5XS0
| Structure of a ssDNA bound to the outer DNA binding site of RAD52 | Descriptor: | DNA repair protein RAD52 homolog, ssDNA (5'-D(*CP*CP*CP*CP*CP*C)-3'), ssDNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*C)-3'), ... | Authors: | Saotome, M, Saito, K, Yasuda, T, Sugiyama, S, Kurumizaka, H, Kagawa, W. | Deposit date: | 2017-06-11 | Release date: | 2018-04-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Basis of Homology-Directed DNA Repair Mediated by RAD52 iScience, 3, 2018
|
|
3B27
| Hsp90 alpha N-terminal domain in complex with an inhibitor Ro4919127 | Descriptor: | 4-(2-chlorophenyl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, Heat shock protein HSP 90-alpha | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-07-21 | Release date: | 2011-09-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21, 2011
|
|
3B25
| Hsp90 alpha N-terminal domain in complex with an inhibitor CH4675194 | Descriptor: | 4-Methyl-6-(toluene-4-sulfonyl)-pyrimidin-2-ylamine, Heat shock protein HSP 90-alpha | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-07-21 | Release date: | 2011-09-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21, 2011
|
|
3WZE
| KDR in complex with ligand sorafenib | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ACETATE ION, ... | Authors: | Okamoto, K, Ikemori_Kawada, M, Inoue, A, Matsui, J. | Deposit date: | 2014-09-24 | Release date: | 2015-05-27 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization. ACS MED.CHEM.LETT., 6, 2015
|
|
5XP1
| |
2YZA
| Crystal structure of kinase domain of Human 5'-AMP-activated protein kinase alpha-2 subunit mutant (T172D) | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Authors: | Saijo, S, Takagi, T, Yoshikawa, S, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-04 | Release date: | 2008-05-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Structural basis for compound C inhibition of the human AMP-activated protein kinase alpha 2 subunit kinase domain Acta Crystallogr.,Sect.D, 67, 2011
|
|
5YY9
| Crystal structure of Tandem Tudor Domain of human UHRF1 in complex with LIG1-K126me3 | Descriptor: | E3 ubiquitin-protein ligase UHRF1, Ligase 1 | Authors: | Kori, S, Defossez, P.A, Arita, K. | Deposit date: | 2017-12-08 | Release date: | 2018-12-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.653 Å) | Cite: | Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Structure, 27, 2019
|
|
5YYA
| Crystal structure of Tandem Tudor Domain of human UHRF1 | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1, SULFATE ION | Authors: | Kori, S, Defossez, P.A, Arita, K. | Deposit date: | 2017-12-08 | Release date: | 2018-12-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Structure, 27, 2019
|
|
3ADE
| Crystal Structure of Keap1 in Complex with Sequestosome-1/p62 | Descriptor: | Kelch-like ECH-associated protein 1, SULFATE ION, Sequestosome-1 | Authors: | Kurokawa, H, Yamamoto, M. | Deposit date: | 2010-01-19 | Release date: | 2010-03-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Nat.Cell Biol., 12, 2010
|
|
3ALQ
| Crystal structure of TNF-TNFR2 complex | Descriptor: | COBALT (II) ION, Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1B | Authors: | Mukai, Y, Nakamura, T, Yamagata, Y, Tsutsumi, Y. | Deposit date: | 2010-08-06 | Release date: | 2010-11-17 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Solution of the Structure of the TNF-TNFR2 Complex Sci.Signal., 3, 2010
|
|
3VHD
| Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor, CH5164840 | Descriptor: | 4-amino-18,20-dimethyl-7-thia-3,5,11,15-tetraazatricyclo[15.3.1.1(2,6)]docosa-1(20),2,4,6(22),17(21),18-hexaene-10,16-dione, Heat shock protein HSP 90-alpha | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-08-24 | Release date: | 2012-07-18 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors Bioorg.Med.Chem.Lett., 22, 2012
|
|
3B26
| Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850 | Descriptor: | 4-(1H,3H-benzo[de]isochromen-6-yl)-6-methylpyrimidin-2-amine, Heat shock protein HSP 90-alpha | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-07-21 | Release date: | 2011-09-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21, 2011
|
|
2DW2
| Crystal structure of VAP2 from Crotalus atrox venom (Form 2-5 crystal) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)][2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Catrocollastatin, ... | Authors: | Takeda, S, Igarashi, T, Araki, S. | Deposit date: | 2006-08-02 | Release date: | 2007-07-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins Febs Lett., 581, 2007
|
|
2DW0
| Crystal structure of VAP2 from Crotalus atrox venom (Form 2-1 crystal) | Descriptor: | 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, CALCIUM ION, Catrocollastatin, ... | Authors: | Takeda, S, Igarashi, T, Araki, S. | Deposit date: | 2006-08-02 | Release date: | 2007-07-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins Febs Lett., 581, 2007
|
|
3B21
| |
3AQV
| Human AMP-activated protein kinase alpha 2 subunit kinase domain (T172D) complexed with compound C | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Authors: | Handa, N, Takagi, T, Saijo, S, Kishishita, S, Toyama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2010-11-19 | Release date: | 2011-04-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structural basis for compound C inhibition of the human AMP-activated protein kinase alpha 2 subunit kinase domain Acta Crystallogr.,Sect.D, 67, 2011
|
|
2DW1
| Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal) | Descriptor: | 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, CALCIUM ION, Catrocollastatin, ... | Authors: | Takeda, S, Igarashi, T, Araki, S. | Deposit date: | 2006-08-02 | Release date: | 2007-07-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins Febs Lett., 581, 2007
|
|
2ZVU
| Crystal structure of rat heme oxygenase-1 in complex with ferrous verdoheme | Descriptor: | 5-OXA-PROTOPORPHYRIN IX CONTAINING FE, FORMIC ACID, Heme oxygenase 1 | Authors: | Sato, H, Sugishima, M, Fukuyama, K, Noguchi, M. | Deposit date: | 2008-11-21 | Release date: | 2009-02-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of rat haem oxygenase-1 in complex with ferrous verdohaem: presence of a hydrogen-bond network on the distal side Biochem.J., 419, 2009
|
|
7VX6
| OXA-58 crystal structure of acylated meropenem complex 2 | Descriptor: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, ... | Authors: | Saino, H, Sugiyabu, T, Miyano, M. | Deposit date: | 2021-11-12 | Release date: | 2022-11-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | OXA-58 crystal structure of acylated meropenem complex 2 To be published
|
|
1UGN
| Crystal structure of LIR1.02, one of the alleles of LIR1 | Descriptor: | Leukocyte immunoglobulin-like receptor 1 | Authors: | Shiroishi, M, Rasubala, L, Kuroki, K, Amano, K, Tsuchiya, N, Tokunaga, K, Kohda, D, Maenaka, K. | Deposit date: | 2003-06-17 | Release date: | 2004-08-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. Hum.Mol.Genet., 14, 2005
|
|
2DX8
| |
7VX3
| OXA-58 crystal structure of acylated meropenem complex 2 | Descriptor: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, ... | Authors: | Saino, H, Sugiyabu, T, Miyano, M. | Deposit date: | 2021-11-12 | Release date: | 2022-11-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | OXA-58 crystal structure of acylated meropenem complex 2 To be published
|
|
3AW5
| Structure of a multicopper oxidase from the hyperthermophilic archaeon Pyrobaculum aerophilum | Descriptor: | ACETATE ION, COPPER (II) ION, CU-O-CU LINKAGE, ... | Authors: | Sakuraba, H, Ohshima, T, Yoneda, K. | Deposit date: | 2011-03-10 | Release date: | 2011-06-08 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of a multicopper oxidase from the hyperthermophilic archaeon Pyrobaculum aerophilum Acta Crystallogr.,Sect.F, 67, 2011
|
|
5YXM
| Crystal structure of Chlamydomonas Outer Arm Dynein Light Chain 1 | Descriptor: | Dynein light chain 1, axonemal, PHOSPHATE ION | Authors: | Toda, A, Tanaka, H, Nishikawa, Y, Yagi, T, Kurisu, G. | Deposit date: | 2017-12-06 | Release date: | 2018-03-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.545 Å) | Cite: | Structural atlas of dynein motors at atomic resolution. Biophys Rev, 10, 2018
|
|
2CXF
| RUN domain of Rap2 interacting protein x, crystallized in C2 space group | Descriptor: | rap2 interacting protein x | Authors: | Kukimoto-Niino, M, Murayama, K, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-06-29 | Release date: | 2005-12-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | Crystal Structure of the RUN Domain of the RAP2-interacting Protein x J.Biol.Chem., 281, 2006
|
|