8HIX
 
 | | Cryo-EM structure of GPR21_m5_Gs | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Chen, B, Lin, X, Xu, F. | | Deposit date: | 2022-11-22 | | Release date: | 2023-03-15 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Cryo-EM structures of orphan GPR21 signaling complexes.
Nat Commun, 14, 2023
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9B9P
 | | Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex with Mg2+, and JK-5-114 | | Descriptor: | 6-hydroxy-2-phenyl[1,3]thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione, Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION | | Authors: | Kurz, J.L, Lin, X, Guddat, L.W. | | Deposit date: | 2024-04-03 | | Release date: | 2025-04-09 | | Last modified: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (3.18 Å) | | Cite: | A Ketol-Acid Reductoisomerase Inhibitor That Has Antituberculosis and Herbicidal Activity.
Chemistry, 31, 2025
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9BAE
 | | Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex with Mg2+, and JK-5-115 | | Descriptor: | 6-hydroxy-2-phenyl[1,3]thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione, Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION | | Authors: | Kurz, J.L, Lin, X, Guddat, L.W. | | Deposit date: | 2024-04-03 | | Release date: | 2025-04-09 | | Last modified: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | A Ketol-Acid Reductoisomerase Inhibitor That Has Antituberculosis and Herbicidal Activity.
Chemistry, 31, 2025
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6LI1
 | | Crystal structure of GPR52 ligand free form with flavodoxin fusion | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Chimera of G-protein coupled receptor 52 and Flavodoxin, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Luo, Z.P, Lin, X, Xu, F, Han, G.W. | | Deposit date: | 2019-12-10 | | Release date: | 2020-02-26 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis of ligand recognition and self-activation of orphan GPR52.
Nature, 579, 2020
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6LI0
 | | Crystal structure of GPR52 in complex with agonist c17 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CITRATE ANION, Chimera of G-protein coupled receptor 52 and Flavodoxin, ... | | Authors: | Luo, Z.P, Lin, X, Xu, F, Han, G.W. | | Deposit date: | 2019-12-10 | | Release date: | 2020-02-26 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis of ligand recognition and self-activation of orphan GPR52.
Nature, 579, 2020
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6LI2
 | | Crystal structure of GPR52 ligand free form with rubredoxin fusion | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Chimera of G-protein coupled receptor 52 and Rubredoxin, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Luo, Z.P, Lin, X, Xu, F, Han, G.W. | | Deposit date: | 2019-12-10 | | Release date: | 2020-02-26 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of ligand recognition and self-activation of orphan GPR52.
Nature, 579, 2020
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8HJ1
 | | GPR21(wt) and Gs complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Chen, B, Lin, X, Xu, F. | | Deposit date: | 2022-11-22 | | Release date: | 2023-12-27 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | Cryo-EM structures of orphan GPR21 signaling complexes.
Nat Commun, 14, 2023
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8J9N
 | | Gq bound FZD1 in ligand-free state | | Descriptor: | Frizzled-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Lin, X, Xu, F. | | Deposit date: | 2023-05-04 | | Release date: | 2024-01-17 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Cell Discov, 10, 2024
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8J9O
 | | Cryo-EM structure of inactive FZD1 | | Descriptor: | Frizzled-1,Soluble cytochrome b562, anti-BRIL Fab Heavy Chain, anti-BRIL Fab Light Chain, ... | | Authors: | Lin, X, Xu, F. | | Deposit date: | 2023-05-04 | | Release date: | 2024-01-17 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Cell Discov, 10, 2024
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8K0U
 | | Crystal structure of theophylline DNA aptamer bound to hypoxanthine | | Descriptor: | DNA (29-MER), HYPOXANTHINE, POTASSIUM ION, ... | | Authors: | Huang, Y, Lin, X, Huang, L. | | Deposit date: | 2023-07-10 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | From Theophylline to Adenine or preQ 1 : Repurposing a DNA Aptamer Revealed by Crystal Structure Analysis.
Angew.Chem.Int.Ed.Engl., 64, 2025
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8K0T
 | | Crystal structure of theophylline DNA aptamer bound to theophylline | | Descriptor: | DNA (29-MER), IODIDE ION, POTASSIUM ION, ... | | Authors: | Huang, Y, Lin, X, Huang, L. | | Deposit date: | 2023-07-10 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | From Theophylline to Adenine or preQ 1 : Repurposing a DNA Aptamer Revealed by Crystal Structure Analysis.
Angew.Chem.Int.Ed.Engl., 64, 2025
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8K0W
 | | Crystal structure of theophylline DNA aptamer bound to theophylline, soaked in Selenourea | | Descriptor: | DNA (29-MER), MAGNESIUM ION, SODIUM ION, ... | | Authors: | Huang, Y, Lin, X, Huang, L. | | Deposit date: | 2023-07-10 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | From Theophylline to Adenine or preQ 1 : Repurposing a DNA Aptamer Revealed by Crystal Structure Analysis.
