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Crystal structure of adenosine deaminase from Plasmodium vivax in complex with pentostatin
Descriptor:	2'-DEOXYCOFORMYCIN, ACETONITRILE, ZINC ION, ...
Authors:	Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-04-10
Release date:	2007-04-24
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J.Mol.Biol., 381, 2008

2A0M

Arginase superfamily protein from Trypanosoma cruzi
Descriptor:	ARGINASE SUPERFAMILY PROTEIN, CHLORIDE ION
Authors:	Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-06-16
Release date:	2005-07-05
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.603 Å)
Cite:	Structural genomics of pathogenic protozoa: an overview. Methods Mol.Biol., 426, 2008

2F8M

Ribose 5-phosphate isomerase from Plasmodium falciparum
Descriptor:	PHOSPHATE ION, ribose 5-phosphate isomerase
Authors:	Holmes, M.A, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-12-02
Release date:	2005-12-27
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.087 Å)
Cite:	Structure of ribose 5-phosphate isomerase from Plasmodium falciparum. Acta Crystallogr.,Sect.F, 62, 2006

3EIY

Crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei with bound pyrophosphate
Descriptor:	DI(HYDROXYETHYL)ETHER, Inorganic pyrophosphatase, POTASSIUM ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2008-09-17
Release date:	2008-09-30
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	The role of medical structural genomics in discovering new drugs for infectious diseases. PLoS Comput Biol, 5, 2009

3EJ0

Crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei with bound N-(pyridin-3-ylmethyl) aniline, H32 crystal form
Descriptor:	Inorganic pyrophosphatase, N-(pyridin-3-ylmethyl)aniline
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2008-09-17
Release date:	2008-09-30
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.96 Å)
Cite:	The role of medical structural genomics in discovering new drugs for infectious diseases. PLoS Comput Biol, 5, 2009

3FOC

Tryptophanyl-tRNA synthetase from Giardia lamblia
Descriptor:	GLYCEROL, SULFATE ION, Tryptophanyl-tRNA synthetase
Authors:	Arakaki, T.L, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2008-12-29
Release date:	2009-01-13
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.09 Å)
Cite:	The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. J.Struct.Biol., 171, 2010

1X9G

PUTATIVE MAR1 RIBONUCLEASE FROM LEISHMANIA DONOVANI
Descriptor:	PUTATIVE MAR1
Authors:	Caruthers, J, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2004-08-20
Release date:	2004-09-07
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.41 Å)
Cite:	Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci., 14, 2005

1YZV

HYPOTHETICAL PROTEIN FROM TRYPANOSOMA CRUZI
Descriptor:	HYPOTHETICAL PROTEIN, SULFATE ION
Authors:	Caruthers, J, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-02-28
Release date:	2005-03-08
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.001 Å)
Cite:	Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci., 14, 2005

1XN4

PUTATIVE MAR1 RIBONUCLEASE FROM LEISHMANIA MAJOR
Descriptor:	ribonuclease MAR1
Authors:	Caruthers, J, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2004-10-04
Release date:	2004-10-12
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (3.8 Å)
Cite:	Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci., 14, 2005

1CJ4

MUTANT Q34T OF PARA-HYDROXYBENZOATE HYDROXYLASE
Descriptor:	FLAVIN-ADENINE DINUCLEOTIDE, P-HYDROXYBENZOIC ACID, PROTEIN (P-HYDROXYBENZOATE HYDROXYLASE)
Authors:	Eppink, M.H.M, Overkamp, K.M, Schreuder, H.A, Van Berkel, W.J.H.
Deposit date:	1999-04-21
Release date:	1999-04-30
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Switch of coenzyme specificity of p-hydroxybenzoate hydroxylase. J.Mol.Biol., 292, 1999

1CJ3

MUTANT TYR38GLU OF PARA-HYDROXYBENZOATE HYDROXYLASE
Descriptor:	FLAVIN-ADENINE DINUCLEOTIDE, P-HYDROXYBENZOIC ACID, PROTEIN (P-HYDROXYBENZOATE HYDROXYLASE)
Authors:	Eppink, M.H.M, Overkamp, K.M, Schreuder, H.A, Van Berkel, W.J.H.
Deposit date:	1999-04-21
Release date:	1999-04-30
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Switch of coenzyme specificity of p-hydroxybenzoate hydroxylase. J.Mol.Biol., 292, 1999

1TSI

STRUCTURE OF THE COMPLEX BETWEEN TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AND N-HYDROXY-4-PHOSPHONO-BUTANAMIDE: BINDING AT THE ACTIVE SITE DESPITE AN "OPEN" FLEXIBLE LOOP
Descriptor:	N-HYDROXY-4-PHOSPHONO-BUTANAMIDE, TRIOSEPHOSPHATE ISOMERASE
Authors:	Verlinde, C.L.M.J.
Deposit date:	1992-11-19
Release date:	1994-01-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.84 Å)
Cite:	Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop conformation. Protein Sci., 1, 1992

