3AQV

Human AMP-activated protein kinase alpha 2 subunit kinase domain (T172D) complexed with compound C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TAK A 1

Chain	Residue
A	ALA43
A	LEU146
A	MET164
A	HOH298
A	LYS45
A	GLU94
A	TYR95
A	VAL96
A	SER97
A	GLY98
A	GLY99
A	ASP103

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGVGTFGKVKiGehqltghk..........VAVK

Chain	Residue	Details
A	LEU22-LYS45

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpeNVLL

Chain	Residue	Details
A	VAL135-LEU147

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP139

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LYS45
A	LEU22

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by LKB1 and CaMKK2 => ECO:0000269|PubMed:15980064, ECO:0000269|PubMed:24767988, ECO:0000269|PubMed:28552616

Chain	Residue	Details
A	ASP172

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q09137

Chain	Residue	Details
A	THR258

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