Angew.Chem.Int.Ed.Engl., 64, 2025
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8K0V
 | | Crystal structure of theophylline DNA aptamer bound to 3-methylxanthine | | Descriptor: | 3-methyl-7~{H}-purine-2,6-dione, DNA (29-MER), SODIUM ION | | Authors: | Huang, Y, Lin, X, Huang, L. | | Deposit date: | 2023-07-10 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | From Theophylline to Adenine or preQ 1 : Repurposing a DNA Aptamer Revealed by Crystal Structure Analysis.
Angew.Chem.Int.Ed.Engl., 64, 2025
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8Y03
 | | Crystal structure of LbCas12a-crRNA complex | | Descriptor: | LbCas12a, MAGNESIUM ION, RNA (41-MER) | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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8Y05
 | | Crystal structure of LbCas12a in complex with crRNA and 9nt target DNA | | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*TP*T)-3'), DNA (5'-D(P*CP*TP*GP*GP*AP*TP*GP*CP*GP*TP*AP*AP*AP*GP*GP*AP*CP*G)-3'), LbCas12a, ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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8Y06
 | | Crystal structure of LbCas12a in complex with crRNA and 12nt target DNA | | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*TP*T)-3'), DNA (5'-D(P*TP*TP*AP*CP*TP*GP*GP*AP*TP*GP*CP*GP*TP*AP*AP*AP*GP*GP*AP*CP*G)-3'), LbCas12a, ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.99 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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8Y09
 | | Crystal structure of LbCas12a in complex with crRNA and 15nt target DNA | | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*TP*T)-3'), DNA (5'-D(P*CP*TP*TP*TP*AP*CP*TP*GP*GP*AP*TP*GP*CP*GP*TP*AP*AP*AP*GP*GP*AP*CP*G)-3'), LITHIUM ION, ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.87 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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8Y07
 | | Crystal structure of LbCas12a in complex with crRNA and 13nt target DNA | | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*TP*T)-3'), DNA (5'-D(P*TP*TP*TP*AP*CP*TP*GP*GP*AP*TP*GP*CP*GP*TP*AP*AP*AP*GP*GP*AP*CP*G)-3'), LITHIUM ION, ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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8Y0A
 | | Crystal structure of LbCas12a in complex with crRNA and 18nt target DNA | | Descriptor: | DNA (27-MER), DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*TP*T)-3'), LbCas12a, ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.51 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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8Y04
 | | Crystal structure of LbCas12a in complex with crRNA and 6nt target DNA | | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*TP*T)-3'), DNA (5'-D(P*GP*AP*TP*GP*CP*GP*TP*AP*AP*AP*GP*GP*AP*CP*G)-3'), LbCas12a, ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.71 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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8Y0B
 | | Crystal structure of FnCas12a in complex with pre-crRNA and 12nt target DNA | | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*AP*AP*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*AP*GP*GP*AP*CP*T)-3'), DNA (5'-D(P*AP*GP*TP*CP*CP*TP*TP*TP*AP*GP*AP*TP*A)-3'), ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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8Y08
 | | Crystal structure of LbCas12a in complex with crRNA and 14nt target DNA | | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*TP*T)-3'), DNA (5'-D(P*CP*TP*TP*TP*AP*CP*TP*GP*GP*AP*TP*GP*CP*GP*TP*AP*AP*AP*GP*GP*AP*CP*G)-3'), LITHIUM ION, ... | | Authors: | Lin, X, Chen, J, Liu, L. | | Deposit date: | 2024-01-22 | | Release date: | 2025-01-01 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.64 Å) | | Cite: | DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.
Nucleic Acids Res., 53, 2025
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1DDJ
 | | CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN | | Descriptor: | PLASMINOGEN | | Authors: | Wang, X, Terzyan, S, Tang, J, Loy, J, Lin, X, Zhang, X. | | Deposit date: | 1999-11-10 | | Release date: | 2000-02-18 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Human plasminogen catalytic domain undergoes an unusual conformational change upon activation.
J.Mol.Biol., 295, 2000
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6WIV
 | | Structure of human GABA(B) receptor in an inactive state | | Descriptor: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-{[(9Z)-octadec-9-enoyl]oxy}propyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Park, J, Fu, Z, Frangaj, A, Liu, J, Mosyak, L, Shen, T, Slavkovich, V.N, Ray, K.M, Taura, J, Cao, B, Geng, Y, Zuo, H, Kou, Y, Grassucci, R, Chen, S, Liu, Z, Lin, X, Williams, J.P, Rice, W.J, Eng, E.T, Huang, R.K, Soni, R.K, Kloss, B, Yu, Z, Javitch, J.A, Hendrickson, W.A, Slesinger, P.A, Quick, M, Graziano, J, Yu, H, Fiehn, O, Clarke, O.B, Frank, J, Fan, Q.R. | | Deposit date: | 2020-04-10 | | Release date: | 2020-07-01 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of human GABABreceptor in an inactive state.
Nature, 584, 2020
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3KBK
 | | Epi-isozizaene synthase complexed with Hg | | Descriptor: | CHLORIDE ION, Epi-isozizaene synthase, MERCURY (II) ION, ... | | Authors: | Aaron, J.A, Lin, X, Cane, D.E, Christianson, D.W. | | Deposit date: | 2009-10-20 | | Release date: | 2010-02-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates
Biochemistry, 49, 2010
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