3AQV
Human AMP-activated protein kinase alpha 2 subunit kinase domain (T172D) complexed with compound C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | polymer | 276 | 31571.7 | 1 | UniProt (P54646) Pfam (PF00069) | Homo sapiens (human) | AMPK subunit alpha-2 |
| 2 | B (A) | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | non-polymer | 399.5 | 1 | Chemie (TAK) | |||
| 3 | C (A) | water | water | 18.0 | 112 | Chemie (HOH) |
Sequence modifications
A: 6 - 279 (UniProt: P54646)
| PDB | External Database | Details |
|---|---|---|
| Gly 4 | - | expression tag |
| Ser 5 | - | expression tag |
| Asp 172 | Thr 172 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31571.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 399.5 | |
| All* | Total formula weight | 31971.2 |
