3AQV

Human AMP-activated protein kinase alpha 2 subunit kinase domain (T172D) complexed with compound C

Summary for 3AQV

Related2yza 2h6d
Descriptor5'-AMP-activated protein kinase catalytic subunit alpha-2, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine (3 entities in total)
Functional Keywordsstructural genomics, riken structural genomics/proteomics initiative, rsgi, transferase, signaling protein, serine/threonine protein kinase, phosphorylation, atp-binding, nucleotide-binding, cholesterol biosynthesis, fatty acid biosynthesis, lipid synthesis, glucose metabolism, magnesium, metal-binding, serine/threonine-protein kinase, steroid biosynthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity) P54646
Total number of polymer chains1
Total molecular weight31971.22
Authors
Handa, N.,Takagi, T.,Saijo, S.,Kishishita, S.,Toyama, M.,Terada, T.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2010-11-19, release date: 2011-04-27, Last modification date: 2012-04-11)
Primary citation
Handa, N.,Takagi, T.,Saijo, S.,Kishishita, S.,Takaya, D.,Toyama, M.,Terada, T.,Shirouzu, M.,Suzuki, A.,Lee, S.,Yamauchi, T.,Okada-Iwabu, M.,Iwabu, M.,Kadowaki, T.,Minokoshi, Y.,Yokoyama, S.
Structural basis for compound C inhibition of the human AMP-activated protein kinase alpha 2 subunit kinase domain
Acta Crystallogr.,Sect.D, 67:480-487, 2011
PubMed: 21543851 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444911010201
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.08 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26833 1.5% 6.8% 15.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
170172
PDB entries from 2020-10-21