1PHH

CRYSTAL STRUCTURE OF P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH ITS REACTION PRODUCT 3,4-DIHYDROXYBENZOATE
Descriptor:	3,4-DIHYDROXYBENZOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, P-HYDROXYBENZOATE HYDROXYLASE
Authors:	Schreuder, H.A, Drenth, J.
Deposit date:	1987-11-04
Release date:	1988-04-16
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal structure of p-hydroxybenzoate hydroxylase complexed with its reaction product 3,4-dihydroxybenzoate. J.Mol.Biol., 199, 1988

4Y5Q

Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with AMP
Descriptor:	ADENOSINE MONOPHOSPHATE, CALCIUM ION, Calmodulin-domain protein kinase 1, ...
Authors:	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2015-02-11
Release date:	2015-02-25
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with AMP To Be Published

3K81

Structure of the central interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies
Descriptor:	MP18 RNA editing complex protein, Single strand antibody VHH domain
Authors:	Park, Y.-J, Hol, W.
Deposit date:	2009-10-13
Release date:	2010-11-17
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (3.4 Å)
Cite:	Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. J.Struct.Biol., 174, 2011

2AR1

Structure of Hypothetical protein from Leishmania major
Descriptor:	GLYCEROL, hypothetical protein
Authors:	Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-08-18
Release date:	2005-08-30
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.602 Å)
Cite:	Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major. Acta Crystallogr.,Sect.F, 62, 2006

2B4G

dihydroorotate dehydrogenase
Descriptor:	BROMIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:	Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-09-23
Release date:	2005-10-11
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies Mol.Microbiol., 68, 2008

1OXY

CRYSTALLOGRAPHIC ANALYSIS OF OXYGENATED AND DEOXYGENATED STATES OF ARTHROPOD HEMOCYANIN SHOWS UNUSUAL DIFFERENCES
Descriptor:	COPPER (II) ION, HEMOCYANIN (SUBUNIT TYPE II), OXYGEN MOLECULE
Authors:	Ton-that, H, Magnus, K.
Deposit date:	1995-01-06
Release date:	1995-02-27
Last modified:	2024-06-05
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences. Proteins, 19, 1994

1FX7

CRYSTAL STRUCTURE OF THE IRON-DEPENDENT REGULATOR (IDER) FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:	COBALT (II) ION, IRON-DEPENDENT REPRESSOR IDER, SULFATE ION
Authors:	Feese, M.D, Ingason, B.P, Goranson-Siekierke, J, Holmes, R.K, Hol, W.J.G.
Deposit date:	2000-09-25
Release date:	2001-03-07
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystal structure of the iron-dependent regulator from Mycobacterium tuberculosis at 2.0-A resolution reveals the Src homology domain 3-like fold and metal binding function of the third domain. J.Biol.Chem., 276, 2001

3P0I

Leishmania major Tyrosyl-tRNA synthetase in complex with tyrosinol, cubic crystal form
Descriptor:	4-[(2S)-2-amino-3-hydroxypropyl]phenol, Tyrosyl-tRNA synthetase
Authors:	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-09-28
Release date:	2011-03-23
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (3.13 Å)
Cite:	The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011

3P0J

Leishmania major Tyrosyl-tRNA synthetase in complex with tyrosinol, triclinic crystal form 1
Descriptor:	4-[(2S)-2-amino-3-hydroxypropyl]phenol, SODIUM ION, Tyrosyl-tRNA synthetase
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-09-28
Release date:	2011-03-23
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.89 Å)
Cite:	The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011

3P0H

Leishmania major Tyrosyl-tRNA synthetase in complex with fisetin, cubic crystal form
Descriptor:	3,7,3',4'-TETRAHYDROXYFLAVONE, Tyrosyl-tRNA synthetase
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-09-28
Release date:	2011-03-23
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011

4ONA

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1517
Descriptor:	5-amino-1-tert-butyl-3-(7-ethoxyquinolin-3-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-01-28
Release date:	2014-03-19
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett, 5, 2014

3SX9

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-132
Descriptor:	3-(6-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Larson, E.T, Merritt, E.A.
Deposit date:	2011-07-14
Release date:	2012-03-14
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J.Med.Chem., 55, 2012

3KSV

Hypothetical protein from Leishmania major
Descriptor:	Uncharacterized protein, ZINC ION
Authors:	Han, G.W, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2009-11-23
Release date:	2010-01-12
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Hypothetical protein (HIT family) from Leishmania major To be Published

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