9QK2

Structure of the Complement classical and lectin pathway C3 convertase in complex with substrate C3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, D (A, C, B)	Complement C4-A	polymer	1744	192993.2	3	UniProt (P0C0L4)	Homo sapiens (human)	Acidic complement C4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
2	C (E)	Complement C2	polymer	752	83347.8	1	UniProt (P06681)	Homo sapiens (human)	C3/C5 convertase
3	E (D)	Anti-C4b nanobody B12	polymer	120	13322.9	1		Lama glama
4	F, G (F, G)	Complement C3	polymer	1663	187387.0	2	UniProt (P01024)	Homo sapiens (human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
5	H, J, K, L, M... (A, E, B, F, G)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
6	I (E)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

A, C, B: 1 - 1744 (UniProt: P0C0L4)

PDB	External Database	Details
Ser 1201	Thr 1201	variant

E: 1 - 752 (UniProt: P06681)

PDB	External Database	Details
Ala 679	Ser 679	engineered mutation

F, G: 1 - 1663 (UniProt: P01024)

PDB	External Database	Details
Leu 314	Pro 314	variant

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	1050424.3
Non-Polymers*	Number of molecules	9
	Total formula weight	1794.0
All*	Total formula weight	1052218.3

*Water molecules are not included.