6RJV

The X-ray structure of the Gold/Serum Albumin adduct obtained upon reaction of the protein with AuL12, a gold(III) dithiocarbamate complex

Summary for 6RJV

Entry DOI	10.2210/pdb6rjv/pdb
Descriptor	Serum albumin, MAGNESIUM ION, GOLD ION, ... (4 entities in total)
Functional Keywords	transport protein
Biological source	Bos taurus (Bovine)
Total number of polymer chains	2
Total formula weight	133566.48
Authors	Merlino, A.,Giorgio, A.,Ferraro, G. (deposition date: 2019-04-29, release date: 2019-08-14, Last modification date: 2024-11-13)
Primary citation	Pratesi, A.,Cirri, D.,Fregona, D.,Ferraro, G.,Giorgio, A.,Merlino, A.,Messori, L. Structural Characterization of a Gold/Serum Albumin Complex. Inorg.Chem., 58:10616-10619, 2019 Cited by PubMed Abstract: The medicinal gold(III) dithiocarbamato complex AuL forms a stable adduct with bovine serum albumin. The crystal structure reveals that a single gold(I) center is bound to Cys34, with the dithiocarbamato ligand being released. To the best of our knowledge, this is the first structure for a gold adduct of serum albumin. PubMed: 31361466 DOI: 10.1021/acs.inorgchem.9b01900 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.21 Å)

Structure validation