL SULFOXIDE, ...
Authors:Merlino, A.
Deposit date:2015-04-01
Release date:2015-09-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding.
Inorg.Chem., 54, 2015
4ZEE
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BU of 4zee by Molmil
X-ray structure of the bis-platinum lysozyme adduct formed in the reaction between the protein and the two drugs Cisplatin and Oxaliplatin (preparation 2)
Descriptor: 1,2-ETHANEDIOL, CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II), Cisplatin, ...
Authors:Merlino, A.
Deposit date:2015-04-20
Release date:2015-05-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Oxaliplatin vs. cisplatin: competition experiments on their binding to lysozyme.
Dalton Trans, 44, 2015
4Z3M
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BU of 4z3m by Molmil
X-ray structure of the adduct formed in the reaction between lysozyme and a platinum(II) Complex with S,O Bidentate Ligands (9b)
Descriptor: 1,2-ETHANEDIOL, 3-[2-chloranyl-2-[dimethyl(oxidanyl)-{4}-sulfanyl]-4-ethylsulfanyl-1-oxa-3{3}-thia-2{4}-platinacyclohexa-3,5-dien-6-yl]phenol, DIMETHYL SULFOXIDE, ...
Authors:Merlino, A.
Deposit date:2015-03-31
Release date:2015-09-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding.
Inorg.Chem., 54, 2015
5ILF
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BU of 5ilf by Molmil
The X-ray structure of the adduct formed in the reaction between hen egg white lysozyme and compound 4, a platin(II) compound containing a O, S bidentate ligand
Descriptor: ACETATE ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Merlino, A, Ferraro, G.
Deposit date:2016-03-04
Release date:2016-12-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Platinum(ii) O,S complexes as potential metallodrugs against Cisplatin resistance.
Dalton Trans, 45, 2016
4L2D
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BU of 4l2d by Molmil
X-ray structure of the Fe(II) form of the iron superoxide dismutase from Pseudoalteromonas haloplanktis
Descriptor: FE (II) ION, Superoxide dismutase [Fe], alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose
Authors:Russo Krauss, I, Merlino, A, Sica, F.
Deposit date:2013-06-04
Release date:2014-02-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability.
Biochim.Biophys.Acta, 1844, 2014
4L2C
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BU of 4l2c by Molmil
X-ray structure of the C57R mutant of the iron superoxide dismutase from Pseudoalteromonas haloplanktis (crystal form I)
Descriptor: FE (III) ION, Superoxide dismutase [Fe], alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose
Authors:Russo Krauss, I, Merlino, A, Sica, F.
Deposit date:2013-06-04
Release date:2014-02-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability.
Biochim.Biophys.Acta, 1844, 2014
5ILC
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BU of 5ilc by Molmil
The X-ray structure of the adduct formed in the reaction between hen egg white lysozyme a compound 2, a platin(II) compound containing a O, S bidentate ligand
Descriptor: ACETATE ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Merlino, A, Ferraro, G.
Deposit date:2016-03-04
Release date:2016-12-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Platinum(ii) O,S complexes as potential metallodrugs against Cisplatin resistance.
Dalton Trans, 45, 2016

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