6IZW
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![BU of 6izw by Molmil](/molmil-images/mine/6izw) | Myxococcus xanthus MglA bound to GTP-gamma-S and MglB | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Gliding motility protein MglB, MAGNESIUM ION, ... | Authors: | Baranwal, J, Gayathri, P. | Deposit date: | 2018-12-20 | Release date: | 2019-10-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Allosteric regulation of a prokaryotic small Ras-like GTPase contributes to cell polarity oscillations in bacterial motility. Plos Biol., 17, 2019
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4Y1H
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![BU of 4y1h by Molmil](/molmil-images/mine/4y1h) | Crystal structure of K33 linked tri-Ubiquitin | Descriptor: | 1,2-ETHANEDIOL, Ubiquitin-40S ribosomal protein S27a | Authors: | Kristariyanto, Y.A, Abdul Rehman, S.A, Choi, S.Y, Ritorto, S, Campbell, D.G, Morrice, N.A, Toth, R, Kulathu, Y. | Deposit date: | 2015-02-07 | Release date: | 2015-03-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations. Biochem.J., 467, 2015
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4XYZ
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![BU of 4xyz by Molmil](/molmil-images/mine/4xyz) | Crystal structure of K33 linked di-Ubiquitin | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, IODIDE ION, ... | Authors: | Kristariyanto, Y.A, Abdul Rehman, S.A, Choi, S.Y, Ritorto, S, Campbell, D.G, Morrice, N.A, Toth, R, Kulathu, Y. | Deposit date: | 2015-02-03 | Release date: | 2015-03-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations. Biochem.J., 467, 2015
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5KR4
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![BU of 5kr4 by Molmil](/molmil-images/mine/5kr4) | Directed Evolution of Transaminases By Ancestral Reconstruction. Using Old Proteins for New Chemistries | Descriptor: | 1,2-ETHANEDIOL, 4-aminobutyrate transaminase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Wilding, M, Newman, J, Peat, T.S, Scott, C. | Deposit date: | 2016-07-06 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction Green Chemistry, 19, 2017
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5KR6
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![BU of 5kr6 by Molmil](/molmil-images/mine/5kr6) | Directed Evolution of Transaminases By Ancestral Reconstruction. Using Old Proteins for New Chemistries | Descriptor: | 4-aminobutyrate transaminase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Wilding, M, Newman, J, Peat, T.S, Scott, C. | Deposit date: | 2016-07-07 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction Green Chemistry, 19, 2017
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5KQU
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![BU of 5kqu by Molmil](/molmil-images/mine/5kqu) | Directed Evolution of Transaminases By Ancestral Reconstruction. Using Old Proteins for New Chemistries | Descriptor: | 4-aminobutyrate transaminase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Wilding, M, Newman, J, Peat, T.S, Scott, C. | Deposit date: | 2016-07-06 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction Green Chemistry, 19, 2017
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5KQT
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![BU of 5kqt by Molmil](/molmil-images/mine/5kqt) | Directed Evolution of Transaminases By Ancestral Reconstruction. Using Old Proteins for New Chemistries | Descriptor: | 4-aminoburyrate transaminase, CHLORIDE ION, GLYCEROL, ... | Authors: | Wilding, M, Newman, J, Peat, T.S, Scott, C. | Deposit date: | 2016-07-06 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction Green Chemistry, 19, 2017
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5KR3
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![BU of 5kr3 by Molmil](/molmil-images/mine/5kr3) | Directed Evolution of Transaminases By Ancestral Reconstruction. Using Old Proteins for New Chemistries | Descriptor: | 4-aminobutyrate transaminase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Wilding, M, Newman, J, Peat, T.S, Scott, C. | Deposit date: | 2016-07-06 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction Green Chemistry, 19, 2017
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5KQW
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![BU of 5kqw by Molmil](/molmil-images/mine/5kqw) | Directed Evolution of Transaminases By Ancestral Reconstruction. Using Old Proteins for New Chemistries | Descriptor: | 1,2-ETHANEDIOL, 4-aminobutyrate transaminase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wilding, M, Newman, J, Peat, T.S, Scott, C. | Deposit date: | 2016-07-06 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction Green Chemistry, 19, 2017
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5KR5
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![BU of 5kr5 by Molmil](/molmil-images/mine/5kr5) | Directed Evolution of Transaminases By Ancestral Reconstruction. Using Old Proteins for New Chemistries | Descriptor: | 4-aminobutyrate transaminase, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wilding, M, Newman, J, Peat, T.S, Scott, C. | Deposit date: | 2016-07-07 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction Green Chemistry, 19, 2017
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1VGE
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![BU of 1vge by Molmil](/molmil-images/mine/1vge) | |
6SRR
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![BU of 6srr by Molmil](/molmil-images/mine/6srr) | |
4XZH
