9QK2

Structure of the Complement classical and lectin pathway C3 convertase in complex with substrate C3

Summary for 9QK2

Entry DOI	10.2210/pdb9qk2/pdb
Related	9QJ4 9QJ5 9QPY
EMDB information	53217
Descriptor	Complement C4-A, Complement C2, Anti-C4b nanobody B12, ... (6 entities in total)
Functional Keywords	c3 convertase, complement classical pathway, convertase-substrate complex, c3 substrate, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	7
Total formula weight	1052218.26
Authors	De la O Becerra, K.I.,Brondijk, T.H.C.,Gros, P. (deposition date: 2025-03-19, release date: 2025-12-24)
Primary citation	De la O Becerra, K.I.,Brondijk, T.H.C.,Serna Martin, I.,Gros, P. Mechanistic insights into complement classical pathway C3 convertase based on cryo-EM structures To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation