8K9Q
 
 | | Cryo-EM structure of the GPI inositol-deacylase (PGAP1/Bst1) from Chaetomium thermophilum | | Descriptor: | (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid, CHOLESTEROL HEMISUCCINATE, GPI inositol-deacylase,fused thermostable green fluorescent protein | | Authors: | Hong, J, Li, T, Qu, Q, Li, D. | | Deposit date: | 2023-08-01 | | Release date: | 2023-12-20 | | Last modified: | 2025-07-16 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis.
Nat Commun, 15, 2024
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8K9T
 | | Cryo-EM structure of the products-bound PGAP1(Bst1)-S327A from Chaetonium thermophilum | | Descriptor: | 2-amino-2-deoxy-alpha-D-glucopyranose, 2-azanylethyl [(2R,3S,4S,5S,6S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hydrogen phosphate, 2-azanylethyl [(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphate, ... | | Authors: | Li, T, Hong, J, Qu, Q, Li, D. | | Deposit date: | 2023-08-01 | | Release date: | 2023-12-20 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis.
Nat Commun, 15, 2024
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8K9R
 | | Cryo EM structure of the products-bound PGAP1(Bst1)-H443N from Chaetomium thermophilum | | Descriptor: | 2-amino-2-deoxy-alpha-D-glucopyranose, 2-azanylethyl [(2R,3S,4S,5S,6S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hydrogen phosphate, 2-azanylethyl [(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphate, ... | | Authors: | Li, T, Hong, J, Qu, Q, Li, D. | | Deposit date: | 2023-08-01 | | Release date: | 2023-12-20 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis.
Nat Commun, 15, 2024
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7DE1
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8VHG
 | | Structure of the BMAL1/HIF2A heterodimer in Complex with DNA | | Descriptor: | Basic helix-loop-helix ARNT-like protein 1, Endothelial PAS domain-containing protein 1, Forward strand DNA containing HRE motif, ... | | Authors: | Li, T, Tsai, K.L. | | Deposit date: | 2024-01-01 | | Release date: | 2025-02-12 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury.
Nature, 641, 2025
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8XAJ
 | | Cryo-EM structure of OSCA1.2-liposome-inside-in open state | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Calcium permeable stress-gated cation channel 1 | | Authors: | Zhang, Y, Han, Y. | | Deposit date: | 2023-12-04 | | Release date: | 2024-04-10 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
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5WQ4
 | | Crystal structure of OPTN and linear diubiquitin complex | | Descriptor: | Optineurin, ubiquitin | | Authors: | Li, F, Pan, L. | | Deposit date: | 2016-11-23 | | Release date: | 2017-12-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation.
Autophagy, 14, 2018
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5X0W
 | | Molecular mechanism for the binding between Sharpin and HOIP | | Descriptor: | E3 ubiquitin-protein ligase RNF31, Sharpin | | Authors: | Liu, J, Li, F, Cheng, X, Pan, L. | | Deposit date: | 2017-01-23 | | Release date: | 2017-10-18 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Insights into SHARPIN-Mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly
Cell Rep, 21, 2017
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6K07
 | | Crystal structure of REV7(R124A) in complex with a Shieldin3 fragment | | Descriptor: | Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3 | | Authors: | Zhang, F, Dai, Y. | | Deposit date: | 2019-05-05 | | Release date: | 2019-12-11 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair.
J.Biol.Chem., 295, 2020
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6LBM
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6LBI
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6K08
 | | Crystal structure of REV7(R124A/A135D) in complex with a Shieldin3 fragment | | Descriptor: | Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3 | | Authors: | Zhang, F, Dai, Y. | | Deposit date: | 2019-05-05 | | Release date: | 2019-12-11 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.312 Å) | | Cite: | Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair.
J.Biol.Chem., 295, 2020
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8Z7X
 | | SLC19A3-Thiamine inward structure | | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z80
 | | SLC19A2-Pyridoxine inward structure | | Descriptor: | 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol, Thiamine transporter 1 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Last modified: | 2025-07-16 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7R
 | | SLC19A3 apo structure | | Descriptor: | Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Last modified: | 2025-07-16 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7T
 | | SLC19A3-Pyridoxine outward structure | | Descriptor: | 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Last modified: | 2025-07-16 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7S
 | | SLC19A3-thiamine outward structure | | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7W
 | | SLC19A3-Metformin outward structure | | Descriptor: | Metformin, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7V
 | | Slc19A3-Amprolium outward structure | | Descriptor: | Amprolium, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Last modified: | 2025-07-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7Y
 | | SLC19A3-Fedratinib inward structure | | Descriptor: | N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7U
 | | SLC19A3-Fedratinib outward structure | | Descriptor: | N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8Z7Z
 | | SLC19A2-Thiamine inward structure | | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Thiamine transporter 1 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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8YTX
 | | Tubulin-RB3-TTL in complex with compound SI9 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-~{N}-(4-methoxyphenyl)-~{N}-methyl-thieno[2,3-d]pyrimidin-4-amine, CALCIUM ION, ... | | Authors: | Wu, C.Y, Wang, Y.X. | | Deposit date: | 2024-03-26 | | Release date: | 2024-06-05 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Eur.J.Med.Chem., 276, 2024
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8YU9
 | | Tubulin-RB3-TTL in complex with compound SI10 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chloranylthieno[3,2-d]pyrimidin-4-yl)-7-methoxy-1,3-dihydroquinoxalin-2-one, CALCIUM ION, ... | | Authors: | Wu, C.Y, Wang, Y.X. | | Deposit date: | 2024-03-27 | | Release date: | 2024-06-05 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Eur.J.Med.Chem., 276, 2024
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8YUA
 | | Tubulin-RB3-TTL in complex with compound SI10 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-~{N}-(4-methoxyphenyl)-~{N}-methyl-thieno[3,2-d]pyrimidin-4-amine, CALCIUM ION, ... | | Authors: | Wu, C.Y, Wang, Y.X. | | Deposit date: | 2024-03-27 | | Release date: | 2024-06-05 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Eur.J.Med.Chem., 276, 2024
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