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![BU of 4xzh by Molmil](/molmil-images/mine/4xzh) | Crystal structure of human Aldose Reductase complexed with NADP+ and JF0048 | Descriptor: | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [3-(4-chloro-3-nitrobenzyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetic acid | Authors: | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Dominguez, M, de Lera, A.R, Farres, J, Pares, X, Podjarny, A. | Deposit date: | 2015-02-04 | Release date: | 2015-11-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. Chemmedchem, 10, 2015
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4XZI
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![BU of 4xzi by Molmil](/molmil-images/mine/4xzi) | Crystal structure of human Aldose Reductase complexed with NADP+ and JF0049 | Descriptor: | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2,4-dioxo-3-(2,3,4,5-tetrabromo-6-methoxybenzyl)-3,4-dihydropyrimidin-1(2H)-yl]acetic acid | Authors: | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Dominguez, M, de Lera, A.R, Farres, J, Pares, X, Podjarny, A. | Deposit date: | 2015-02-04 | Release date: | 2015-11-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. Chemmedchem, 10, 2015
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4XZN
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![BU of 4xzn by Molmil](/molmil-images/mine/4xzn) | Crystal structure of the methylated K125R/V301L AKR1B10 Holoenzyme | Descriptor: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Podjarny, A. | Deposit date: | 2015-02-04 | Release date: | 2015-11-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. Chemmedchem, 10, 2015
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4XZL
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![BU of 4xzl by Molmil](/molmil-images/mine/4xzl) | Crystal structure of human AKR1B10 complexed with NADP+ and JF0049 | Descriptor: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Dominguez, M, de Lera, A.R, Farres, J, Pares, X, Podjarny, A. | Deposit date: | 2015-02-04 | Release date: | 2015-11-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. Chemmedchem, 10, 2015
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6SQU
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![BU of 6squ by Molmil](/molmil-images/mine/6squ) | Crystal structure of human SHIP2 catalytic domain in complex with 1,2,4 Dimer | Descriptor: | 5,5'-(ethane-1,2-diylbis(oxy))bis(benzene-5,4,2,1,-tetrayl)hexakisphosphate, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | Authors: | Whitfield, H, Brearley, C.A, Hemmings, A.M. | Deposit date: | 2019-09-04 | Release date: | 2021-01-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention. J.Med.Chem., 64, 2021
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4XZM
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![BU of 4xzm by Molmil](/molmil-images/mine/4xzm) | Crystal structure of the methylated wild-type AKR1B10 holoenzyme | Descriptor: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Podjarny, A. | Deposit date: | 2015-02-04 | Release date: | 2015-11-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. Chemmedchem, 10, 2015
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4WT2
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![BU of 4wt2 by Molmil](/molmil-images/mine/4wt2) | Co-crystal Structure of MDM2 in Complex with AM-7209 | Descriptor: | 4-({[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl}amino)-2-methoxybenzoic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | Authors: | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | Deposit date: | 2014-10-30 | Release date: | 2014-12-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction. J.Med.Chem., 57, 2014
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4YBH
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![BU of 4ybh by Molmil](/molmil-images/mine/4ybh) | |
1JZT
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![BU of 1jzt by Molmil](/molmil-images/mine/1jzt) | |
1MOR
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![BU of 1mor by Molmil](/molmil-images/mine/1mor) | |
1MOQ
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![BU of 1moq by Molmil](/molmil-images/mine/1moq) | ISOMERASE DOMAIN OF GLUCOSAMINE 6-PHOSPHATE SYNTHASE COMPLEXED WITH GLUCOSAMINE 6-PHOSPHATE | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-amino-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, ... | Authors: | Teplyakov, A. | Deposit date: | 1997-04-11 | Release date: | 1998-10-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6-phosphate synthase: evidence from a 1.6 A crystal structure of the isomerase domain. Structure, 6, 1998
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1RXD
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![BU of 1rxd by Molmil](/molmil-images/mine/1rxd) | Crystal structure of human protein tyrosine phosphatase 4A1 | Descriptor: | protein tyrosine phosphatase type IVA, member 1; Protein tyrosine phosphatase IVA1 | Authors: | Sun, J.P, Fedorov, A.A, Almo, S.C, Zhang, Z.Y, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2003-12-18 | Release date: | 2004-12-28 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM., 8, 2007
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7BKG
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![BU of 7bkg by Molmil](/molmil-images/mine/7bkg) | Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the tricyclic inhibitor (2) | Descriptor: | 5,6-dihydro-2-imino-2H,4H-thiazolo(5,4,3-IJ)quinoline, Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Schreuder, H.A, Liesum, A. | Deposit date: | 2021-01-15 | Release date: | 2021-03-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.326 Å) | Cite: | Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders. Molecules, 26, 2021
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