6SRR

Crystal structure of human SHIP2 catalytic domain

Summary for 6SRR

Entry DOI	10.2210/pdb6srr/pdb
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (2 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	72487.70
Authors	Whitfield, H.,Brearley, C.A.,Hemmings, A.M. (deposition date: 2019-09-05, release date: 2021-01-13, Last modification date: 2024-01-24)
Primary citation	Whitfield, H.,Hemmings, A.M.,Mills, S.J.,Baker, K.,White, G.,Rushworth, S.,Riley, A.M.,Potter, B.V.L.,Brearley, C.A. Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention. J.Med.Chem., 64:3813-3826, 2021 Cited by PubMed: 33724834 DOI: 10.1021/acs.jmedchem.0c01944 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation