2YZA

Crystal structure of kinase domain of Human 5'-AMP-activated protein kinase alpha-2 subunit mutant (T172D)

Summary for 2YZA

• Entry DOI: 10.2210/pdb2yza/pdb
• Related: 2H6D
• Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-2 (2 entities in total)
• Functional Keywords: signaling protein, serine/threonine protein kinase, phosphorylation, atp-binding, nucleotide-binding, cholesterol biosynthesis, fatty acid biosynthesis, lipid synthesis, glucose metabolism, magnesium, metal-binding, serine/threonine-protein kinase, steroid biosynthesis, transferase, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): P54646
• Total number of polymer chains: 1
• Total formula weight: 31571.73

Authors

Saijo, S.,Takagi, T.,Yoshikawa, S.,Kishishita, S.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-05-04, release date: 2008-05-06, Last modification date: 2023-10-25)

• Primary citation: Handa, N.,Takagi, T.,Saijo, S.,Kishishita, S.,Takaya, D.,Toyama, M.,Terada, T.,Shirouzu, M.,Suzuki, A.,Lee, S.,Yamauchi, T.,Okada-Iwabu, M.,Iwabu, M.,Kadowaki, T.,Minokoshi, Y.,Yokoyama, S.; Structural basis for compound C inhibition of the human AMP-activated protein kinase alpha 2 subunit kinase domain; Acta Crystallogr.,Sect.D, 67:480-487, 2011; PubMed: 21543851; DOI: 10.1107/S0907444911010201

Experimental method

X-RAY DIFFRACTION (3.02 Å)